INT89847

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.45
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
spinal cord 4
neuronal 2
bone marrow 2
synapses 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 14 100.00 Very High Very High Very High
Inflammatory mediators 10 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Spinal cord 6 96.56 Very High Very High Very High
imagery 10 83.28 Quite High
Inflammation 82 80.64 Quite High
cytokine 20 59.56 Quite High
Potency 3 48.08 Quite Low
Inflammatory response 4 27.60 Quite Low
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 54 100.00 Very High Very High Very High
Hypersensitivity 172 99.60 Very High Very High Very High
Nociception 12 88.08 High High
Pneumonia 42 81.04 Quite High
Immunization 4 70.64 Quite High
Muscular Dystrophy 15 48.00 Quite Low
Asthma 48 38.00 Quite Low
Pulmonary Disease 6 24.84 Low Low
Adhesions 6 17.52 Low Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization and regulation of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and soluble guanylyl cyclase (sGC) were assessed in the spinal cord of mice stimulated by an intraplantar injection of zymosan.
Positive_regulation (inducible) of Localization (localization) of neuronal nitric oxide synthase in spinal cord associated with spinal cord and neuronal nitric oxide synthase
1) Confidence 0.49 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.14 Pain Relevance 0.18
The localization and regulation of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and soluble guanylyl cyclase (sGC) were assessed in the spinal cord of mice stimulated by an intraplantar injection of zymosan.
Positive_regulation (inducible) of Localization (localization) of nNOS in spinal cord associated with spinal cord and neuronal nitric oxide synthase
2) Confidence 0.49 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.14 Pain Relevance 0.18
In contrast, estradiol caused an increase in IL-10 and NO release by cultured-BAL cells.
Positive_regulation (increase) of Localization (release) of NO
3) Confidence 0.49 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2936382 Disease Relevance 0.86 Pain Relevance 0.11
Conversely, whereas the P2X receptor antagonist PPADS and the P2Y antagonist reactive blue-2 partially inhibited increases in the translocation of nNOS and [Ca2+]i by ATP, the non-selective P2 receptor antagonist suramin completely blocked them.
Positive_regulation (increases) of Localization (translocation) of nNOS
4) Confidence 0.46 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
BACKGROUND: The translocation of neuronal nitric oxide synthase (nNOS) from the cytosol to the membrane is functionally coupled to the activation of N-methyl-D-aspartate (NMDA) receptors at synapses.
Positive_regulation (coupled) of Localization (translocation) of neuronal nitric oxide synthase in synapses associated with neuronal nitric oxide synthase
5) Confidence 0.46 Published 2009 Journal Molecular pain Section Abstract Doc Link 19619286 Disease Relevance 0.09 Pain Relevance 0.13
RESULTS: The translocation of nNOS was induced by ATP in the presence of NMDA and forskolin, an adenylate cyclase activator.
Positive_regulation (induced) of Localization (translocation) of nNOS
6) Confidence 0.46 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
Translocation of neuronal nitric oxide synthase to the plasma membrane by ATP is mediated by P2X and P2Y receptors.
Positive_regulation (mediated) of Localization (Translocation) of neuronal nitric oxide synthase in neuronal associated with pain and neuronal nitric oxide synthase
7) Confidence 0.46 Published 2009 Journal Molecular pain Section Title Doc Link 19619286 Disease Relevance 0.09 Pain Relevance 0.24
The purinergic P2X receptor agonist 2-MeSATP and the P2Y agonist UTP significantly enhanced nNOS translocation; and simultaneous stimulation with 2-MeSATP and UTP exhibited the same concentration-response curve for the translocation as obtained with ATP.
Positive_regulation (enhanced) of Localization (translocation) of nNOS
8) Confidence 0.46 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
We observed that cells collected of BAL and of bone marrow of OVx allergic rats significantly increased the release of inflammatory mediators such as LTB4, NO and TNF-?.
Positive_regulation (increased) of Localization (release) of NO in bone marrow associated with inflammatory mediators and hypersensitivity
9) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.13 Pain Relevance 0.18
In addition, the increase in the nNOS translocation by ATP was blocked by NMDA receptor antagonists and inhibitors of protein kinase A, protein kinase C, and Src kinase.
Positive_regulation (increase) of Localization (translocation) of nNOS
10) Confidence 0.40 Published 2009 Journal Molecular pain Section Body Doc Link 19619286 Disease Relevance 0 Pain Relevance 0
Therefore, we asked whether the current strategy for restoring dystrophin expression increased the level of nNOS protein localized at the myofiber membrane, where it serves to maintain normal cellular function in close association with dystrophin.
Positive_regulation (increased) of Localization (localized) of nNOS protein
11) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0

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