INT89825

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.33
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP11A1) small molecule metabolic process (CYP11A1)
Anatomy Link Frequency
lateral 3
brain 1
hippocampus 1
CYP11A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 8 99.44 Very High Very High Very High
Pain 117 99.14 Very High Very High Very High
corticosteroid 27 86.40 High High
Serotonin 1 77.28 Quite High
Dismenorea 1 53.36 Quite High
depression 2 50.56 Quite High
Pain score 9 34.84 Quite Low
Migraine 1 34.72 Quite Low
Neuronal excitability 1 30.48 Quite Low
Acupuncture 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 108 99.14 Very High Very High Very High
Epilepsy 6 95.80 Very High Very High Very High
Convulsion 1 89.12 High High
Sclerosis 1 81.28 Quite High
Fatigue 1 55.44 Quite High
Disease 9 54.24 Quite High
Reprotox - General 1 1 53.36 Quite High
Post-partum Depression 1 51.52 Quite High
Depressive Disorder 1 47.92 Quite Low
Dementia 1 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain.
Gene_expression (presence) of P450SCC in brain
1) Confidence 0.75 Published 2001 Journal Eur. J. Endocrinol. Section Abstract Doc Link 11720889 Disease Relevance 0.16 Pain Relevance 0.12
Together with data on 5alpha-reductase 1, 3alpha-hydroxisteroid oxidoreductase 2 and cytochrome P450scc, previously shown to be expressed in the human hippocampus also, our data provide further evidence for the existence of sex steroid formation and metabolism in this specific brain area.
Gene_expression (expressed) of cytochrome P450scc in hippocampus associated with hippocampus
2) Confidence 0.55 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.49 Pain Relevance 0.25
Seven of these patients had bi-lateral heel pain and it was possible for these patients to receive both steroid and placebo injection, or 2 steroid injections, or 2 placebo injections.
Gene_expression (injections) of steroid in lateral associated with pain
3) Confidence 0.04 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1112594 Disease Relevance 0.56 Pain Relevance 0.55
Seven of these patients had bi-lateral heel pain and it was possible for these patients to receive both steroid and placebo injection, or 2 steroid injections, or 2 placebo injections.
Gene_expression (receive) of steroid in lateral associated with pain
4) Confidence 0.04 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1112594 Disease Relevance 0.55 Pain Relevance 0.54
Seven of these patients had bi-lateral heel pain and it was possible for these patients to receive both steroid and placebo injection, or 2 steroid injections, or 2 placebo injections.
Gene_expression (injections) of steroid in lateral associated with pain
5) Confidence 0.04 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1112594 Disease Relevance 0.57 Pain Relevance 0.55

General Comments

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