INT89992

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.11
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
cerebellum 4
cerebral cortex 2
brain 2
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 221 100.00 Very High Very High Very High
Glutamate 10 99.48 Very High Very High Very High
cerebral cortex 113 99.20 Very High Very High Very High
Intracerebroventricular 1 97.52 Very High Very High Very High
Eae 13 96.44 Very High Very High Very High
agonist 30 94.92 High High
Clonidine 3 94.60 High High
antagonist 19 94.28 High High
dopamine receptor 65 86.56 High High
gABA 27 82.68 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 100.00 Very High Very High Very High
Diabetes Mellitus 270 98.28 Very High Very High Very High
Cerebellar Diseases 9 90.64 High High
INFLAMMATION 3 77.88 Quite High
Schizophrenia 3 67.28 Quite High
Cognitive Disorder 33 65.84 Quite High
Disease 31 39.04 Quite Low
Congenital Anomalies 8 36.56 Quite Low
Stress 27 5.00 Very Low Very Low Very Low
Parkinson's Disease 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Participation of D1 dopamine and alpha2 adrenoreceptors in formation of the frequency spectrum of the cortical activity in rats].
Positive_regulation (formation) of Gene_expression ([Participation) of D1 dopamine associated with dopamine
1) Confidence 0.39 Published 2000 Journal Eksp Klin Farmakol Section Title Doc Link 10934587 Disease Relevance 0 Pain Relevance 0.53
Real Time-PCR analysis showed that the dopamine D1 receptor gene expression was significantly increased (p < 0.001) in the cerebral cortex and decreased (p < 0.001) cerebellum in diabetic condition.
Positive_regulation (increased) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with dopamine, diabetes mellitus and cerebral cortex
2) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.53 Pain Relevance 0.58
Gene expression studies using real time PCR showed an increased expression of dopamine D1 and D2 receptor in the cerebral cortex of diabetic rats.
Positive_regulation (increased) of Gene_expression (expression) of dopamine D1 in cerebral cortex associated with dopamine, diabetes mellitus and cerebral cortex
3) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.72 Pain Relevance 0.46
In our study, curcumin and insulin increased the dopamine D1 receptor expression levels in the cerebellum, which suggests that the curcumin supplementation influenced the functional regulation of these receptors to maintain normal dopaminergic function and this might also be involved as a mechanism of preventing cerebellar dysfunctions.
Positive_regulation (increased) of Gene_expression (expression) of dopamine D1 receptor in cerebellum associated with cerebellar diseases, dopamine and hyperinsulinism
4) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.86 Pain Relevance 0.56
In vitro patch clamp studies in rodent brain slices have suggested that activation of presynaptic D1LRs facilitates glutamate release (Hernandez et al., 2007) while activation of D2LRs reduces it (Hernandez et al., 2006).
Positive_regulation (activation) of Gene_expression (presynaptic) of D1LRs in brain associated with glutamate
5) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.40

General Comments

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