INT89965

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.28
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
liver 2
mononuclear cells 1
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 5 99.22 Very High Very High Very High
rheumatoid arthritis 71 99.12 Very High Very High Very High
Osteoarthritis 1 95.48 Very High Very High Very High
Inflammation 33 92.48 High High
Morphine 3 92.04 High High
opioid receptor 4 90.24 High High
antagonist 2 87.80 High High
narcan 3 85.72 High High
Paracetamol 2 59.92 Quite High
chemokine 4 48.36 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 71 99.12 Very High Very High Very High
Systemic Lupus Erythematosus 32 97.52 Very High Very High Very High
Disease 9 97.08 Very High Very High Very High
Frailty 3 95.48 Very High Very High Very High
Apoptosis 56 93.52 High High
INFLAMMATION 34 92.48 High High
Hepatitis 17 91.48 High High
Death 13 91.48 High High
Hyperplasia 2 89.32 High High
Attention Deficit Hyperactivity Disorder 1 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Balb/c mice, dosing with ISIS 22023 reduced Fas mRNA and protein expressions in liver by 90%.
Transcription (expressions) of Fas in liver
1) Confidence 0.71 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.74 Pain Relevance 0.06
MRL/lpr mice were generated by the insertion of the early transposable element ETn in the Fas gene, which causes a striking reduction in Fas mRNA expression and is associated clinically with marked acceleration of the lupus-like disease [39].
Transcription (expression) of Fas associated with disease and systemic lupus erythematosus
2) Confidence 0.66 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.23 Pain Relevance 0
In tissue culture, this oligonucleotide induced a reduction in Fas mRNA expression that was both concentration- and sequence-specific.
Transcription (expression) of Fas
3) Confidence 0.53 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.65 Pain Relevance 0
In addition, the neutralization of opioid activity by naltrexone did not modify Fas mRNA expression in the liver as assessed with real-time quantitative polymerase chain reaction.
Transcription (expression) of Fas in liver associated with opioid
4) Confidence 0.45 Published 2004 Journal Hepatology Section Abstract Doc Link 15389866 Disease Relevance 0.73 Pain Relevance 0.96
Between 30% and 90% of cells in RA synovium are positive for Fas antigen, but Fas ligand (FasL) mRNA has been detected only in mononuclear cells in RA synovium [10].
Transcription (detected) of Fas in mononuclear cells associated with rheumatoid arthritis
5) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.93 Pain Relevance 0.43

General Comments

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