INT89784

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 8.39
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
spinal cord 4
intestine 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Analgesic 4 100.00 Very High Very High Very High
intrathecal 2 99.88 Very High Very High Very High
pulpitis 2 99.84 Very High Very High Very High
qutenza 11 99.50 Very High Very High Very High
Inflammation 109 99.20 Very High Very High Very High
agonist 49 98.36 Very High Very High Very High
Bile 2 97.00 Very High Very High Very High
COX-2 inhibitor 3 94.48 High High
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Sprains And Strains 60 99.88 Very High Very High Very High
Cirrhosis 8 99.84 Very High Very High Very High
Pulpitis 2 99.84 Very High Very High Very High
Colitis 5 99.38 Very High Very High Very High
Apoptosis 47 99.22 Very High Very High Very High
INFLAMMATION 125 99.20 Very High Very High Very High
Urological Neuroanatomy 5 99.04 Very High Very High Very High
Inflammatory Bowel Disease 7 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B can induce the expression of iNOS mRNA through NF-?
Regulation (through) of Transcription (expression) of iNOS
1) Confidence 0.42 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952320 Disease Relevance 1.07 Pain Relevance 0
Experimental evidences provide the existence of a threshold in the magnitude of DCS that regulates the mRNA expression of nitric oxide synthase (NOS2), an inducible pro-inflammatory enzyme.
Regulation (regulates) of Transcription (expression) of NOS2 associated with inflammation and sprains and strains
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2667254 Disease Relevance 1.10 Pain Relevance 0.26
In addition, the mRNA levels of tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) were evaluated.
Regulation (evaluated) of Transcription (levels) of iNOS associated with necrosis and cancer
3) Confidence 0.38 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.08
[Relative analysis of the mRNA expression between endothelin and inducible nitric oxide synthase in pulpitis].
Regulation (analysis) of Transcription (expression) of inducible nitric oxide synthase associated with pulpitis
4) Confidence 0.38 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 11776875 Disease Relevance 0.10 Pain Relevance 0.19
In addition, the mRNA levels of tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1) were evaluated.
Regulation (evaluated) of Transcription (levels) of inducible nitric oxide synthase associated with necrosis and cancer
5) Confidence 0.33 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.08
[Effects of dynorphin A1-17 on the activities, immunoreactivities and mRNA expression of cNOS and iNOS in rat spinal cord and their mechanisms].
Regulation (mechanisms) of Transcription (expression) of iNOS in spinal cord associated with dynorphin, analgesic and spinal cord
6) Confidence 0.33 Published 1997 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 10921077 Disease Relevance 0.43 Pain Relevance 0.68
[Effects of dynorphin A1-17 on the activities, immunoreactivities and mRNA expression of cNOS and iNOS in rat spinal cord and their mechanisms].
Regulation ([Effects) of Transcription (expression) of iNOS in spinal cord associated with dynorphin, analgesic and spinal cord
7) Confidence 0.33 Published 1997 Journal Sheng Li Ke Xue Jin Zhan Section Title Doc Link 10921077 Disease Relevance 0.42 Pain Relevance 0.68
RESULTS: Statistical analysis (REST 2005) revealed a significant, 11-fold up-regulation (P=0.026) of the nNOS transcript but no significant changes in iNOS transcription.
Neg (no) Regulation (changes) of Transcription (transcription) of iNOS
8) Confidence 0.33 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0
To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.
Spec (analyzed) Regulation (consequences) of Transcription (levels) of iNOS associated with apoptosis
9) Confidence 0.33 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473255 Disease Relevance 0.57 Pain Relevance 0.13
The aim of the present study was: 1) to examine the expression of ghrelin and TNF-alpha mRNA in the inflamed colonic mucosa of patients with ulcerative colitis (UC), 2) to analyze the effect of treatment with exogenous ghrelin on the healing of trinitrobenze sulphonic acid (TNBS)-induced colitis in rats, and 3) to assess the effects of ghrelin treatment on mRNA expression for iNOS and protein expression for COX-2 and PPARalpha in intact colonic mucosa and in that with TNBS-induced colitis.
Regulation (effects) of Transcription (expression) of iNOS associated with colitis and inflammatory bowel disease
10) Confidence 0.32 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.92 Pain Relevance 0.19
Capsaicin treatment significantly modified gastric eNOS/iNOS/COX-2 mRNA expression in cirrhotic rats.
Regulation (modified) of Transcription (expression) of iNOS associated with cirrhosis and qutenza
11) Confidence 0.26 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18555214 Disease Relevance 0.78 Pain Relevance 0.77
Indomethacin decreased mucosal prostaglandin (PG)E2 content and caused damage in the intestine within 24 h, accompanied by an increase in intestinal contractility, bacterial numbers, and MPO as well as iNOS activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of Transcription (expression) of iNOS in intestine associated with urological neuroanatomy
12) Confidence 0.24 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438549 Disease Relevance 0.56 Pain Relevance 0.33
The development of intestinal lesions induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of Transcription (expression) of iNOS associated with urological neuroanatomy
13) Confidence 0.24 Published 2010 Journal Clin. Chim. Acta Section Abstract Doc Link 20074562 Disease Relevance 0.39 Pain Relevance 0.29
The iNOS-mRNA expression 3-18 h following stimulation and subsequent irradiation was not affected by doses < or = 1.25 Gy.
Neg (not) Regulation (affected) of Transcription (expression) of iNOS
14) Confidence 0.20 Published 2003 Journal Strahlenther Onkol Section Body Doc Link 12627258 Disease Relevance 0.06 Pain Relevance 0
regulates the activity of iNOS and activation of this PPAR
Regulation (regulates) of Transcription (activity) of iNOS
15) Confidence 0.05 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.96 Pain Relevance 0.56

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