INT89853

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 1.13
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Srgn) extracellular region (Srgn) Golgi apparatus (Srgn)
Anatomy Link Frequency
cardiomyocytes 3
neurons 1
small intestine 1
Srgn (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 7 98.62 Very High Very High Very High
Spinal cord 59 92.00 High High
antagonist 8 90.48 High High
tetrodotoxin 2 88.84 High High
Neuronal nitric oxide synthase 1 81.96 Quite High
TRP channel 6 79.68 Quite High
substance P 12 74.20 Quite High
allodynia 10 73.28 Quite High
Morphine 16 61.20 Quite High
imagery 20 44.64 Quite Low
Disease Link Frequency Relevance Heat
Nociception 40 99.60 Very High Very High Very High
Coronary Heart Disease 26 96.76 Very High Very High Very High
Targeted Disruption 17 95.32 Very High Very High Very High
Stomach Cancer 8 92.24 High High
Neuropathic Pain 23 73.28 Quite High
Natriuresis 10 50.00 Quite Low
Neurodegenerative Disease 24 46.92 Quite Low
Pain 42 36.08 Quite Low
Nervous System Injury 96 5.00 Very Low Very Low Very Low
Injury 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of sGC was not affected by zymosan treatment.
Gene_expression (Expression) of sGC
1) Confidence 0.44 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.17 Pain Relevance 0.17
Hence, these studies indicate that the NO/sGC/cGMP system acts as a negative modulator of both the cardiac contractile and hypertrophic responses to ?
Gene_expression (system) of sGC
2) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.19 Pain Relevance 0
In conclusion, our observations support the notion that cGMP synthesized by sGC (in response to NO) and membrane-bound GC-A (in response to ANP) does not feed a common cGMP pool in cardiac myocytes, but instead remains spatially and functionally compartmentalized to modulate different targets and thereby different myocyte functions.


Gene_expression (synthesized) of sGC in cardiac myocytes
3) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.17 Pain Relevance 0
In these studies we examined the time course of expression of 13 genes coding for components of this system including isoforms of the heme oxygenase (HO), nitric oxide synthase (NOS), soluble guanylate cyclase (sGC), cGMP dependent protein kinase (PKG) and phosphodiesterase (PDE) enzyme systems.
Spec (examined) Gene_expression (expression) of sGC
4) Confidence 0.17 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1310513 Disease Relevance 0.22 Pain Relevance 0.26
However, as the cells progressed toward differentiation, mRNA expression of sGC ?
Gene_expression (expression) of sGC
5) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.08 Pain Relevance 0
In addition to mRNA levels of different subunits, there was a concomitant increase in protein levels of sGC ?
Gene_expression (levels) of sGC
6) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.09 Pain Relevance 0
Our previous55 report provided the evidence that ESC-derived cardiomyocytes express a functional sGC enzyme that can be activated upon NO stimulation to produce cGMP.
Gene_expression (express) of sGC in cardiomyocytes
7) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.09 Pain Relevance 0
In summary, it was shown that there is a marked and time-dependent increase in the mRNA expression of both sGC subunits in differentiated cells relative to undifferentiated hESCs.
Gene_expression (expression) of sGC
8) Confidence 0.14 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.08 Pain Relevance 0
Soluble guanylyl cyclase (sGC) is a heme-containing, heterodimeric NO receptor that synthesizes cGMP.
Gene_expression (synthesizes) of sGC
9) Confidence 0.14 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0 Pain Relevance 0.03
Our studies indicated that there was a significant increase in the expression of sGC ?
Gene_expression (expression) of sGC
10) Confidence 0.14 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0.05 Pain Relevance 0
Soluble guanylyl cyclase can be activated by NO, which can bind up to 400-fold.56 Recently, we have demonstrated the differential expression of NO signaling components including NO synthase (NOS-1, -2, -3), their receptors (sGC ?
Gene_expression (expression) of sGC
11) Confidence 0.12 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0 Pain Relevance 0.03
Soluble guanylyl cyclase (sGC), a well-characterized molecular target of NO which causes an increase in intracellular cGMP in many cell types [4], is not expressed in DRG neurons [24].
Neg (not) Gene_expression (expressed) of sGC in neurons
12) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.11
NO from motor nerves is a potent inhibitory neurotransmitter that activates soluble guanylate cyclase (sGC) in the target cells. sGC is expressed in ICC-DMP of the rat small intestine [34] and almost all ICC in the guinea pig [20].
Gene_expression (expressed) of sGC in small intestine associated with neurotransmitter
13) Confidence 0.11 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.40
1), and protein kinase G in murine ESCs, ESC-derived cardiomyocytes, and for the first time in hESCs.56 We have previously demonstrated the role of the NO–cGMP signaling pathway in differentiation of human and mouse ESCs into myocardial cells by regulating the expression of the NO receptor, sGC.53,55,56

THE EXPRESSION PATTERNS OF sGC SUBUNITS IN hESC DIFFERENTIATION

Gene_expression (expression) of sGC in cardiomyocytes
14) Confidence 0.06 Published 2010 Journal Eplasty Section Body Doc Link PMC2885864 Disease Relevance 0 Pain Relevance 0

General Comments

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