INT89959

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 7.44
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglia 5
macrophages 4
paw 4
spleen 3
monocytes 3
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 123 100.00 Very High Very High Very High
allodynia 80 99.36 Very High Very High Very High
c fibre 17 99.00 Very High Very High Very High
withdrawal 49 95.44 Very High Very High Very High
Neuritis 21 93.16 High High
Spinal cord 92 91.72 High High
medulla 13 91.64 High High
Cannabinoid 9 91.32 High High
trigeminal ganglion 44 91.12 High High
Dorsal horn 48 90.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 100.00 Very High Very High Very High
Neuropathic Pain 130 99.36 Very High Very High Very High
Disease 141 98.84 Very High Very High Very High
Nervous System Injury 104 98.24 Very High Very High Very High
Demyelinating Disease 8 97.28 Very High Very High Very High
Neurodegenerative Disease 32 96.20 Very High Very High Very High
Brain Injury 3 95.20 Very High Very High Very High
Experimental Autoimmune Neuritis 21 94.12 High High
Ganglion Cysts 54 91.12 High High
Syndrome 2 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Augmented expression of daintain/allograft inflammatory factor-1 is associated with clinical disease: dynamics of daintain/allograft inflammatory factor-1 expression in spleen, peripheral nerves and sera during experimental autoimmune neuritis.
Positive_regulation (Augmented) of Gene_expression (expression) of daintain/allograft inflammatory factor-1 in spleen associated with inflammation, experimental autoimmune neuritis, disease and neuritis
1) Confidence 0.58 Published 2000 Journal Scand. J. Immunol. Section Title Doc Link 10931378 Disease Relevance 1.40 Pain Relevance 0.94
Regarding glial reactivity, we found an early microglial response, with the highest increase of isolectin B4 (IB4) and Iba1 expression at 3 days, and a slower and progressive response of astrocytes, shown by increasing expression of glial fibrillary acidic protein (GFAP) during the 28 days studied.
Positive_regulation (increase) of Gene_expression (expression) of Iba1 in IB4
2) Confidence 0.49 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0
For GFAP-, Iba1- and P2Y12- receptor immunostaining, the mean pixel intensity values were expressed as fold increase compared to the contralateral side of saline injected animals set to 1.0.
Positive_regulation (increase) of Gene_expression (expressed) of Iba1
3) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.36 Pain Relevance 0.44
We found that the expression of IBA-1 was increased by two-fold in the 6-OHDA-lesioned striatum and by 2.5-fold in the SN in comparison to the control group.
Positive_regulation (increased) of Gene_expression (expression) of IBA-1 in striatum
4) Confidence 0.33 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.66 Pain Relevance 0.16
A recent study shows that electrical stimulation at C-fiber intensity (10 mA, 5 min, 10 Hz) is sufficient to induce spinal Iba1 expression and mechanical allodynia without producing nerve injury.
Positive_regulation (induce) of Gene_expression (expression) of Iba1 in nerve associated with c fibre, nervous system injury and allodynia
5) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.96 Pain Relevance 1.16
Cooperation between Pu.1 and proteins binding to the interferon regulatory factor element appears to be necessary for both macrophage-specific and interferon gamma-inducible expression of the aif-1 gene.
Spec (appears) Positive_regulation (necessary) of Gene_expression (expression) of aif-1 in macrophage
6) Confidence 0.22 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11861656 Disease Relevance 0.19 Pain Relevance 0.13
Expression of iba-1 is enhanced when microglia is activated [33].
Positive_regulation (enhanced) of Gene_expression (Expression) of iba-1 in microglia
7) Confidence 0.21 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.26 Pain Relevance 0
Effect of CB1 and CB2 Receptor Blockade on spinal GFAP, Iba-1 and ED2/CD163 following Paw Incision
Positive_regulation (following) of Gene_expression (/) of Iba-1 in Paw
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.23
In order to examine expression of Iba-1 (a microglial marker), GFAP (an astrocytic marker), ED2/CD163 (a perivascular cell marker) and CB1/CB2 receptor and CB1/CB2 receptor co-localization with other cell markers in response to paw incision, untreated animals received paw incision surgery and were perfused as described below on days 1, 3 and 9 after surgery (n?
Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of Iba-1 in paw
9) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.07 Pain Relevance 0.13
Two-way ANOVA plus Bonferroni post tests when p<0.05 was used for comparisons between groups for Iba-1 or GFAP expression.
Positive_regulation (groups) of Gene_expression (expression) of Iba-1
10) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.09
Augmented expression of daintain/allograft inflammatory factor-1 is associated with clinical disease: dynamics of daintain/allograft inflammatory factor-1 expression in spleen, peripheral nerves and sera during experimental autoimmune neuritis.
Positive_regulation (Augmented) of in peripheral nerves Gene_expression (expression) of daintain/allograft inflammatory factor-1 in spleen associated with inflammation, experimental autoimmune neuritis, disease and neuritis
11) Confidence 0.20 Published 2000 Journal Scand. J. Immunol. Section Title Doc Link 10931378 Disease Relevance 1.40 Pain Relevance 0.94
In the present study, we also assessed the microglial marker IBA-1, which is specifically expressed in macrophages/microglia and is upregulated when these cells are activated [52].
Positive_regulation (upregulated) of Gene_expression (expressed) of IBA-1 in microglia
12) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.70 Pain Relevance 0.15
Expression of allograft inflammatory factor-1 (Aif-1), a 17-kDa protein bearing an EF-hand Ca(2+) binding motif, increases markedly in monocytes and macrophages participating in allo- and autoimmune reactions, including the perivascular inflammation in transplanted hearts, microglial infiltrates in experimental autoimmune neuritis, and the inflamed pancreas of prediabetic BB rats.
Positive_regulation (increases) of Gene_expression (Expression) of Aif-1 in monocytes associated with inflammation, experimental autoimmune neuritis and neuritis
13) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11861656 Disease Relevance 0.36 Pain Relevance 0.23
The IBa ratios after pretreatment with ?
Positive_regulation (pretreatment) of Gene_expression (ratios) of IBa
14) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0 Pain Relevance 0.07
In the present study, we also assessed the microglial marker IBA-1, which is specifically expressed in macrophages/microglia and is upregulated when these cells are activated [52].
Positive_regulation (upregulated) of in macrophages Gene_expression (expressed) of IBA-1 in microglia
15) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.70 Pain Relevance 0.15
Expression of allograft inflammatory factor-1 (Aif-1), a 17-kDa protein bearing an EF-hand Ca(2+) binding motif, increases markedly in monocytes and macrophages participating in allo- and autoimmune reactions, including the perivascular inflammation in transplanted hearts, microglial infiltrates in experimental autoimmune neuritis, and the inflamed pancreas of prediabetic BB rats.
Positive_regulation (increases) of in macrophages Gene_expression (Expression) of Aif-1 in monocytes associated with inflammation, experimental autoimmune neuritis and neuritis
16) Confidence 0.05 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11861656 Disease Relevance 0.36 Pain Relevance 0.23

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