INT89971

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Context Info
Confidence 0.80
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 10.25
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sparc) extracellular space (Sparc) extracellular region (Sparc)
proteinaceous extracellular matrix (Sparc) nucleus (Sparc) intracellular (Sparc)
Anatomy Link Frequency
platelets 5
connective 1
skin 1
lungs 1
amygdala 1
Sparc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 49 98.00 Very High Very High Very High
amygdala 4 97.60 Very High Very High Very High
fibrosis 133 97.56 Very High Very High Very High
chemokine 6 95.84 Very High Very High Very High
corticosteroid 8 95.56 Very High Very High Very High
Morphine 6 95.12 Very High Very High Very High
metalloproteinase 12 94.68 High High
withdrawal 1 81.60 Quite High
ischemia 6 78.32 Quite High
Eae 1 64.32 Quite High
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 85 99.82 Very High Very High Very High
Acute Coronary Syndrome 318 99.64 Very High Very High Very High
Cancer 65 99.48 Very High Very High Very High
Systemic Sclerosis 40 98.44 Very High Very High Very High
INFLAMMATION 55 98.00 Very High Very High Very High
Fibrosis 212 97.56 Very High Very High Very High
Syndrome 4 96.00 Very High Very High Very High
Disease 84 95.88 Very High Very High Very High
Pulmonary Fibrosis 32 92.92 High High
Coronary Artery Disease 91 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, SPARC (secreted protein, acidic and rich in cysteine), a matricellular component of the ECM, has been reported as a bio-marker for fibrosis in multiple fibrotic diseases, such as interstitial pulmonary fibrosis, renal interstitial fibrosis, cirrhosis, atherosclerotic lesions and scleroderma or systemic sclerosis (SSc) [4-9].
Localization (secreted) of SPARC associated with fibrosis, cirrhosis, atherosclerosis, pulmonary fibrosis, systemic sclerosis and disease
1) Confidence 0.80 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.51 Pain Relevance 0.31
Our in vivo application of SPARC siRNA demonstrated that inhibition of SPARC significantly reduced fibrosis in skin and lungs induced by bleomycin.
Localization (application) of SPARC siRNA in lungs associated with fibrosis
2) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.59 Pain Relevance 0.24
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Localization (secreted) of SPARC in platelets associated with acute coronary syndrome
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.68 Pain Relevance 0
Our data suggest a higher platelet secretion of SPARC in NSTE-ACS patients.
Localization (secretion) of SPARC in platelet associated with acute coronary syndrome
4) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.78 Pain Relevance 0
Ccl2: Chemokine (C-C motif) ligand 2, also known as monocyte chemotactic protein-1 (MCP-1); Col: collagen; Ctgf: connective growth factor; ECM: extracellular matrix; HE: hematoxylin and eosin; siRNA: small interfering RNA; SPARC: secreted protein, acidic and rich in cysteine; SSc: systemic sclerosis; TGF-?
Localization (secreted) of SPARC in connective associated with chemokine and systemic sclerosis
5) Confidence 0.70 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.79 Pain Relevance 0.13
Interestingly, the levels of platelet-secreted glycoprotein SPARC were decreased in platelets from NSTE-ACS patients as compared to stable controls, which is consistent with a platelet secretion associated to platelet activation in NSTE-ACS.
Localization (secreted) of SPARC in platelets associated with acute coronary syndrome
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.68 Pain Relevance 0
Platelet-secreted protein SPARC is down-regulated in platelets from NSTE-ACS patients
Localization (secreted) of SPARC in platelets associated with acute coronary syndrome
7) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.19 Pain Relevance 0
As mentioned above, one of the secreted proteins identified in our study was SPARC, which is primarily released from ?
Localization (released) of SPARC
8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.45 Pain Relevance 0.04
In that case, it would be also of interest to explore whether platelets release SPARC just after or before the acute event, which could be related to its primary physiological role in the disease.


Localization (release) of SPARC in platelets associated with disease
9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954807 Disease Relevance 0.76 Pain Relevance 0
Here we show that secreted protein acidic and rich in cysteine (SPARC), an anti-adhesive glycoprotein present in the basolateral amygdala, contributes to the establishment of locomotor sensitization.
Localization (secreted) of SPARC in amygdala associated with amygdala
10) Confidence 0.59 Published 2000 Journal Nat. Med. Section Abstract Doc Link 10932229 Disease Relevance 0 Pain Relevance 0.71
For collagen III and SPARC immunolocalization, all dilutions and washes were carried out in high salt Tris-buffered saline (HS-TBS, 300 mM NaCl, 5 mM TrisHCl) with 0.6 % Tween 20.
Localization (immunolocalization) of SPARC
11) Confidence 0.40 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Caveolin-2, SPARC, cortactin and dynamin 2 involved in the internalization of albumin may also be important in determining patient response to nab-paclitaxel.32,33
Localization (important) of SPARC
12) Confidence 0.33 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.12 Pain Relevance 0
Many tumors secrete into the tumor’s interstitium and onto the surface of the tumor cell, a protein known as secreted protein acidic and rich in cysteine (SPARC).
Localization (secreted) of SPARC associated with cancer
13) Confidence 0.28 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.25 Pain Relevance 0
Our in vivo application of SPARC siRNA demonstrated that inhibition of SPARC significantly reduced fibrosis in skin and lungs induced by bleomycin.
Localization (application) of SPARC siRNA in skin associated with fibrosis
14) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.59 Pain Relevance 0.24
-estradiol, in the meibomian gland include secreted acidic cysteine rich glycoprotein (regulates cell growth [71]), vascular endothelial growth factor A (promotes cell migration, among many other actions [71]), matrix metalloproteinase 3 (degrades fibronectin, laminin, gelatins and collagens [71]) and cathepsin K (degrades extracellular matrices [71]).
Localization (secreted) of acidic cysteine rich glycoprotein in meibomian gland associated with disorders of the lacrimal system and metalloproteinase
15) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.88 Pain Relevance 0.18

General Comments

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