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Context Info
Confidence 0.70
First Reported 1968
Last Reported 2010
Negated 7
Speculated 0
Reported most in Abstract
Documents 122
Total Number 125
Disease Relevance 78.02
Pain Relevance 16.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
platelet 11
blood 9
plasma 5
skin 3
heart 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 187 99.86 Very High Very High Very High
fibrosis 17 99.60 Very High Very High Very High
aspirin 31 99.56 Very High Very High Very High
Demyelination 47 99.32 Very High Very High Very High
Angina 90 99.00 Very High Very High Very High
Nerve growth factor 14 98.64 Very High Very High Very High
imagery 29 98.46 Very High Very High Very High
antagonist 13 98.40 Very High Very High Very High
ischemia 27 98.26 Very High Very High Very High
metalloproteinase 11 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 59 100.00 Very High Very High Very High
Injury 272 99.98 Very High Very High Very High
Syndrome 26 99.98 Very High Very High Very High
Leg Ulcer 5 99.88 Very High Very High Very High
Pneumothorax 7 99.86 Very High Very High Very High
Acute-phase Reaction 3 99.84 Very High Very High Very High
INFLAMMATION 221 99.68 Very High Very High Very High
Myocardial Infarction 194 99.68 Very High Very High Very High
Coagulation Disorder 51 99.68 Very High Very High Very High
Empyema Thoracis 44 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The variant of fibrin glue produced with cryoprecipitation (concentration of coagulant protein not less than 60 g/l) was applied as reparation stimulator.
Gene_expression (produced) of fibrin
1) Confidence 0.70 Published 2006 Journal Khirurgiia (Mosk) Section Abstract Doc Link 17047628 Disease Relevance 0.41 Pain Relevance 0.08
Management of an extrasphincteric fistula in an HIV-positive patient by using fibrin glue: a case report with tips and tricks


Gene_expression (glue) of fibrin associated with fistula and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.66 Published 2010 Journal BMC Gastroenterol Section Title Doc Link PMC2829488 Disease Relevance 1.45 Pain Relevance 0.04
CLINICAL RELEVANCE: The alveolar macrophage has a key role in fibrin production.
Gene_expression (production) of fibrin in alveolar macrophage
3) Confidence 0.63 Published 1996 Journal Am. J. Vet. Res. Section Body Doc Link 8723878 Disease Relevance 0 Pain Relevance 0
Surface fibrin was present on the polypoid projections in 7 cases.
Gene_expression (present) of fibrin
4) Confidence 0.63 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17592279 Disease Relevance 2.64 Pain Relevance 0.30
[Fibrin glue for operative correction of septal deviations].
Gene_expression (glue) of Fibrin
5) Confidence 0.60 Published 2004 Journal HNO Section Title Doc Link 15338037 Disease Relevance 0.32 Pain Relevance 0.08
In the absence of biological tests and a posteriori the authors discuss the diagnosis of cryoglobulinaemia and intravascular disseminated coagulopathy; but in fact, these two syndromes produce very similar cutaneous symptoms, notably, cryofibrinogenaemias, cryofibrinogen being a degradation product of fibrin liberated in C.
Gene_expression (produce) of fibrin associated with cryoglobulinemia, coagulation disorder and syndrome
6) Confidence 0.60 Published 1977 Journal Rev Stomatol Chir Maxillofac Section Abstract Doc Link 270795 Disease Relevance 0.97 Pain Relevance 0.09
Skin biopsy of these lesions shows a characteristic vacuolated histiocytic infiltrate which contains Touton giant cells in 85% of the cases and a characteristic positivity of the lesions to factor XIIIa, CD68, CD163, fascin, and CD14 but negative S100 and CD1 on immunohistochemistry [10].
Neg (negative) Gene_expression (negative) of factor XIIIa in Skin
7) Confidence 0.58 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.27 Pain Relevance 0.17
Human Fibrin Glue (HFG) is made of two components contained in separate vials: a freeze dried concentrate of clotting proteins, mainly fibrinogen, Factor XIII and fibronectin (the sealant) and freeze dried thrombin (the catalyst).
Gene_expression (made) of Fibrin Glue associated with coagulation disorder
8) Confidence 0.56 Published 2003 Journal Acta bio-medica : Atenei Parmensis Section Abstract Doc Link 15055028 Disease Relevance 0.16 Pain Relevance 0
[Fibrin gluing in spontaneous pneumothorax].
Gene_expression (gluing) of Fibrin associated with pneumothorax
9) Confidence 0.54 Published 1989 Journal Pneumologie Section Title Doc Link 2470080 Disease Relevance 0.54 Pain Relevance 0.16
[Treatment of leg ulcers with fibrin glue].
Gene_expression (glue) of fibrin in leg associated with leg ulcer
10) Confidence 0.54 Published 1995 Journal Minerva Chir Section Title Doc Link 7501214 Disease Relevance 0.62 Pain Relevance 0.12
In conclusion, this is one of the first reports of the successful cessation of recurrent bleeding into a pseudocyst out of pseudoaneurysm ("Hemosuccus pancreaticus") by an ultrasound-guided transcutaneous fibrin glue and histoacryl/lipiodol application, which 1. is recommended as an alternative but feasible and safe therapeutic tool, 2. can provide sufficient and permanent cessation of bleeding but preserve the perfusion of the natural vessel as an initial step in the possible therapeutic algorithm, and 3. can avoid, in case of success, more invasive approaches such as angiography-guided embolization with coils or implantation of a prosthesis and even open surgical intervention, in particular, in high-risk patients.
Gene_expression (glue) of fibrin associated with hemorrhage and false aneurysm
11) Confidence 0.54 Published 2008 Journal Ultraschall Med Section Abstract Doc Link 18528810 Disease Relevance 0.96 Pain Relevance 0.13
CONCLUSIONS: The use of fibrin produces less postoperative pain in the first week, but prolongs operating time and increases costs.
Gene_expression (produces) of fibrin
12) Confidence 0.54 Published 2008 Journal Surg Endosc Section Body Doc Link 17943371 Disease Relevance 0 Pain Relevance 0
[Thoracoscopic treatment of spontaneous pneumothorax using fibrin pleurodesis].
Gene_expression (pleurodesis) of fibrin associated with pneumothorax
13) Confidence 0.54 Published 1992 Journal Zentralbl Chir Section Title Doc Link 1642048 Disease Relevance 0.70 Pain Relevance 0.25
These findings include the nephrotic syndrome, great variability in proteinuria and glomerular filtration rate, pulmonary embolization, sterile pyuria, hematuria, hyperchloremic acidosis, decreased renal tubular threshold for glucose and increased fibrin degradation products.
Gene_expression (products) of fibrin associated with acidosis, pyuria, proteinuria, hematuria and disorder of lipid metabolism
14) Confidence 0.54 Published 1977 Journal Am. J. Med. Section Abstract Doc Link 900143 Disease Relevance 0.73 Pain Relevance 0
As the use of the balloon has often been associated with a reduction in the number of circulating platelets and a pathological increase in the breakdow products of fibrin, heparin is now used systematically in an attempt to prevent the development of a true intravascular coagulation syndrome.
Gene_expression (products) of fibrin in platelets associated with syndrome and disseminated intravascular coagulation
15) Confidence 0.52 Published 1976 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 821419 Disease Relevance 0.53 Pain Relevance 0.13
When the two substances are combined with calcium chloride and applied topically, they produce a fibrin matrix that promotes hemostasis by mimicking the last step of the physiological coagulation cascade [13] and tissue adhesion by stimulating the exudative phase of wound healing [14].
Gene_expression (produce) of fibrin associated with wound healing and adhesions
16) Confidence 0.52 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2464595 Disease Relevance 0.62 Pain Relevance 0
CONCLUSION: Fibrin fixation of the mesh during laparoscopic transabdominal preperitoneal inguinal hernia repair is feasible without higher risk of recurrences.
Gene_expression (fixation) of Fibrin
17) Confidence 0.50 Published 2005 Journal Rozhl Chir Section Body Doc Link 16218348 Disease Relevance 0.06 Pain Relevance 0
Wound gapping in two eyes (5.6%) and transient graft edema in four eyes (11.2%) were observed, but no critical complications due to fibrin glue were observed including corneal defects, symblepharon, giant papillary conjunctivitis, granulation and contact dermatitis, previously proposed in other studies as possible complications.11,20,22
Gene_expression (glue) of fibrin in granulation associated with pressure and volume under development, conjunctiva disease, injury and contact dermatitis
18) Confidence 0.50 Published 2008 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629906 Disease Relevance 0.82 Pain Relevance 0.08
The purpose of this study is to reveal the efficacy and safety of using fibrin bioadhesive (Tissucol Duo Quick®, Baxter AG, Vienna, Austria) in place of sutures during conjunctivolimbal autograft surgery for primary pterygium in Korean patients.
Gene_expression (using) of fibrin in sutures associated with conjunctiva disease
19) Confidence 0.50 Published 2008 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629906 Disease Relevance 0.57 Pain Relevance 0
The presence of intra-alveolar fibrin in the form of fibrin "balls" and organizing pneumonia with patchy distribution are the main histological features of this entity.
Gene_expression (presence) of fibrin in balls associated with pneumonia
20) Confidence 0.49 Published 2006 Journal Rev Port Pneumol Section Abstract Doc Link 17117329 Disease Relevance 0.67 Pain Relevance 0.08

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