INT89834

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.89
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN2A)
Anatomy Link Frequency
plasma 1
SCN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.1 8 100.00 Very High Very High Very High
Nav1.2 6 100.00 Very High Very High Very High
sodium channel 15 99.96 Very High Very High Very High
tetrodotoxin 13 99.44 Very High Very High Very High
nav1.3 7 98.16 Very High Very High Very High
lidocaine 1 96.00 Very High Very High Very High
Nav1.6 7 95.76 Very High Very High Very High
Nav1.7 7 94.40 High High
Nerve growth factor 1 92.28 High High
Root ganglion neuron 2 92.12 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 15 99.60 Very High Very High Very High
Cognitive Disorder 2 98.48 Very High Very High Very High
Repression 1 97.92 Very High Very High Very High
Hyperglycemia 2 95.20 Very High Very High Very High
Disease 1 94.72 High High
Epilepsy 2 93.88 High High
Febrile Convulsions 1 92.64 High High
Convulsion 1 91.92 High High
Ganglion Cysts 2 91.80 High High
Pain 5 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of REST, the CoREST/HDAC2 complex occupied the native Nav1.2 sodium channel gene in chromatin.
Positive_regulation (occupied) of Nav1.2 associated with sodium channel and nav1.2
1) Confidence 0.49 Published 2001 Journal Neuron Section Abstract Doc Link 11516394 Disease Relevance 0.10 Pain Relevance 0.24
Both Na(V)1.2 and Na(V)1.6 were strongly blocked; within experimental wash times of 40-60 min, block was reversed very little for Na(V)1.2 and only partially for Na(V)1.6.
Neg (little) Spec (partially) Positive_regulation (little) of Na(V)1.2
2) Confidence 0.49 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17724025 Disease Relevance 0.26 Pain Relevance 1.07
subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).
Positive_regulation (include) of SCN2A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6
3) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.27
"Cognitive functioning" was the only HRQoL scale on which diabetic subjects with high levels of HbA(1c) (HbA(1c)>7.0%) scored worse than those with acceptable levels (HbA(1c)<7.0%).
Positive_regulation (levels) of HbA associated with cognitive disorder and diabetes mellitus
4) Confidence 0.45 Published 2000 Journal J. Diabetes Complicat. Section Abstract Doc Link 10925063 Disease Relevance 0.89 Pain Relevance 0.09
METHODS AND RESULTS: We compared HbA(1c) (percentage) and the time to onset of a > or =1% increase in HbA(1c) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial.
Positive_regulation (increase) of HbA
5) Confidence 0.45 Published 2009 Journal Circulation Section Body Doc Link 19349325 Disease Relevance 0.10 Pain Relevance 0
METHODS AND RESULTS: We compared HbA(1c) (percentage) and the time to onset of a > or =1% increase in HbA(1c) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial.
Positive_regulation (increase) of HbA
6) Confidence 0.45 Published 2009 Journal Circulation Section Body Doc Link 19349325 Disease Relevance 0.09 Pain Relevance 0
We screened SCN2A for mutations and carried out in vitro electrophysiologic analyses to study the consequences of the identified mutation.
Positive_regulation (screened) of SCN2A
7) Confidence 0.40 Published 2010 Journal Neurology Section Body Doc Link 20956790 Disease Relevance 0.28 Pain Relevance 0
OGTT was often elevated, whereas both fasting plasma glucose and HbA(1c) were normal.
Positive_regulation (elevated) of HbA in plasma
8) Confidence 0.20 Published 2001 Journal Diabetes Care Section Body Doc Link 11473085 Disease Relevance 0.17 Pain Relevance 0
At the end of a ramp to -20 mV, a sudden repolarization to approximately -35 mV fully deactivated I(Na2).
Positive_regulation (deactivated) of Na2
9) Confidence 0.05 Published 2008 Journal Exp. Physiol. Section Abstract Doc Link 17993508 Disease Relevance 0 Pain Relevance 0.10

General Comments

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