INT89969

Context Info Confidence 0.67 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 9 Disease Relevance 4.14 Pain Relevance 0.82

signal transduction (Sparc) extracellular space (Sparc) extracellular region (Sparc) proteinaceous extracellular matrix (Sparc) nucleus (Sparc) intracellular (Sparc)

Anatomy Link Frequency plasma 2 uterus 2 amygdala 1 Sparc (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 6 99.82 amygdala 4 98.92 withdrawal 1 97.56 Eae 1 77.84 ischemia 3 73.20 Parenteral administration 2 16.56 metalloproteinase 25 5.00 cva 15 5.00 cytokine 12 5.00 Inflammation 8 5.00

Disease Link Frequency Relevance Heat Obesity 3 99.84 Cancer 62 99.78 Atherosclerosis 6 99.72 Acute Coronary Syndrome 159 99.64 Coronary Artery Disease 45 99.36 Breast Cancer 54 96.72 Wound Healing 4 91.68 Myocardial Infarction 15 88.00 Fracture Healing 64 83.00 Aggression 2 75.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The morphine-induced increase in SPARC levels in the basolateral amygdala persisted after morphine withdrawal and coincided with the duration of locomotor sensitization.

Positive_regulation (increase) of SPARC in amygdala associated with withdrawal, amygdala and morphine

1) Confidence 0.67 Published 2000 Journal Nat. Med. Section Abstract Doc Link 10932229 Disease Relevance 0 Pain Relevance 0.78

Indeed, SPARC has been observed in atherosclerotic regions, and SPARC plasma levels were found to be elevated in obesity and CAD patients [37].

Positive_regulation (elevated) of SPARC in plasma associated with coronary artery disease, atherosclerosis and obesity

2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.74 Pain Relevance 0

SPARC is a matricellular glycoprotein transiently induced in the infarct, regulating cellular interactions and promoting matrix assembly.

Positive_regulation (induced) of SPARC

3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.47 Pain Relevance 0.04

In this context, preliminary studies on platelet-poor plasma (PPP) from NSTE-ACS patients, compared to matched chronic controls, suggest that circulating SPARC levels are increased in NSTE-ACS patients (not shown).

Positive_regulation (increased) of SPARC in plasma associated with acute coronary syndrome

4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.63 Pain Relevance 0

While the microarray data showed consistent, reproducible upregulation of COL3A1, BGN, SPARC and NID1 in IL11Ra-/- compared to wild type uterus, this effect was not statistically significant when real-time RT-PCR was used as an alternative quantitation method.

Positive_regulation (upregulation) of SPARC in uterus

5) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.06 Pain Relevance 0

The ECM genes COL3A1, SPARC, BGN and NID1 were among those upregulated in IL11Ra-/- uterus compared to wild type.

Positive_regulation (upregulated) of SPARC in uterus

6) Confidence 0.26 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0

As a result, the high affinity of SPARC for albumin is an albumin-cytotoxic uptake agent which serves to concentrate SPARC in the tumor.

Positive_regulation (concentrate) of SPARC associated with cancer

7) Confidence 0.19 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.18 Pain Relevance 0

These results demonstrated that the relative efficacy of nab-paclitaxel was significantly higher compared with polysorbate-based docetaxel in HER2-negative tumors and in HER2-positive tumors with high levels of SPARC.

Positive_regulation (levels) of SPARC associated with cancer

8) Confidence 0.18 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.76 Pain Relevance 0

Two other collagens and osteonectin were also found to be upregulated by EST analysis (Table 2).

Positive_regulation (upregulated) of osteonectin

9) Confidence 0.05 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.29 Pain Relevance 0

General Comments

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