INT89867

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata4) DNA binding (Gata4) transcription factor binding (Gata4)
cell-cell signaling (Gata4)
Anatomy Link Frequency
P19 2
Gata4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 6 97.68 Very High Very High Very High
Opioid 5 94.12 High High
opioid receptor 1 57.76 Quite High
Enkephalin 5 25.00 Low Low
antagonist 16 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 3 86.00 High High
Repression 1 44.24 Quite Low
Embryonal Carcinoma 23 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Infarction 1 5.00 Very Low Very Low Very Low
Dysmenorrhea 1 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Negative_regulation (preceded) of Gene_expression (expression) of GATA-4 associated with dynorphin
1) Confidence 0.38 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.57
Here, we show that exposure of mouse ES cells to extremely low frequency magnetic fields triggered the expression of GATA-4 and Nkx-2.5, acting as cardiac lineage-promoting genes in different animal species, including humans.
Negative_regulation (triggered) of Gene_expression (expression) of GATA-4
2) Confidence 0.26 Published 2005 Journal FASEB J. Section Abstract Doc Link 15507470 Disease Relevance 0 Pain Relevance 0.04
In our previous studies in P19 cells, the GATA4 expression was only moderately reduced when l-NAME was administered together with OT, but the transcription factors MEF2c and Nkx2.5 were extensively downregulated.
Negative_regulation (reduced) of Gene_expression (expression) of GATA4 in P19
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.17 Pain Relevance 0

General Comments

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