INT89928

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.78
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CSF2RA) plasma membrane (CSF2RA)
Anatomy Link Frequency
epithelial cells 1
salivary glands 1
guts 1
lung 1
heads 1
CSF2RA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 73 97.48 Very High Very High Very High
acular 3 97.10 Very High Very High Very High
chemokine 1 85.64 High High
cytokine 32 84.56 Quite High
anesthesia 4 83.76 Quite High
metalloproteinase 1 83.40 Quite High
Pain 4 76.56 Quite High
Angina 9 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 35 99.44 Very High Very High Very High
Pulmonary Disease 39 99.18 Very High Very High Very High
Carcinoma 10 99.00 Very High Very High Very High
INFLAMMATION 71 97.48 Very High Very High Very High
Acute Myeloid Leukemia 48 94.88 High High
Salivary Gland Disease 32 94.80 High High
Pulmonary Alveolar Proteinosis 306 93.76 High High
Lifespan 334 92.40 High High
Neurodegenerative Disease 13 88.80 High High
Acute Monocytic Leukemia 2 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PBMC co-expression of IL-2, MMP-13, CCR5 and IL-10, and potentially IL-4 and GM-CSF-R-alpha appears to be a promising, objective sign of lameness-related inflammatory foot lesions in dairy cattle.
Gene_expression (co-expression) of GM-CSF-R-alpha in PBMC associated with inflammation
1) Confidence 0.75 Published 2007 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 17675248 Disease Relevance 0.30 Pain Relevance 0.35
The father was heterozygous for mutant CSF2RAG174R and WT (CSF2RAWT) alleles (Fig. 3 A), whereas only the CSF2RAWT sequence was detected in the mother (Fig. 3 A).
Gene_expression (detected) of CSF2RAWT
2) Confidence 0.64 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.05 Pain Relevance 0
The father was heterozygous for mutant CSF2RAG174R and WT (CSF2RAWT) alleles (Fig. 3 A), whereas only the CSF2RAWT sequence was detected in the mother (Fig. 3 A).
Gene_expression (heterozygous) of CSF2RAG174R
3) Confidence 0.64 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.06 Pain Relevance 0
(E) Examples of rhabdomeres in flies expressing mutant huntingtin GMR-Q120 when PSA is downregulated using two RNAi lines (PSA-RNAi1 and PSA-RNAi2).


Gene_expression (expressing) of GMR in rhabdomeres
4) Confidence 0.58 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.41 Pain Relevance 0
Analysis of esgGal4, 5961GS and GMR-Gal4 expression pattern by western blot 5 females (esgGal4>UAS-GFP, 5961GS>UAS-GFP, GMRGal4>UAS-GFP or OregonR) were dissected into heads, guts, salivary glands, ovaries and the carcasses of the thorax and abdomen.
Gene_expression (expression) of GMR in guts associated with salivary gland disease
5) Confidence 0.58 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.34 Pain Relevance 0.08
To reproduce the GM-CSF receptor signaling defect identified in this family, plasmids expressing CSF2RB and either CSF2RAG174R or CSF2RAWT were cotransfected into 293 cells.
Gene_expression (expressing) of CSF2RAG174R
6) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.08 Pain Relevance 0.04
GM-CSF binding studies demonstrated that cells expressing CSF2RAWT and CSF2RB rapidly bound GM-CSF and removed it from the media, whereas cells expressing CSF2RAG174R and CSF2RB or CSF2RB alone did not clear GM-CSF (Fig. 4 B).
Gene_expression (expressing) of CSF2RAWT
7) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0 Pain Relevance 0
To reproduce the GM-CSF receptor signaling defect identified in this family, plasmids expressing CSF2RB and either CSF2RAG174R or CSF2RAWT were cotransfected into 293 cells.
Gene_expression (expressing) of CSF2RAWT
8) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.08 Pain Relevance 0.04
GM-CSF binding studies demonstrated that cells expressing CSF2RAWT and CSF2RB rapidly bound GM-CSF and removed it from the media, whereas cells expressing CSF2RAG174R and CSF2RB or CSF2RB alone did not clear GM-CSF (Fig. 4 B).
Gene_expression (expressing) of CSF2RAG174R
9) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0 Pain Relevance 0
BM transplantation and CSF2RA gene transfer represent other potentially therapeutic approaches.
Gene_expression (transfer) of CSF2RA
10) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.67 Pain Relevance 0
The father was heterozygous for mutant CSF2RAG174R and WT (CSF2RAWT) alleles (Fig. 3 A), whereas only the CSF2RAWT sequence was detected in the mother (Fig. 3 A).
Gene_expression (heterozygous) of CSF2RAWT
11) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.06 Pain Relevance 0
The slow progression and differences in severity of the lung disease between affected siblings with the same CSF2RA mutations and GM-CSF-R?
Gene_expression (mutations) of CSF2RA in lung associated with pulmonary disease
12) Confidence 0.56 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.86 Pain Relevance 0
Analysis of esgGal4, 5961GS and GMR-Gal4 expression pattern by western blot 5 females (esgGal4>UAS-GFP, 5961GS>UAS-GFP, GMRGal4>UAS-GFP or OregonR) were dissected into heads, guts, salivary glands, ovaries and the carcasses of the thorax and abdomen.
Gene_expression (expression) of GMR in salivary glands associated with salivary gland disease
13) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.34 Pain Relevance 0.08
Analysis of esgGal4, 5961GS and GMR-Gal4 expression pattern by western blot 5 females (esgGal4>UAS-GFP, 5961GS>UAS-GFP, GMRGal4>UAS-GFP or OregonR) were dissected into heads, guts, salivary glands, ovaries and the carcasses of the thorax and abdomen.
Gene_expression (expression) of GMR in heads associated with salivary gland disease
14) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.34 Pain Relevance 0.08
Analysis of esgGal4, 5961GS and GMR-Gal4 expression pattern by western blot 5 females (esgGal4>UAS-GFP, 5961GS>UAS-GFP, GMRGal4>UAS-GFP or OregonR) were dissected into heads, guts, salivary glands, ovaries and the carcasses of the thorax and abdomen.
Gene_expression (expression) of GMR in ovaries associated with salivary gland disease
15) Confidence 0.20 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.34 Pain Relevance 0.08
The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth.
Neg (not) Gene_expression (levels) of GM-CSF associated with cancer, acular and carcinoma
16) Confidence 0.17 Published 2000 Journal FASEB J. Section Abstract Doc Link 10928984 Disease Relevance 1.05 Pain Relevance 0.35
Flow cytometric immunophenotyping demonstrated expression of HLA-DR+/CD64+, CD36+/CD116+, CD14+/-, cCD68+, CD33++, CD13+/-, CD4+ and non expression of CD34, CD79a, CD20, CD10 and, CD3.
Gene_expression (expression) of CD116
17) Confidence 0.07 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.62 Pain Relevance 0
Flow cytometric immunophenotyping demonstrated expression of HLA-DR+/CD64+, CD36+/CD116+, CD14+/-, cCD68+, CD33++, CD13+/-, CD4+ and non expression of CD34, CD79a, CD20, CD10 and, CD3.
Gene_expression (expression) of CD116
18) Confidence 0.07 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.61 Pain Relevance 0
Increased expression of the GM-CSF gene is reported in human epithelial cells exposed to DEP; in humans exposed to short-term high levels of DEP similar to those encountered in a busy garage, bronchial biopsies showed increased GRO?
Gene_expression (expression) of GM-CSF gene in epithelial cells
19) Confidence 0.02 Published 2005 Journal Part Fibre Toxicol Section Body Doc Link PMC1280930 Disease Relevance 0.56 Pain Relevance 0.15

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