INT89824

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.69
Pain Relevance 1.66

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cytosol (HSD17B1) small molecule metabolic process (HSD17B1) oxidoreductase activity (HSD17B1)
cytoplasm (HSD17B1)
Anatomy Link Frequency
hippocampus 2
temporal lobe 1
HSD17B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 32 98.68 Very High Very High Very High
cytokine 6 91.12 High High
depression 4 89.56 High High
Migraine 4 89.08 High High
Neuronal excitability 4 84.84 Quite High
agonist 2 62.88 Quite High
Clonidine 2 54.24 Quite High
Disease Link Frequency Relevance Heat
Convulsion 4 99.70 Very High Very High Very High
Epilepsy 20 99.30 Very High Very High Very High
Obesity 8 93.36 High High
Sclerosis 4 91.56 High High
Anxiety Disorder 4 90.04 High High
Depression 4 89.56 High High
Headache 4 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of 17beta-HSD isozymes has not yet been studied in human hippocampus.
Gene_expression (expression) of 17beta-HSD in hippocampus associated with hippocampus
1) Confidence 0.75 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.35
Therefore, we investigated the expression of 17beta-HSD 1, 2, 3 and 4 mRNAs in hippocampal tissue specimens obtained at neurosurgery from 42 patients with pharmacoresistant temporal lobe epilepsy.
Gene_expression (expression) of 17beta-HSD 1 in temporal lobe associated with epilepsy
2) Confidence 0.65 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.37
No significant correlation could be detected between duration of epilepsy, individual seizure frequency and expression levels of 17beta-HSDs.
Gene_expression (expression) of 17beta-HSD associated with epilepsy and convulsion
3) Confidence 0.65 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.52 Pain Relevance 0.30
A competitive RT-PCR assay was used to quantify the mRNA transcript level. 17beta-HSD 1 mRNA concentrations were 10000 fold lower in the hippocampus compared to placental tissue, whereas 17beta-HSD 3 mRNA concentrations were 50 fold lower than in testis and 17beta-HSD 4 concentrations were in the same order of magnitude as in liver. 17beta-HSD 2 mRNA was not expressed. 17beta-HSD 1, 3 and 4 mRNA concentrations in the hippocampus showed no significant differences between men and women and there were no significant differences in expression levels of these enzymes between patients with Ammon's horn sclerosis (AHS) and those with histopathologically normal hippocampus associated with extrahippocampal lesions.
Gene_expression (expressed) of 17beta-HSD in Ammon's horn associated with sclerosis and hippocampus
4) Confidence 0.65 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.70 Pain Relevance 0.41
Neither CRH nor ACTH affected 11 beta-HSD-1 mRNA expression.
Gene_expression (expression) of beta-HSD-1
5) Confidence 0.50 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.21 Pain Relevance 0.17
Expression of 11 beta-HSD-1 mRNA was determined by real-time PCR, whereas lipolytic effects were determined by measuring glycerol concentration in the culture medium.
Gene_expression (Expression) of beta-HSD-1
6) Confidence 0.50 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.24 Pain Relevance 0.07

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