INT89805

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 45
Total Number 48
Disease Relevance 11.03
Pain Relevance 20.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
hippocampus 8
neurons 5
SON 3
brain 2
neuronal 2
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 101 100.00 Very High Very High Very High
substance P 76 100.00 Very High Very High Very High
nav1.8 65 100.00 Very High Very High Very High
Hyperalgesia 40 100.00 Very High Very High Very High
pregabalin 400 99.98 Very High Very High Very High
nociceptor 8 99.92 Very High Very High Very High
Dorsal column 124 99.84 Very High Very High Very High
Hippocampus 57 99.84 Very High Very High Very High
Gabapentin 202 99.68 Very High Very High Very High
Spinal cord 103 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 43 100.00 Very High Very High Very High
Hydrocephalus 22 100.00 Very High Very High Very High
Stress 20 99.92 Very High Very High Very High
Death 73 99.72 Very High Very High Very High
Apoptosis 161 99.42 Very High Very High Very High
Convulsion 378 99.04 Very High Very High Very High
Epilepsy 116 98.94 Very High Very High Very High
Injury 19 97.76 Very High Very High Very High
Urological Neuroanatomy 4 97.76 Very High Very High Very High
Nociception 165 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To observe the accumulative analgesic effect of electroacupuncture (EA) and the simultaneous changes of protein kinase A (PKA) expression in hypothalamus and hippocampus in rats with chronic constrictive injury (CCI) or/and learning-memory impairment.
Gene_expression (expression) of PKA in hippocampus associated with cognitive disorder, analgesic, injury, hippocampus and electroacupuncture
1) Confidence 0.77 Published 2008 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 18630581 Disease Relevance 0.27 Pain Relevance 0.42
The different distribution and expression of PKA and P-CREB in the hippocampus of rats in different groups were investigated with immunohistochemistry and Westernblot technique.
Spec (investigated) Gene_expression (expression) of PKA in hippocampus
2) Confidence 0.70 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062949 Disease Relevance 0 Pain Relevance 0
The PKA and P-CREB protein expression levels in the hippocampus of model rats were significantly lower than those of the normal controls (P<0.05).
Gene_expression (expression) of PKA in hippocampus
3) Confidence 0.70 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062949 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To observe the effect of chronic unpredicted sequence of mild stress on the expression of cAMP-dependent protein kinase A(PKA) and phosphorylated cAMP-responsive element binding protein (P-CREB) in hippocampus of rats and the antagonism of antidepressors (fluoxetine).
Gene_expression (expression) of PKA in hippocampus associated with stress, hippocampus and fluoxetine
4) Confidence 0.70 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 17062949 Disease Relevance 0.17 Pain Relevance 0.18
[Effect of chronic stress on PKA and P-CREB expression in hippocampus of rats and the antagonism of antidepressors].
Gene_expression (expression) of PKA in hippocampus associated with stress and hippocampus
5) Confidence 0.70 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 17062949 Disease Relevance 0.19 Pain Relevance 0.18
CONCLUSION: Chronic unpredicted mild stress can affect the PKA and P-CREB expression in hippocampus of rats and fluoxetine has antagonism against it.


Gene_expression (expression) of PKA in hippocampus
6) Confidence 0.70 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062949 Disease Relevance 0 Pain Relevance 0
IGV of PKA, ARC and SON in OVX + CCI + EA 2 w group were markedly higher than those in CCI + EA 2 w group (P<0.05), suggesting an apparent attenuation of the cumulative upregulation effect of PKA expression after learning-memory injury.
Gene_expression (expression) of PKA in SON
7) Confidence 0.60 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
The changing tendency of PKA expression in hippocampal CA1 region was similar to that of SON after repeated EA of ST36 and GB34.
Gene_expression (expression) of PKA in SON
8) Confidence 0.60 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Repeated EA has a cumulative analgesic effect in CCI rats, which is probably related to its resultant upregulation of PKA expression in neurons of hypothalamus and hippocampus and the animals' neuro-memory.


Gene_expression (expression) of PKA in hippocampus
9) Confidence 0.60 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
IGV of PVN and SON in OVX + CCI + EA 2 w group were also markedly lower than those in OVX + CCI group (P<0.05), displaying upregulation and cumulative increase of PKA expression by EA 2 w.
Gene_expression (expression) of PKA in SON
10) Confidence 0.60 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 18630581 Disease Relevance 0 Pain Relevance 0
The PKA and P-CREB protein expression levels in the hippocampus of the fluoxetine group were significantly higher than those of the model group (P<0.05).
Gene_expression (expression) of PKA in hippocampus
11) Confidence 0.54 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 17062949 Disease Relevance 0 Pain Relevance 0
When the selective PKA inhibitor HA-1004 was infused, concomitantly with morphine pellets, it diminished the increase in NA turnover and the total TH levels observed in morphine-withdrawn rats.
Gene_expression (infused) of PKA associated with noradrenaline and morphine
12) Confidence 0.44 Published 2007 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 17216288 Disease Relevance 0.15 Pain Relevance 1.55
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Gene_expression (expression) of PKA in brain associated with convulsion
13) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.70 Pain Relevance 0.03
This study for the first time indicate that PTZ-induced seizures triggered activation of caspases-3 to induce widespread apoptotic neuronal death and decreased GABAB1R expression in hippocampal neurons, providing a possible mechanistic link between maternal epilepsy induced neurodegeneration alteration of GABAB1R and PKA expression level during prenatal brain development.
Gene_expression (expression) of PKA in neuronal associated with epilepsy, convulsion, apoptosis and death
14) Confidence 0.37 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 0.80 Pain Relevance 0.15
The RT-PCR and Western blot results showed significant increased expression of cytochrome-c and caspases-3, while decreased levels of GABAB1R, and PKA protein expression upon ethanol, PTZ and ethanol plus PTZ exposure in primary neuronal cells cultured from PTZ-induced seizure model as compare to non-PTZ treated maternal group.
Gene_expression (expression) of PKA in neuronal associated with convulsion
15) Confidence 0.37 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2706809 Disease Relevance 1.18 Pain Relevance 0.29
Our findings indicate that primary culture from PTZ-induced seizure model triggers robust caspase-3 activation, release of cytochrome-c and decrease GABAB1R expression which has further decreasing effect on PKA expression level in hippocampal neurons of prenatal rat brain, while the co treatment of baclofen and phaclofen reverse the effects of PTZ and provide neuroprotection.
Gene_expression (expression) of PKA in brain associated with convulsion
16) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.70 Pain Relevance 0.03
Immunoreactions were carried out using a rabbit polyclonal IgG GABAB1R (Santa Cruz),) or rabbit-derived anti-rat GABAB1R antibody (Abcam Limited, UK), PKA-?
Gene_expression (antibody) of PKA
17) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0 Pain Relevance 0.03
In present study, we have observed the effects of PTZ-induced seizure model on apoptotic neuronal death, GABAB1R and PKA expressional changes in prenatal rat hippocampal neurons.
Gene_expression (expressional) of PKA in neurons associated with convulsion, apoptosis and death
18) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2706809 Disease Relevance 0.59 Pain Relevance 0
Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expression and intracellular signal transduction elements [protein kinase A regulatory subunit II (PKA) and phosphorylated cAMP response element binding protein (pCREB)] in brainstem noradrenergic nuclei.
Gene_expression (expression) of PKA in brainstem associated with medulla and withdrawal
19) Confidence 0.29 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.56
In this study, to determine whether similar cellular changes occurred in forebrain nuclei associated with drug reward, expressions of PKA and pCREB were analyzed in the ventral tegmental area, frontal cortex, striatum, and amygdala of opiate-treated rats that received low doses of naltrexone in their drinking water.
Spec (analyzed) Gene_expression (expressions) of PKA in ventral associated with ventral tegmentum, urological neuroanatomy, opiate and amygdala
20) Confidence 0.29 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.10 Pain Relevance 0.68

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