INT89871

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 1.05
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gata4) DNA binding (Gata4) transcription factor binding (Gata4)
cell-cell signaling (Gata4)
Anatomy Link Frequency
P19 2
TEK 2
cardiomyocytes 1
fibroblast 1
embryonic cells 1
Gata4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 13 99.74 Very High Very High Very High
Opioid 10 94.12 High High
Kappa opioid receptor 1 79.28 Quite High
Kinase C 15 76.48 Quite High
opioid receptor 4 76.16 Quite High
Calcium channel 2 27.36 Quite Low
antagonist 33 25.00 Low Low
Enkephalin 10 25.00 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 124 98.36 Very High Very High Very High
Targeted Disruption 14 89.60 High High
Natriuresis 6 86.00 High High
Hyperplasia 6 79.36 Quite High
Injury 4 68.72 Quite High
Repression 2 44.24 Quite Low
Obesity 10 25.76 Quite Low
Infarction 10 9.48 Low Low
Embryonal Carcinoma 46 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of DMSO, dynorphin B triggered GATA-4 and Nkx-2.5 gene expression and led to the appearance of both alpha-myosin heavy chain and myosin light chain-2V transcripts, two markers of cardiac differentiation.
Gene_expression (expression) of GATA-4 associated with dynorphin
1) Confidence 0.69 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.64
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Gene_expression (expression) of GATA-4 associated with dynorphin
2) Confidence 0.69 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.56
Also by day 7,

GATA-4 is co-expressed with Cre in some of the cells in these clusters (Figure 8G–8I).

Gene_expression (expressed) of GATA-4
3) Confidence 0.56 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0
Here, we show that exposure of mouse ES cells to extremely low frequency magnetic fields triggered the expression of GATA-4 and Nkx-2.5, acting as cardiac lineage-promoting genes in different animal species, including humans.
Gene_expression (expression) of GATA-4
4) Confidence 0.48 Published 2005 Journal FASEB J. Section Abstract Doc Link 15507470 Disease Relevance 0 Pain Relevance 0.04
During the first 7 d in medium containing epidermal growth factor (EGF) and fibroblast growth factor (FGF), Spoc cells undergo several rounds of division, begin to express

GATA-4 (a mostly cardiac-specific transcription factor), and become clusters of floating round cardiac precursors from Spoc (CPS) cells with an increased diameter of 10–14 ?

Gene_expression (express) of GATA-4 in fibroblast
5) Confidence 0.43 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0.07 Pain Relevance 0
The differences in the expression of myogenic regulatory factors, MyoD and myogenin, as well as GATA4 and MEF-2, in response of P19 cells to OT and OT-GKR stimulation, can influence the developmental decisions of stem cells differentiating into the skeletal or cardiac muscle lineage.
Gene_expression (expression) of GATA4 in P19
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.14 Pain Relevance 0
In our previous studies in P19 cells, the GATA4 expression was only moderately reduced when l-NAME was administered together with OT, but the transcription factors MEF2c and Nkx2.5 were extensively downregulated.
Gene_expression (expression) of GATA4 in P19
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.17 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of GATA-4 in TEK
8) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of GATA-4 in TEK
9) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Lower relative expression of cardiomyogenic transcription factors, such as GATA-4, Nkx2-5, Isl-1, Mef2 and Hand2, was seen in clonal cell culture.
Gene_expression (expression) of GATA-4
10) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.36 Pain Relevance 0
Consistent with this in vivo differentiation capacity, expression of core cardiac network mRNAs (GATA-4, Nkx2-5, isl-1, Mef2c, Hand2 and cardiac muscle actin) associated with skeletal and smooth muscle-specific mRNAs was detected in co-culture with embryonic cardiomyocytes.
Gene_expression (expression) of GATA-4 in cardiomyocytes
11) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.16 Pain Relevance 0
The prodynorphin gene and its product, dynorphin B, have been found to promote cardiogenesis in embryonic cells by inducing the expression of GATA-4 and Nkx-2.5, two transcription factor-encoding genes essential for cardiogenesis.
Gene_expression (expression) of GATA-4 in embryonic cells associated with dynorphin
12) Confidence 0.04 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623877 Disease Relevance 0 Pain Relevance 0.29

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