INT8989

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Context Info
Confidence 0.36
First Reported 1981
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 5.52
Pain Relevance 14.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
brain 4
spinal cord 2
heart 2
striatum 1
central nervous system 1
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 21 100.00 Very High Very High Very High
opiate 17 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
Clonidine 25 99.92 Very High Very High Very High
fibrosis 4 99.90 Very High Very High Very High
Opioid 11 99.80 Very High Very High Very High
antagonist 9 99.78 Very High Very High Very High
dopamine receptor 11 99.76 Very High Very High Very High
opioid receptor 10 99.72 Very High Very High Very High
Spinal cord 7 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 10 100.00 Very High Very High Very High
Fibrosis 4 99.90 Very High Very High Very High
Coronary Heart Disease 15 99.64 Very High Very High Very High
Bordatella Infection 9 99.56 Very High Very High Very High
Glioma 4 99.00 Very High Very High Very High
Neuroblastoma 4 98.82 Very High Very High Very High
Hyperalgesia 20 97.12 Very High Very High Very High
Vibrio Infection 7 95.60 Very High Very High Very High
Ganglion Cysts 3 88.20 High High
Hypothermia 2 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart.
natriuretic peptide receptor Binding (binding) of in heart associated with natriuresis, fibrosis and coronary heart disease
1) Confidence 0.36 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.86 Pain Relevance 0.20
Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart.
NPR Binding (binding) of in heart associated with natriuresis, fibrosis and coronary heart disease
2) Confidence 0.36 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.86 Pain Relevance 0.20
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
cyclase Binding (binding) of in brain associated with neuroblastoma, glioma and clonidine
3) Confidence 0.36 Published 1981 Journal Eur. J. Biochem. Section Title Doc Link 6260485 Disease Relevance 0.37 Pain Relevance 0.82
Clonidine and several analogues of clonidine are shown to be useful probes for alpha 2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase.
cyclase Binding (binding) of associated with clonidine
4) Confidence 0.26 Published 1981 Journal Eur. J. Biochem. Section Abstract Doc Link 6260485 Disease Relevance 0.32 Pain Relevance 0.56
In the range of low concentrations ME appears to act on specific delta opioid receptors and its action is positively coupled to guanylate cyclase.
cyclase Binding (coupled) of associated with delta opioid receptors and enkephalin
5) Confidence 0.16 Published 1986 Journal Mol. Cell. Biochem. Section Abstract Doc Link 2421152 Disease Relevance 0 Pain Relevance 0.95
We previously demonstrated that chronic morphine induces a change in G protein coupling by the mu opioid receptor (MOR) from Gi/o to Gs, concurrent with the instatement of an interaction between Gbetagamma and adenylyl cyclase types II and IV.
cyclase Binding (interaction) of associated with mu opioid receptor and morphine
6) Confidence 0.11 Published 2006 Journal J. Neurobiol. Section Abstract Doc Link 16967511 Disease Relevance 0 Pain Relevance 0.84
These data suggest that the inhibitory effect of lidocaine on cAMP synthesis might involve a polar interaction with the Gi regulatory subunit of adenylate cyclase.
cyclase Spec (might) Binding (interaction) of associated with lidocaine
7) Confidence 0.11 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2537034 Disease Relevance 0.26 Pain Relevance 0.72
The QEHA fragment of type II adenylyl cyclase (50 microM), a peptide that binds to and inactivates betagamma, inhibited the maximal stimulation of adenylyl cyclase activity elicited by Leu-enkephalin (Leu-enk) by about 50%.
cyclase Binding (binds) of associated with enkephalin
8) Confidence 0.10 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10037449 Disease Relevance 0.09 Pain Relevance 0.33
Pharmacological characterization of the D2 dopamine receptor negatively coupled with adenylate cyclase in rat anterior pituitary.
cyclase Binding (coupled) of in anterior pituitary associated with dopamine receptor
9) Confidence 0.09 Published 1983 Journal Mol. Pharmacol. Section Title Doc Link 6306429 Disease Relevance 0 Pain Relevance 0.57
Interactions between opiate- and dopamine-induced effects on adenylate cyclase in rat striatum.
cyclase Binding (Interactions) of in striatum associated with dopamine, narcan and opiate
10) Confidence 0.09 Published 1986 Journal Eur. J. Pharmacol. Section Title Doc Link 3015643 Disease Relevance 0 Pain Relevance 0.82
The results suggest that activation of particulate or membrane bound guanylate cyclase potentiates NANCIS-induced decrease in Pp.
guanylate cyclase Binding (bound) of
11) Confidence 0.08 Published 1988 Journal Respir Physiol Section Abstract Doc Link 2902672 Disease Relevance 0.06 Pain Relevance 0.06
These observations suggest that the P23H model animal may be functionally impaired in the recovery state of biochemical reactions such as kinetics of Rho phosphorylation and dephosphorylation, binding of arrestin, and activities of guanylate cyclase and cGMP phosphodiesterase.
guanylate cyclase Binding (binding) of
12) Confidence 0.07 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.30 Pain Relevance 0
Nitric oxide is a newly recognized cell messenger for the activation of soluble guanylate cyclase and is produced from L-arginine by the enzyme nitric oxide synthase in a wide variety of tissues, including vascular endothelium and brain.
cyclase Binding (recognized) of in brain
13) Confidence 0.05 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1384399 Disease Relevance 0 Pain Relevance 0.22
In addition forskolin and NaF also stimulated adenylyl cyclase activity to a lesser degree in AV shunt rats compared with control rats.
cyclase Binding (activity) of
14) Confidence 0.05 Published 2000 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 11003579 Disease Relevance 0.18 Pain Relevance 0
Effect of low pH treatment on opioid peptides binding to their receptors and functional coupling of G-proteins to adenylyl cyclase in the rat spinal cord.
cyclase Binding (binding) of in spinal cord associated with analgesic, opioid and spinal cord
15) Confidence 0.05 Published 1996 Journal Peptides Section Title Doc Link 8804072 Disease Relevance 0 Pain Relevance 0.80
Withdrawal of morphine or [D-Ala2,N-methyl-Phe4,Gly-ol5]enkephalin following chronic treatment (by wash or addition of the antagonist naloxone) leads to an immediate increase in cyclase activity (supersensitization or overshoot), which is gradually reversed upon further incubation with naloxone.
cyclase Binding (leads) of associated with antagonist, narcan, enkephalin, withdrawal and morphine
16) Confidence 0.04 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 8530363 Disease Relevance 0 Pain Relevance 1.14
Activation of the adenylate cyclase cascade leads to phosphorylation of cyclase response element binding proteins (P-CREBs) which then bind CREs in these genes and induce transcription.
cyclase Binding (bind) of
17) Confidence 0.03 Published 1994 Journal Neuroreport Section Abstract Doc Link 7919167 Disease Relevance 0 Pain Relevance 0.11
However, in view of the consistent increase in the effect of morphine with phosphodiesterase inhibitors at higher doses, this hypothesis may be insufficient to account for opiate interactions with the adenylate cyclase system in the spinal cord.
cyclase Binding (interactions) of in spinal cord associated with opiate, spinal cord and morphine
18) Confidence 0.03 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1714608 Disease Relevance 0 Pain Relevance 1.25
In contrast, at the same time when morphine-induced effects on body temperature were assessed, no changes in pertussis toxin-mediated ADP-ribosylation of Gi(alpha)/Go(alpha), or basal adenylate cyclase activity, or binding of mu-opioid receptor selective ligand [3H]-DAMGO were observed in hypothalamic areas from rats treated with cholera toxin.
cyclase Binding (binding) of in body associated with bordatella infection, vibrio infection, opioid receptor and morphine
19) Confidence 0.02 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077589 Disease Relevance 0.79 Pain Relevance 0.75
Mu and delta opiate receptors in neuronal and astroglial primary cultures from various regions of the brain--coupling with adenylate cyclase, localisation on the same neurones and association with dopamine (D1) receptor adenylate cyclase.
cyclase Binding (brain--coupling) of in brain associated with dopamine and opiate
20) Confidence 0.02 Published 1991 Journal Neuropharmacology Section Title Doc Link 1663598 Disease Relevance 0 Pain Relevance 0.97

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