INT89865

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 2.99
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
urinary bladders 1
cardiomyocytes 1
bladder 1
branchial arch 1
Mouse 1
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 10 99.52 Very High Very High Very High
substance P 132 97.44 Very High Very High Very High
Inflammation 168 94.72 High High
Opioid 10 93.68 High High
opioid receptor 2 76.16 Quite High
agonist 4 40.48 Quite Low
Serotonin 6 30.84 Quite Low
Enkephalin 6 25.00 Low Low
fibrosis 8 7.92 Low Low
Action potential 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 113 98.36 Very High Very High Very High
Targeted Disruption 44 98.20 Very High Very High Very High
Toxicity 2 96.96 Very High Very High Very High
INFLAMMATION 203 94.72 High High
Embryonic Lethality 2 94.04 High High
Natriuresis 12 92.80 High High
Disease 25 90.48 High High
Hyperplasia 12 83.96 Quite High
Cancer 38 78.36 Quite High
Muscular Dystrophy 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of DMSO, dynorphin B triggered GATA-4 and Nkx-2.5 gene expression and led to the appearance of both alpha-myosin heavy chain and myosin light chain-2V transcripts, two markers of cardiac differentiation.
Gene_expression (expression) of Nkx-2.5 associated with dynorphin
1) Confidence 0.75 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.64
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Gene_expression (expression) of Nkx-2.5 associated with dynorphin
2) Confidence 0.75 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.56
We and others have recently described the identification, isolation, and characterization of the novel mouse ESC-derived cardiac progenitor cells (CPCs) on the basis of Brachyury/Flk1 [11], Isl1/Flk1/Nkx2-5 [12], cKit/Nkx2-5 [13], or Nkx2-5 [14] expression.
Gene_expression (expression) of Nkx2-5
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.21 Pain Relevance 0
Prior to initiation of Nkx2-5 expression, coinciding with cardiac progenitor induction, the detection of Brachyury transcripts (day 4) indicated the formation of nascent mesoderm.
Gene_expression (expression) of Nkx2-5 in mesoderm
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.06 Pain Relevance 0
Other sites of Nkx-2.5 expression include pharyngeal endoderm and its derivatives, branchial arch epithelium, stomach, spleen, pancreas and liver [66].
Gene_expression (expression) of Nkx-2.5 in branchial arch
5) Confidence 0.33 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.37 Pain Relevance 0.03
Because of the high level of expression of both NKx-2.5 and NF-kappaB in the bladders pre-treated with saline, in an additional group, urinary bladders were removed without insertion of the catheter or fluid instillation.
Gene_expression (expression) of NKx-2.5 in urinary bladders
6) Confidence 0.33 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
With the exception of A10 (L21027) and EGF (J00380) that were associated with both matrixes, a unique set of genes is correlated with Nkx-2.5 matrix _01 and Nkx-2.5 matrix _02.


Gene_expression (matrix _02) of Nkx-2.5
7) Confidence 0.28 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
This group (0 hours) also presented a certain amount of shifted NKx-2.5 and NF-kappaB probes.
Gene_expression (probes) of NKx-2.5
8) Confidence 0.28 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.15 Pain Relevance 0.04
With the exception of A10 (L21027) and EGF (J00380) that were associated with both matrixes, a unique set of genes is correlated with Nkx-2.5 matrix _01 and Nkx-2.5 matrix _02.


Gene_expression (matrix) of Nkx-2.5
9) Confidence 0.28 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
We and others have recently described the identification, isolation, and characterization of the novel mouse ESC-derived cardiac progenitor cells (CPCs) on the basis of Brachyury/Flk1 [11], Isl1/Flk1/Nkx2-5 [12], cKit/Nkx2-5 [13], or Nkx2-5 [14] expression.
Gene_expression (expression) of Nkx2-5
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.22 Pain Relevance 0
We and others have recently described the identification, isolation, and characterization of the novel mouse ESC-derived cardiac progenitor cells (CPCs) on the basis of Brachyury/Flk1 [11], Isl1/Flk1/Nkx2-5 [12], cKit/Nkx2-5 [13], or Nkx2-5 [14] expression.
Gene_expression (expression) of Nkx2-5
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.22 Pain Relevance 0
Mouse ESCs were induced to differentiate in suspension forming aggregates termed embryoid bodies (EBs) and initial detection of GFP coincided with initiation of Nkx2-5 expression on differentiation day 5 (Figs. 1a, b).
Gene_expression (expression) of Nkx2-5 in Mouse
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.07 Pain Relevance 0
Because the Nkx2.5-Cre allele is not expressed in the endocardium, our results extend previous observations to suggest that calcineurin is required in myocardial cells to generate a morphologically correct valve, as well as for correct morphogenesis of the right ventricle.
Neg (not) Gene_expression (expressed) of Nkx2.5-Cre in myocardial cells
13) Confidence 0.22 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.26 Pain Relevance 0
The Nkx2.5-Cre allele is expressed very early in mouse heart development when the cardiac lineage is first specified, just before embryonic day 7.5 (27).
Gene_expression (expressed) of Nkx2.5-Cre in heart
14) Confidence 0.17 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.18 Pain Relevance 0
In the presence of NK1R, Nkx-2.5 _01 was significantly correlated with 36 transcripts which included several candidates for mediating bladder development (FGF) and inflammation (PAR-3, IL-1R, IL-6, NGF, TSP2) (Table 3, [additional file 3]).
Gene_expression (presence) of Nkx-2.5 in bladder associated with inflammation
15) Confidence 0.13 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.33 Pain Relevance 0.05
Consistent with this in vivo differentiation capacity, expression of core cardiac network mRNAs (GATA-4, Nkx2-5, isl-1, Mef2c, Hand2 and cardiac muscle actin) associated with skeletal and smooth muscle-specific mRNAs was detected in co-culture with embryonic cardiomyocytes.
Gene_expression (expression) of Nkx2-5 in cardiomyocytes
16) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.16 Pain Relevance 0
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Gene_expression (expression) of Nkx2-5
17) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0
Levels of NKX2-5 increased in cardiac tissue in a reversible transgenic mouse model for RNA toxicity [43].
Gene_expression (Levels) of NKX2-5 associated with targeted disruption and toxicity
18) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0

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