INT89926

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.12
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
monocytes 1
fibroblasts 1
PGE2 1
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 99.64 Very High Very High Very High
Inflammation 57 99.44 Very High Very High Very High
Arthritis 106 98.22 Very High Very High Very High
acular 3 97.46 Very High Very High Very High
chemokine 14 95.52 Very High Very High Very High
pulpitis 1 90.72 High High
antagonist 1 88.96 High High
metalloproteinase 9 75.00 Quite High
dexamethasone 8 69.76 Quite High
Pain 3 68.40 Quite High
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Muscular Dystrophy 6 100.00 Very High Very High Very High
Choroideremia 498 99.52 Very High Very High Very High
INFLAMMATION 61 99.44 Very High Very High Very High
Carcinoma 11 99.36 Very High Very High Very High
Epilepsy 5 99.16 Very High Very High Very High
Disease 46 99.00 Very High Very High Very High
Cancer 36 98.84 Very High Very High Very High
Prostate Cancer 41 98.64 Very High Very High Very High
Rheumatoid Arthritis 103 98.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth.
Neg (not) Regulation (affect) of IL-1alpha associated with cancer, acular and carcinoma
1) Confidence 0.60 Published 2000 Journal FASEB J. Section Abstract Doc Link 10928984 Disease Relevance 1.04 Pain Relevance 0.35
The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.
Regulation (regulation) of IL-1alpha in PGE2 associated with pulpitis
2) Confidence 0.44 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.47 Pain Relevance 0.34
We were thus able to confirm the role of ApoE, IL-1alpha and IL-1RA genes in TLE disease, but failed to confirm the involvement of IL-1beta and PDYN.
Regulation (role) of IL-1alpha associated with epilepsy and disease
3) Confidence 0.44 Published 2008 Journal Neurol. Sci. Section Abstract Doc Link 19066720 Disease Relevance 0.64 Pain Relevance 0
The present case-control study in Caucasian men found no significant effect of IL1A (-889 C>T) gene polymorphisms on prostate cancer risk.
Neg (no) Regulation (effect) of IL1A associated with prostate cancer
4) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2626602 Disease Relevance 1.25 Pain Relevance 0.22
CONCLUSION(S): This study revealed an imbalance between IL1beta and its decoy inhibitory receptor type 2 in women with endometriosis, which was particularly obvious in those who were infertile, and suggests that a defect in the local control of IL1 may be involved in the pathophysiology of endometriosis and related infertility.


Regulation (control) of IL1
5) Confidence 0.36 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17919610 Disease Relevance 0 Pain Relevance 0
In vivo effect of snake phospholipase A2 (crotoxin+cardiotoxin) on serum IL-1alpha, TNF-alpha and IL-1ra level in humans.
Regulation (effect) of IL-1alpha
6) Confidence 0.12 Published 2001 Journal Immunol. Lett. Section Title Doc Link 11137138 Disease Relevance 0.34 Pain Relevance 0.33
Patients with RA present constitutively high serum levels of pre-inflammatory cytokines, including TNF-, IL1 and IL6, which are NF-B target genes, suggesting activation of this pathway in the course of RA disease.
Regulation (target) of IL1 associated with inflammation, disease, cytokine and arthritis
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.99 Pain Relevance 0.42
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Regulation (deregulated) of IL1 associated with choroideremia
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.69 Pain Relevance 0.07
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of IL1 in monocytes associated with muscular dystrophy, choroideremia and adhesions
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.85 Pain Relevance 0
Functional categories affected in both fibroblasts and monocytes of CHM patients included a large group of genes involved in regulation of cell adhesion and motility (NCAM-2, FMN1, ANKRD28, CSF3R, DMD, MLLT4, DPP4, TSPAN5, CD114, DMD, CYFIP2, WNT5A, MMP7), immune response (IL1, CC2, CFI, ELOVL2), regulation of trafficking and exocytosis (RGS11, SYT 6, GBF1) and transcriptional regulation (HOXD11, MRO, NRG1, NLRC3, NR2F6, SALL1, DIP2A, RSOPO2) (Fig. 7A).
Regulation (regulation) of IL1 in fibroblasts associated with muscular dystrophy, choroideremia and adhesions
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.85 Pain Relevance 0

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