INT89861

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.12
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
endothelium 1
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 5 97.68 Very High Very High Very High
Opioid 5 93.68 High High
Inflammation 28 70.52 Quite High
Serotonin 1 58.32 Quite High
opioid receptor 1 57.76 Quite High
substance P 22 43.92 Quite Low
Enkephalin 3 25.00 Low Low
Action potential 7 19.04 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 70.52 Quite High
Cancer 6 50.76 Quite High
Shock 2 38.40 Quite Low
Adhesions 2 26.92 Quite Low
Teratoma 4 24.76 Low Low
Apoptosis 4 24.32 Low Low
Death 3 16.28 Low Low
Cystitis 15 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Myocardial Infarction 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation, which has been previously reported [13], may be a result of proliferation of other cell types, epigenetic silencing of the specific Nkx2-5 enhancer element used in this set of experiments, and/or differentiation towards the vascular and smooth muscle endothelium cell lineages which downregulate Nkx2-5.
Negative_regulation (downregulate) of Nkx2-5 in endothelium
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Negative_regulation (preceded) of Nkx-2.5 associated with dynorphin
2) Confidence 0.18 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.56
However, the most striking finding of this analysis was the revelation that Nkx-2.5, a murine homeo box gene, is a unique discriminator of NK1R-dependent genes.
Negative_regulation (discriminator) of Nkx-2.5
3) Confidence 0.18 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox