INT89826

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.75
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HSD17B1) small molecule metabolic process (HSD17B1) oxidoreductase activity (HSD17B1)
cytoplasm (HSD17B1)
Anatomy Link Frequency
temporal lobe 2
hippocampus 2
HSD17B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 99.72 Very High Very High Very High
Hippocampus 32 98.68 Very High Very High Very High
depression 4 85.08 High High
Migraine 4 84.60 Quite High
Neuronal excitability 4 80.36 Quite High
agonist 3 75.28 Quite High
Clonidine 3 66.64 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 20 99.32 Very High Very High Very High
Convulsion 4 95.40 Very High Very High Very High
Obesity 12 93.36 High High
Sclerosis 4 87.56 High High
Anxiety Disorder 4 85.56 High High
Depression 4 85.08 High High
Headache 4 84.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the present study is the first to demonstrate mRNA expression of 17beta-HSD 1, 3 and 4 in the epileptic human hippocampus.
Transcription (expression) of 17beta-HSD in hippocampus associated with epilepsy and hippocampus
1) Confidence 0.69 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.28
Therefore, we investigated the expression of 17beta-HSD 1, 2, 3 and 4 mRNAs in hippocampal tissue specimens obtained at neurosurgery from 42 patients with pharmacoresistant temporal lobe epilepsy.
Transcription (expression) of 17beta-HSD 1 in temporal lobe associated with epilepsy
2) Confidence 0.52 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.37
Therefore, we investigated the expression of 17beta-HSD 1, 2, 3 and 4 mRNAs in hippocampal tissue specimens obtained at neurosurgery from 42 patients with pharmacoresistant temporal lobe epilepsy.
Transcription (expression) of 17beta-HSD in temporal lobe associated with epilepsy
3) Confidence 0.52 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.37
In conclusion, the present study is the first to demonstrate mRNA expression of 17beta-HSD 1, 3 and 4 in the epileptic human hippocampus.
Transcription (expression) of 17beta-HSD 1 in hippocampus associated with epilepsy and hippocampus
4) Confidence 0.52 Published 2000 Journal Epilepsy Res. Section Abstract Doc Link 10924871 Disease Relevance 0.51 Pain Relevance 0.28
Expression of 11 beta-HSD-1 mRNA was determined by real-time PCR, whereas lipolytic effects were determined by measuring glycerol concentration in the culture medium.
Transcription (Expression) of beta-HSD-1
5) Confidence 0.40 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.24 Pain Relevance 0.07
Neither CRH nor ACTH affected 11 beta-HSD-1 mRNA expression.
Transcription (expression) of beta-HSD-1
6) Confidence 0.40 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.21 Pain Relevance 0.17
TNF alpha up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10(-9) M (140 +/- 20%; P < 0.001); the same cytokine increased 11 beta-HSD-1 mRNA levels to 3-fold of control (P < 0.05) and increased medium glycerol levels to 165 +/- 14% of control (P < 0.01).
Transcription (levels) of beta-HSD-1 associated with cytokine
7) Confidence 0.40 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.25 Pain Relevance 0.19

General Comments

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