INT89852

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 14.89
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
Macrophage 3
MMA 3
spinal cord 2
brainstem 1
neuronal 1
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 251 100.00 Very High Very High Very High
cytokine 115 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
medulla 21 98.96 Very High Very High Very High
Neuropathic pain 22 98.04 Very High Very High Very High
Hippocampus 48 97.92 Very High Very High Very High
Spinal cord 61 97.68 Very High Very High Very High
Antinociceptive 5 94.84 High High
Inflammatory mediators 17 88.96 High High
antagonist 5 87.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 293 100.00 Very High Very High Very High
Cancer 222 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Targeted Disruption 229 99.52 Very High Very High Very High
Stress 19 98.64 Very High Very High Very High
Obesity 238 98.60 Very High Very High Very High
Neuropathic Pain 56 98.48 Very High Very High Very High
Death 32 98.44 Very High Very High Very High
Aids-related Complex 441 97.56 Very High Very High Very High
Sprains And Strains 227 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization and regulation of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and soluble guanylyl cyclase (sGC) were assessed in the spinal cord of mice stimulated by an intraplantar injection of zymosan.
Localization (localization) of iNOS in spinal cord associated with spinal cord and neuronal nitric oxide synthase
1) Confidence 0.78 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.14 Pain Relevance 0.18
Interestingly, we noticed that both the increased NOS-2 and GFAP staining were mostly found around capillary blood vessels of the hippocampus starting at an early stage.
Localization (staining) of NOS-2 in capillary associated with hippocampus
2) Confidence 0.71 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.61 Pain Relevance 0.30
In a first set of experiments, we assessed the influence of NOS1 or NOS2 deletion in the development and expression of peripheral neuropathic pain.
Localization (deletion) of NOS2 associated with neuropathic pain
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.36 Pain Relevance 0.20
On the other hand in vivo endomorphins had suppressive effect on NO release as well as on NOS 2 and IL-1 protein concentration.
Neg (NO) Localization (release) of NOS 2
4) Confidence 0.68 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20004470 Disease Relevance 0.16 Pain Relevance 0.26
The localization and regulation of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and soluble guanylyl cyclase (sGC) were assessed in the spinal cord of mice stimulated by an intraplantar injection of zymosan.
Localization (localization) of inducible nitric oxide synthase in spinal cord associated with spinal cord and neuronal nitric oxide synthase
5) Confidence 0.68 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.14 Pain Relevance 0.18
Taken together, ablation of iNOS improves the energy balance of ob/ob mice by decreasing energy intake (reduced food intake), and by increasing energy expenditure (increased rectal temperature).
Localization (ablation) of iNOS associated with obesity
6) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.53 Pain Relevance 0
It seems reasonable that the absence of iNOS may be associated to an increase in energy expenditure given that iNOS and DBKO mice exhibit a reduced body weight and fat mass as compared to their respective controls.
Neg (absence) Localization (absence) of iNOS in body associated with targeted disruption and body weight
7) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.09 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Localization (translocation) of iNOS associated with necrosis and cancer
8) Confidence 0.60 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
No increased gene expression was found for prostaglandin-endoperoxide synthase 2 (COX-2), nitric oxide synthase 2 (iNOS or NOS2), or glutathione-S-transferase Pi (GST-Pi) at the 2 day time point for either mouse strain exposed to MMA-SS fume (data not shown).
Localization (found) of nitric oxide synthase 2 in MMA associated with aids-related complex and sprains and strains
9) Confidence 0.59 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.63 Pain Relevance 0
No increased gene expression was found for prostaglandin-endoperoxide synthase 2 (COX-2), nitric oxide synthase 2 (iNOS or NOS2), or glutathione-S-transferase Pi (GST-Pi) at the 2 day time point for either mouse strain exposed to MMA-SS fume (data not shown).
Localization (found) of iNOS in MMA associated with aids-related complex and sprains and strains
10) Confidence 0.59 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.63 Pain Relevance 0
No increased gene expression was found for prostaglandin-endoperoxide synthase 2 (COX-2), nitric oxide synthase 2 (iNOS or NOS2), or glutathione-S-transferase Pi (GST-Pi) at the 2 day time point for either mouse strain exposed to MMA-SS fume (data not shown).
Localization (found) of NOS2 in MMA associated with aids-related complex and sprains and strains
11) Confidence 0.59 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.64 Pain Relevance 0
Inhibitory effects of these drugs on lipopolysaccharide (LPS)-induction of inducible nitric oxide synthase (iNOS) and LPS-stimulated translocation of NficB were determined by use of RAW 264.7 murine macrophages.
Localization (translocation) of iNOS in macrophages
12) Confidence 0.52 Published 2003 Journal Am. J. Vet. Res. Section Body Doc Link 12602591 Disease Relevance 0 Pain Relevance 0
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Localization (translocation) of inducible nitric oxide synthase associated with necrosis and cancer
13) Confidence 0.52 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
In addition, the same tissue was also dissected out from nNOS-, iNOS-, and eNOS-KO mice at 24 h after NS injection (NOS-KO control groups), and at 6, 16 and 24 h after CFA (NOS-KO CFA groups).
Localization (dissected) of iNOS associated with targeted disruption
14) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.49 Pain Relevance 0.11
The anti-inflammatory mechanisms of MOR(EtOH) appear to be related to the inhibition of neutrophil infiltration, iNOS and COX-2 protein expression, NO release, and the decreasing TNF-alpha level in serum.
Neg (NO) Localization (release) of iNOS in neutrophil
15) Confidence 0.49 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19576980 Disease Relevance 0 Pain Relevance 0
In HCT1026-fed mice, the generation of PHOX and iNOS-derived cytotoxic mediators, including 3-NT accumulation within DAergic neurons, were markedly abated, supporting that a significant proportion of SNpc neurons survived MPTP insult.
Localization (generation) of iNOS in neurons associated with parkinson's disease
16) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.78 Pain Relevance 0.36
Indeed, when microglia adopts a pro-inflammatory phenotype, the production and release of a plethora of toxic mediators, including pro-inflammatory cytokines and iNOS-derived NO, can enhance neuronal damage in the SNpc and accelerate the appearance of behavioral symptoms [32,81-83].
Localization (release) of iNOS in neuronal associated with inflammation and cytokine
17) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.76 Pain Relevance 0.22
We thus used immunohistochemistry to localize iNOS and 3-nitrotyrosine (3-NT) as fingerprint of iNOS-derived NO and peroxynitrite generation.
Localization (localize) of iNOS
18) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.80 Pain Relevance 0.10
By contrast, evidence supports the hypothesis that the NO synthesis derived from iNOS activity and its release, taking place within the brainstem, play a determinant role in the regulation of the sleep-wake states in SAMR1 aging normally [13,19].
Localization (release) of iNOS in brainstem associated with medulla and aging
19) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.90 Pain Relevance 0.13
-catenin nuclear accumulation in macrophage-infiltrated dysplastic mucosa of the K19-Wnt1 mouse stomach.
Localization (accumulation) of macrophage in stomach
20) Confidence 0.04 Published 2008 Journal EMBO J Section Abstract Doc Link PMC2413189 Disease Relevance 0.50 Pain Relevance 0

General Comments

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