INT89936

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Tlr4) extracellular region (Il6)
plasma membrane (Tlr4) intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
brain 1
Tlr4 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 97.72 Very High Very High Very High
Inflammation 28 92.12 High High
chemokine 24 82.40 Quite High
Intracerebroventricular 1 76.72 Quite High
Inflammatory mediators 1 67.28 Quite High
cINOD 1 56.00 Quite High
halothane 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 93.52 High High
Pneumonia 21 92.12 High High
Shock 4 81.88 Quite High
Death 1 77.72 Quite High
INFLAMMATION 12 67.28 Quite High
Necrosis 1 66.84 Quite High
Cancer 1 66.48 Quite High
Bacterial Infection 1 63.20 Quite High
Neutropenia 5 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lps induces IL-6 in the brain and in serum largely through TNF production.
Lps Positive_regulation (induces) of IL-6 in brain
1) Confidence 0.49 Published 2000 Journal Cytokine Section Title Doc Link 10930297 Disease Relevance 0.06 Pain Relevance 0.09
LPS-induced elevations of serum TNF, IL-1, and IL-6 levels were also less in germfree mice [11, 12].
LPS Positive_regulation (elevations) of IL-6
2) Confidence 0.14 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.65 Pain Relevance 0.31
LPS-induced IL-6 was increased in the BALF of p50-deficient mice compared to WT.
LPS Positive_regulation (induced) of IL-6
3) Confidence 0.13 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.25 Pain Relevance 0.30

General Comments

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