INT89830

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
dendrites 1
spinal cord 1
nerve 1
Gphn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 7 100.00 Very High Very High Very High
intrathecal 4 99.42 Very High Very High Very High
Spinal cord 8 98.88 Very High Very High Very High
agonist 5 97.84 Very High Very High Very High
Pain 6 96.08 Very High Very High Very High
Hyperalgesia 1 94.92 High High
Sciatic nerve 3 93.72 High High
Morphine 9 93.20 High High
tolerance 2 92.48 High High
spinal dorsal horn 1 89.56 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 99.54 Very High Very High Very High
Hyperalgesia 1 94.92 High High
Vibrio Infection 1 90.40 High High
Cancer 2 77.88 Quite High
Pain 4 77.44 Quite High
Morphine Dependence 2 75.00 Quite High
Drug Dependence 2 74.52 Quite High
Nociception 1 65.64 Quite High
INFLAMMATION 1 65.16 Quite High
Cancer Pain 1 44.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine receptor-associated protein gephyrin on their cell bodies and proximal dendrites.
Positive_regulation (levels) of gephyrin in dendrites
1) Confidence 0.45 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226680 Disease Relevance 0.09 Pain Relevance 0.26
Under these conditions, the nerve injury induced a significant increase in protein level of protein kinase Cgamma isoform in plasma membranes in the spinal cord.
Positive_regulation (increase) of isoform in nerve associated with nervous system injury and spinal cord
2) Confidence 0.00 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10924925 Disease Relevance 0.29 Pain Relevance 0.47
We recently found that repeated administration of mu-agonist causes a down regulation of mu-receptor-mediated G-protein activation, which is associated with a specific upregulation of PKC gamma isoform.
Positive_regulation (upregulation) of isoform associated with kinase c and agonist
3) Confidence 0.00 Published 2000 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 11144149 Disease Relevance 0.44 Pain Relevance 1.32
These findings indicate that repeated intrathecal administration of DAMGO may activate the PKCgamma isoform and in turn cause a desensitization of mu-receptor-mediated G-protein activation in the mouse spinal cord.
Spec (may) Positive_regulation (activate) of isoform in spinal cord associated with spinal cord and intrathecal
4) Confidence 0.00 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.57

General Comments

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