INT90004

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.48
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TCF21) DNA binding (TCF21)
Anatomy Link Frequency
blood 2
monocytes 1
TCF21 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 58 97.60 Very High Very High Very High
epidural 4 89.80 High High
addiction 48 73.84 Quite High
Inflammatory response 32 73.36 Quite High
cytokine 20 70.56 Quite High
Pain 4 50.00 Quite Low
Inflammation 74 40.24 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 32 98.52 Very High Very High Very High
Anastomotic Leak 36 98.20 Very High Very High Very High
Systemic Inflammatory Response Syndrome 102 82.64 Quite High
Malignant Neoplastic Disease 8 77.28 Quite High
Esophageal Cancer 52 75.40 Quite High
Adult Respiratory Distress Syndrome 80 63.60 Quite High
Hypersensitivity 2 62.08 Quite High
Infection 10 50.80 Quite High
Pain 4 50.00 Quite Low
INFLAMMATION 84 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement and results: The maximal pain intensity was significantly higher on POD 1 and 2 (3.7 +/- 2 and 3.9 +/- 1.9, respectively) and lower on POD 3 and 7 (3.2 +/- 1.5 and 2.6 +/- 1.8, respectively).
Gene_expression (higher) of POD 1
1) Confidence 0.65 Published 2000 Journal Chest Section Body Doc Link 10936130 Disease Relevance 0 Pain Relevance 0
A peak of IL-10 in the AAS group occurred at T4 (mean ± SEM (standard error of the mean) = 30 ± 9 pg/ml; median = 15.0 pg/ml) and IL-10 could be still detected at POD1 (mean ± SEM = 23 ± 6 pg/ml, median = 17.5 pg/ml), whereas IL-10 was below the detection limit in most CAS patients.
Gene_expression (detected) of POD1
2) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.30
It can be seen that HLA-DR expression on CD14HIGH and CD14LOW monocytes at POD1 was decreased as shown by a leftward shift as compared to levels at T1.
Gene_expression (expression) of POD1 in monocytes associated with anesthesia
3) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.11 Pain Relevance 0.55
We hypothesized that the expression of certain proinflammatory genes would predict outcome, and in particular that POD 1 levels would help to identify patients at risk for anastomotic leak and pneumonia.
Gene_expression (levels) of POD 1 associated with anastomotic leak and pneumonia
4) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.84 Pain Relevance 0.09
Serum from whole blood was obtained intraoperatively and on POD 1, POD 3, POD 5 and POD 14.
Gene_expression (on) of POD 1 in blood
5) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.50
Furthermore, we expected that gene expression on POD 14 might predict mortality.
Gene_expression (expression) of POD 14
6) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.81 Pain Relevance 0.06
Serum from whole blood was obtained intraoperatively and on POD 1, POD 3, POD 5 and POD 14.
Gene_expression (on) of POD 14 in blood
7) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.50

General Comments

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