INT89844

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 4.71
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
urethra 5
spinal cord 4
external 3
neurons 2
epithelial cell 2
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Delta opioid receptors 1 100.00 Very High Very High Very High
Spinal cord 124 99.92 Very High Very High Very High
MU agonist 1 99.72 Very High Very High Very High
Hippocampus 32 99.68 Very High Very High Very High
intrathecal 71 99.48 Very High Very High Very High
Dorsal horn 48 98.24 Very High Very High Very High
nMDA receptor 206 98.08 Very High Very High Very High
cINOD 7 97.74 Very High Very High Very High
Pain 29 97.44 Very High Very High Very High
Thermal hyperalgesia 52 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 2 100.00 Very High Very High Very High
Adhesions 2 99.60 Very High Very High Very High
Stress Incontinence 20 99.28 Very High Very High Very High
Low Back Pain 4 97.44 Very High Very High Very High
Hyperalgesia 108 96.68 Very High Very High Very High
Nociception 56 95.96 Very High Very High Very High
Referred Pain 4 94.64 High High
Ulcers 2 86.24 High High
Pain 53 86.04 High High
INFLAMMATION 42 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity.
Positive_regulation (enhance) of Phosphorylation (Phosphorylation) of Src
1) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12754057 Disease Relevance 0.54 Pain Relevance 0.51
Interestingly, PDGF-BB treatment increased the phosphorylation of Src at both tyrosine 416 (tyrosine phosphorylation here potentiates Src activity) and 527 (tyrosine phosphorylation inhibits Src activity) [39].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Src
2) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.11
Interestingly, Takasu et al. (2002) showed that in primary cortical neurons in culture EphB activation by ephrinB2-Fc (immunoglobulin Fc fusion protein of ephrinB2) induced Src-dependent NR2B phosphorylation and furthermore we showed that intrathecal injection of ephrinB2-Fc induces Src phosphorylation in the spinal cord of adult rats (Battaglia et al., 2003).
Positive_regulation (induces) of Phosphorylation (phosphorylation) of Src in spinal cord associated with spinal cord and intrathecal
3) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.34 Pain Relevance 0.66
Src phosphorylation is required for phosphorylation of the NR2B subunit of the NMDA receptor and for induction of thermal hyperalgesia by ephrinB2.
Positive_regulation (required) of Phosphorylation (phosphorylation) of Src associated with thermal hyperalgesia and nmda receptor
4) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.97 Pain Relevance 0.92
Activation of Src kinase via the phosphorylation of tyrosine 416 is associated with a potentiation of NMDA receptor currents and an increase in long-term potentiation [40-42].
Positive_regulation (Activation) of Phosphorylation (phosphorylation) of Src associated with nmda receptor and long-term potentiation
5) Confidence 0.28 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.15
The increases in tyrosine phosphorylation at both the inhibitory and activation tyrosine residues of Src in the hippocampus suggest the intriguing possibility that two or more pools of Src may be present in neurons as well.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Src in neurons associated with hippocampus
6) Confidence 0.28 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.36
Phosphorylation levels of Src-family kinases bound to NR2B were significantly elevated following ephrinB2-Fc application onto the dorsal horn (Fig. 2A).
Positive_regulation (elevated) of Phosphorylation (Phosphorylation) of Src in dorsal horn associated with dorsal horn
7) Confidence 0.22 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.15 Pain Relevance 0.26
We have recently shown in the spinal cord an increase in the state of phosphorylation of non-receptor Src-family tyrosine kinases which were bound to EphB receptors “pulled-down” following ephrinB2 treatment (Battaglia et al., 2003).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Src in spinal cord associated with spinal cord
8) Confidence 0.20 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.10 Pain Relevance 0.17
Previously, we showed that selective delta-opioid agonists were able to induce the rapid tyrosine phosphorylation of delta-opioid receptors (delta-ORs) through Src.
Positive_regulation (induce) of Phosphorylation (phosphorylation) of Src associated with mu agonist and delta opioid receptors
9) Confidence 0.06 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10925143 Disease Relevance 0 Pain Relevance 0.31
We found MO instillation produced colon-urethra reflex sensitization along with an upregulation of endogenous ephrinB2 expression as well as phosphorylation of EphB 1/2, Src-family kinase, and NR2B tyrosine residues.
Positive_regulation (upregulation) of Phosphorylation (phosphorylation) of Src in urethra associated with stress incontinence
10) Confidence 0.03 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.27
All these results suggest that EphBR-ephrinB interactions, which provoke Src-family kinase-dependent NMDAR NR2B phosphorylation at the lumbosacral spinal cord level, are involved in cross-organ sensitization, contributing to the development of viscero-visceral referred pain between the bowel and the urethra.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of Src in urethra associated with stress incontinence, referred pain and spinal cord
11) Confidence 0.03 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.56 Pain Relevance 0.29
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Spec (whether) Positive_regulation (activation) of Phosphorylation (phosphorylation) of Src in external associated with stress incontinence and dorsal horn
12) Confidence 0.03 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.44 Pain Relevance 0.17
Using a wounded gastric epithelial cell monolayer model, we demonstrated that NSAIDs reduce both basal and epidermal growth factor (EGF)-induced re-epithelialization, and that this action involves disruption of actin stress fiber formation, reduced c-Src activity, decreased phosphorylation of focal adhesion kinase (FAK), tensin and their cellular re-distribution.
Positive_regulation (disruption) of Phosphorylation (phosphorylation) of Src in epithelial cell associated with stress, cinod and adhesions
13) Confidence 0.03 Published 2001 Journal Life Sci. Section Abstract Doc Link 11758831 Disease Relevance 0.75 Pain Relevance 0.58
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Spec (whether) Positive_regulation (activation) of in urethra Phosphorylation (phosphorylation) of Src in external associated with stress incontinence and dorsal horn
14) Confidence 0.01 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.44 Pain Relevance 0.17

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