INT90026

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2000
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.98
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOXI2) transcription factor binding (FOXI2)
FOXI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 99.16 Very High Very High Very High
Morphine 9 98.60 Very High Very High Very High
agonist 39 94.80 High High
Crohn's disease 40 92.80 High High
antagonist 9 86.08 High High
Inflammation 5 83.28 Quite High
Enkephalin 4 82.60 Quite High
cytokine 3 63.92 Quite High
Dopamine 6 54.96 Quite High
Serotonin 8 27.72 Quite Low
Disease Link Frequency Relevance Heat
Fibromyalgia 2 98.84 Very High Very High Very High
Disease 38 92.80 High High
Targeted Disruption 5 92.08 High High
Disease Susceptibility 9 85.16 High High
Inflammatory Bowel Disease 5 83.28 Quite High
INFLAMMATION 2 69.28 Quite High
Acute Myeloid Leukemia 1 57.68 Quite High
Myelodysplastic Syndromes 1 55.20 Quite High
Bordatella Infection 1 30.16 Quite Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of Gbetagamma dimers, the affinities of DAMGO and endomorphin-1 and -2 were higher at hMOR-Galpha(i2) than at hMOR-Galpha(o1), whereas morphine displayed similar affinities at the two chimeras.
Gene_expression (higher) of i2 associated with morphine
1) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10936202 Disease Relevance 0 Pain Relevance 0.67
Of four Rs1-5HT1A chimeras (Figures 7, S4, S18, S19, S20, S21), only the two containing i2 and i3 from Rs1 were expressed at a level similar to that of Rs1 (Figure S5D).
Gene_expression (expressed) of i2
2) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.05 Pain Relevance 0.08
Two constructs encoding the human micro-opioid receptor (hMOR) fused at its C terminus to either one of two Galpha subunits, Galpha(o1) (hMOR-Galpha(o1)) and Galpha(i2) (hMOR-Galpha(i2)), were expressed in Escherichia coli at levels suitable for pharmacological studies (0.4-0.5 pmol/mg).
Gene_expression (expressed) of i2 associated with opioid receptor
3) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10936202 Disease Relevance 0 Pain Relevance 0.38
Two constructs encoding the human micro-opioid receptor (hMOR) fused at its C terminus to either one of two Galpha subunits, Galpha(o1) (hMOR-Galpha(o1)) and Galpha(i2) (hMOR-Galpha(i2)), were expressed in Escherichia coli at levels suitable for pharmacological studies (0.4-0.5 pmol/mg).
Gene_expression (one) of i2 associated with opioid receptor
4) Confidence 0.03 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10936202 Disease Relevance 0 Pain Relevance 0.35
In NIH3T3 cells expressing a dominant negative G alpha i2, Stat3 phosphorylation by v-fms (oncogenic CSF1R) was inhibited [21].
Neg (negative) Gene_expression (expressing) of i2 associated with fibromyalgia
5) Confidence 0.01 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.93 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox