INT90

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 400
Total Number 432
Disease Relevance 137.67
Pain Relevance 113.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
stomach 28
neurons 21
neural 17
parietal cell 11
plasma 8
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 1173 100.00 Very High Very High Very High
antagonist 271 100.00 Very High Very High Very High
Cholecystokinin 213 100.00 Very High Very High Very High
Enkephalin 97 100.00 Very High Very High Very High
gABA 89 100.00 Very High Very High Very High
Neurotransmitter 78 100.00 Very High Very High Very High
Endogenous opioid 52 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
substance P 27 100.00 Very High Very High Very High
Opioid 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 429 100.00 Very High Very High Very High
Infection 258 100.00 Very High Very High Very High
Gastritis 117 100.00 Very High Very High Very High
Pain 19 100.00 Very High Very High Very High
Cancer 235 99.98 Very High Very High Very High
Neuroendocrine Cancer 38 99.96 Very High Very High Very High
Gastrinoma 118 99.92 Very High Very High Very High
Immunization 20 99.92 Very High Very High Very High
Fasciitis 9 99.92 Very High Very High Very High
Fibrosis 6 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transient nature of the response suggests that the vagus has not only a prompt stimulatory but also a slow inhibitory effect on gastrin release. 2) Although vagal denervation did not affect the gastrin response to anacidity, the TTX experiments revealed that both food-evoked and anacidity-evoked gastrin release depends on neural input.
Localization (release) of gastrin in neural associated with tetrodotoxin
1) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.24
We conclude that activated gastrin release, unlike basal gastrin release, is highly dependent on a neural input: 1) Vagal excitation has a transient stimulating effect on the G cells.
Localization (release) of gastrin in neural
2) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.25
We used microdialysis to monitor local gastrin release in response to food, acid blockade and acute vagal excitation.
Localization (release) of gastrin
3) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0
For the first time, gastrin release has been monitored continuously in intact conscious rats in a physiologically relevant experimental setting in a fashion that minimizes confounding systemic effects.
Localization (release) of gastrin
4) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0
Gastrin release: Antrum microdialysis reveals a complex neural control.
Localization (release) of Gastrin in neural
5) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Title Doc Link 20085791 Disease Relevance 0 Pain Relevance 0
In unilaterally vagotomized rats (fasted, 3 days post-op.), food evoked a prompt peak gastrin release followed by a gradual decline on the intact side.
Localization (release) of gastrin
6) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.12
We conclude that activated gastrin release, unlike basal gastrin release, is highly dependent on a neural input: 1) Vagal excitation has a transient stimulating effect on the G cells.
Localization (release) of gastrin in neural
7) Confidence 0.81 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20085791 Disease Relevance 0 Pain Relevance 0.25
These data suggest that endogenous opioids can contribute to vagal gastrin release provided the cholinergic restraint is blocked and adrenergic mechanisms stimulate endogenous opioids.
Localization (release) of gastrin associated with endogenous opioid
8) Confidence 0.81 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.79
Interaction between endogenous opioids, cholinergic and adrenergic mechanisms during vagally-induced gastrin release in rats.
Localization (release) of gastrin associated with narcan and endogenous opioid
9) Confidence 0.81 Published 1987 Journal Neuropeptides Section Title Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.62
Comparison of adrenergic and cholinergic receptor-mediated stimulation of gastrin release from rat antral fragments.
Localization (release) of gastrin
10) Confidence 0.81 Published 1988 Journal Peptides Section Title Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.20
Involvement of capsaicin-sensitive neurons in gastrin release provoked by intragastric administration of bile salts in the rat.
Localization (release) of gastrin in neurons associated with bile and qutenza
11) Confidence 0.81 Published 1995 Journal J. Gastroenterol. Section Title Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.71
Rat antral mucosal fragments were maintained in short-term culture to examine the relative potencies and receptor specificity of the cholinergic agonist, carbachol, and adrenergic agents, norepinephrine, isoproterenol, clonidine and phenylephrine in stimulating gastrin release.
Localization (release) of gastrin associated with agonist and clonidine
12) Confidence 0.81 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.20
This raises the possibility that endogenous opioids modulate gastrin release.
Localization (release) of gastrin associated with endogenous opioid
13) Confidence 0.81 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.34
Blockade of opiate receptors by naloxone had no effect on vagal gastrin release, however, the noncholinergic gastrin response was reduced significantly by naloxone, suggesting that cholinergic mechanisms normally restrain activation of endogenous opioids during vagal stimulation.
Localization (release) of gastrin associated with endogenous opioid, narcan and opiate
14) Confidence 0.81 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.82
To clarify the mechanism of gastrin release provoked by the reflux of bile juice into the stomach, we studied the effects of tetrodotoxin (0.08 mg/kg), atropine sulfate (0.5 mg/kg), truncal vagotomy, and chemical denervation of afferent sensory neurons with capsaicin (100 mg/kg) on gastrin release induced by bile salts in the rat (n = 6 per group).
Localization (release) of gastrin in bile associated with tetrodotoxin, bile and qutenza
15) Confidence 0.81 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.54
Adrenergic (norepinephrine, isoproterenol) stimulation of antral gastrin release was prevented by propranolol, and cholinergic- (carbachol) mediated peptide release was blocked by both atropine and pirenzepine.
Localization (release) of gastrin
16) Confidence 0.81 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.24
Phenylephrine and clonidine did not alter basal gastrin release.
Localization (release) of gastrin associated with clonidine
17) Confidence 0.81 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.24
Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release.
Localization (release) of gastrin in molar
18) Confidence 0.81 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.21
Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release.
Localization (release) of gastrin
19) Confidence 0.81 Published 1988 Journal Peptides Section Abstract Doc Link 3420006 Disease Relevance 0 Pain Relevance 0.21
To clarify the mechanism of gastrin release provoked by the reflux of bile juice into the stomach, we studied the effects of tetrodotoxin (0.08 mg/kg), atropine sulfate (0.5 mg/kg), truncal vagotomy, and chemical denervation of afferent sensory neurons with capsaicin (100 mg/kg) on gastrin release induced by bile salts in the rat (n = 6 per group).
Localization (release) of gastrin in sensory neurons associated with tetrodotoxin, bile and qutenza
20) Confidence 0.81 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox