INT89964

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.62
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
liver 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 59.92 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 32 97.52 Very High Very High Very High
Disease 7 97.08 Very High Very High Very High
Hepatitis 12 92.00 High High
Attention Deficit Hyperactivity Disorder 1 86.04 High High
Apoptosis 6 84.16 Quite High
Death 7 80.32 Quite High
Congenital Anomalies 1 80.24 Quite High
Immune System Diseases 4 65.56 Quite High
Graft Vs Host Disease 2 62.64 Quite High
Aplastic Anemia 1 61.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Balb/c mice, dosing with ISIS 22023 reduced Fas mRNA and protein expressions in liver by 90%.
Negative_regulation (reduced) of Transcription (expressions) of Fas in liver
1) Confidence 0.58 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.74 Pain Relevance 0.06
MRL/lpr mice were generated by the insertion of the early transposable element ETn in the Fas gene, which causes a striking reduction in Fas mRNA expression and is associated clinically with marked acceleration of the lupus-like disease [39].
Negative_regulation (reduction) of Transcription (expression) of Fas associated with disease and systemic lupus erythematosus
2) Confidence 0.54 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.24 Pain Relevance 0
In tissue culture, this oligonucleotide induced a reduction in Fas mRNA expression that was both concentration- and sequence-specific.
Negative_regulation (reduction) of Transcription (expression) of Fas
3) Confidence 0.43 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.65 Pain Relevance 0

General Comments

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