INT89986

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Context Info
Confidence 0.56
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.35
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il6st) extracellular space (Il6st) cellular_component (Il6st)
Anatomy Link Frequency
peripheral nerve 2
DRG 1
nociceptors 1
Il6st (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 15 98.98 Very High Very High Very High
Pain 51 97.16 Very High Very High Very High
cytokine 52 94.88 High High
antinociception 6 93.40 High High
Calcitonin gene-related peptide 12 92.04 High High
c fibre 2 91.96 High High
Hyperalgesia 40 89.16 High High
hyperexcitability 12 87.36 High High
Sciatic nerve 2 86.84 High High
Neuropathic pain 3 83.60 Quite High
Disease Link Frequency Relevance Heat
Pain 45 97.16 Very High Very High Very High
Nociception 10 91.60 High High
Hyperalgesia 42 89.16 High High
Injury 71 85.20 High High
Neuropathic Pain 4 83.60 Quite High
Inflammatory Pain 2 82.56 Quite High
Nervous System Injury 3 81.44 Quite High
INFLAMMATION 56 77.80 Quite High
Arthritis 118 77.08 Quite High
Necrosis 6 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests a constitutive expression of signaling receptors for TNF and IL-1 beta and the signal transduction molecule gp130 but not IL-6 receptor or IL-8 receptor.
Gene_expression (expression) of gp130
1) Confidence 0.56 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10934280 Disease Relevance 0.55 Pain Relevance 0.94
We show that IL-6 in combination with its soluble receptor can sensitise nociceptors to heat and provide evidence for the constitutive expression of the signalling molecule gp130, but not of the IL-6-membrane-bound (specific) receptor, in nociceptors.
Neg (not) Gene_expression (expression) of gp130 in nociceptors associated with nociceptor
2) Confidence 0.55 Published 2002 Journal Pain Section Abstract Doc Link 11932061 Disease Relevance 0 Pain Relevance 0.57
Immunohistochemistry and Western blot analysis were used to determine levels of IL-6 and gp130 in DRG.
Spec (determine) Gene_expression (levels) of gp130 in DRG
3) Confidence 0.40 Published 2009 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 19330444 Disease Relevance 0.32 Pain Relevance 0.28
This sensitization is likely to be caused at least in part by a direct effect on the nerve fibres, because most peripheral nerve fibres were shown to express the transmembrane signal-transducing subunit gp130 [14,15].
Gene_expression (express) of gp130 in peripheral nerve
4) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.44 Pain Relevance 0.47
The induction of pain by IL-6 or IL-6/sIL-6R is likely to result directly from an action at peripheral neurones because most peripheral nerve fibres were shown to express the transmembrane signal-transducing subunit gp130 [14,15].
Gene_expression (express) of gp130 in peripheral nerve associated with pain
5) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.67 Pain Relevance 0.78
While there was no change in the expression of LIFR, the expression of gp130 and EGFR were elevated by 1.5- and 1.44-fold, respectively.
Gene_expression (expression) of gp130
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.14 Pain Relevance 0.03
Gene array analysis validated by QRT-PCR revealed an increase in the expression of LIF and TGFß1 as well as their corresponding receptors, LIFR, gp130 and AK5 in the SVZ at 7 days recovery from H/I.
Gene_expression (expression) of gp130
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.23 Pain Relevance 0.09

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