INT89963

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 8.25
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
brain 7
T cell 2
liver 1
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 10 100.00 Very High Very High Very High
Endogenous opioid 10 99.86 Very High Very High Very High
addiction 7 99.46 Very High Very High Very High
opiate 15 99.26 Very High Very High Very High
withdrawal 15 99.12 Very High Very High Very High
agonist 7 98.32 Very High Very High Very High
Opioid 18 97.08 Very High Very High Very High
methadone 2 97.08 Very High Very High Very High
Morphine 6 93.88 High High
Paracetamol 1 92.76 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 5 99.46 Very High Very High Very High
Apoptosis 209 99.22 Very High Very High Very High
Death 92 99.00 Very High Very High Very High
Cognitive Disorder 5 98.24 Very High Very High Very High
Herpes Simplex Virus 36 96.64 Very High Very High Very High
Hepatitis 6 96.36 Very High Very High Very High
Cancer 161 94.56 High High
Liver Disease 1 94.20 High High
Infection 50 89.68 High High
Cervical Cancer 9 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the possible existence of endogenous opioid tones regulating the basal activities of Fas receptor forms and FADD in the brain, using gene-targeted mice lacking mu-, delta- or kappa-opioid peptide receptors (KO mice).
Regulation (regulating) of Fas in brain associated with endogenous opioid and opioid
1) Confidence 0.59 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.26 Pain Relevance 0.58
These data are in line with the acute opposite modulation of Fas and FADD induced by mu- and delta-opiate agonists, and strongly support the notion of an anti-apoptotic delta-opioid tone that restrains Fas signaling.
Regulation (modulation) of Fas associated with agonist, opiate, apoptosis and opioid
2) Confidence 0.59 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.25 Pain Relevance 0.56
We therefore examined the individual and combined roles of Bim and Fas in the T cell immune response to mouse ?
Spec (examined) Regulation (roles) of Fas in T cell
3) Confidence 0.44 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.25 Pain Relevance 0
This is supported by the finding that effects of Fas deficiency on deletion of activated T cells in vivo were observed most consistently when mice were administered several doses of SEB (Strasser et al., 1995).
Regulation (effects) of Fas in T cells
4) Confidence 0.44 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.41 Pain Relevance 0
The acute effects of opiate drugs and opiate addiction have been associated with modulation of Fas/FADD (Fas-Associated protein with Death Domain) signaling complex in the rat brain.
Regulation (modulation) of Fas in brain associated with addiction, opiate and death
5) Confidence 0.43 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.27 Pain Relevance 0.56
Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD.
Regulation (Effects) of Fas in brain associated with opioid receptor, opioid and death
6) Confidence 0.43 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17030115 Disease Relevance 0.34 Pain Relevance 0.61
Here, we have analyzed the effects of prolonged heroin administration on sensorimotor and cognitive performance in mice, as well as the associated changes in brain expression of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-X(L), Bad and Bax) apoptotic pathways.
Regulation (regulating) of Fas in brain associated with cognitive disorder and apoptosis
7) Confidence 0.40 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.71 Pain Relevance 0.12
To measure the effects of Fas deletion on androgen withdrawal induced regression of the prostate, both the organ size and rate of apoptosis have been measured in Fas-deficient (lpr) mice.
Regulation (effects) of Fas associated with apoptosis and withdrawal
8) Confidence 0.39 Published 2007 Journal BMC Urol Section Body Doc Link PMC1945027 Disease Relevance 0.36 Pain Relevance 0.05
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Regulation (regulating) of Fas in brain associated with apoptosis
9) Confidence 0.36 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Regulation (regulating) of Fas in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
10) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
Our results demonstrate that 2'-O-(2-methoxy)ethyl containing antisense oligonucleotides targeting Fas can exert in vivo pharmacological activity in liver, and suggest that oligonucleotide inhibitors of Fas may be useful in the treatment of human liver disease.
Regulation (targeting) of Fas in liver associated with liver disease
11) Confidence 0.27 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.55 Pain Relevance 0.09
This neurotoxic effect was accompanied by up-regulation of the proapoptotic proteins FasL, Fas, and Bad and the active fragments of caspases-8 and -3 in cortical and hippocampal lysates.
Regulation (regulation) of Fas
12) Confidence 0.23 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.50 Pain Relevance 0.59
We also found down-regulation of Fas, suggesting an alteration in the extrinsic apoptotic pathway.
Regulation (regulation) of Fas associated with apoptosis
13) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.35 Pain Relevance 0
Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD.
Regulation (Effects) of Fas in brain associated with opioid receptor, opioid and death
14) Confidence 0.19 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17030115 Disease Relevance 0.34 Pain Relevance 0.61
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Regulation (targeted) of FAS associated with apoptosis
15) Confidence 0.17 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.77 Pain Relevance 0
The Fas/CD95 was down regulated 2 fold in the cells expanded in presence of zVADfmk, and was reduced 2.75 times in the cultures expanded in the presence of zLLYfmk.
Regulation (regulated) of CD95
16) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.29 Pain Relevance 0

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