INT90077

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 20.79
Pain Relevance 6.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
Microglia 2
monocytes 2
T cells 2
macrophages 1
neuronal 1
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 554 100.00 Very High Very High Very High
Inflammation 867 99.98 Very High Very High Very High
Central nervous system 93 99.52 Very High Very High Very High
Hyperalgesia 3 98.60 Very High Very High Very High
allodynia 4 97.92 Very High Very High Very High
Spinal cord 22 97.60 Very High Very High Very High
Sciatic nerve 3 95.88 Very High Very High Very High
Multiple sclerosis 17 94.80 High High
peripheral neuropathy 2 92.36 High High
antagonist 107 91.92 High High
Disease Link Frequency Relevance Heat
Apoptosis 160 100.00 Very High Very High Very High
INFLAMMATION 986 99.98 Very High Very High Very High
Targeted Disruption 58 99.88 Very High Very High Very High
Disease 429 99.80 Very High Very High Very High
Infection 107 99.46 Very High Very High Very High
Injury 156 99.24 Very High Very High Very High
Necrosis 52 99.20 Very High Very High Very High
Cancer 83 98.84 Very High Very High Very High
Hyperalgesia 15 98.60 Very High Very High Very High
Urological Neuroanatomy 26 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Immunohistochemical analysis revealed that activated caspase-1 and caspase-3 are present in neurons 24 hours after TBI.
Gene_expression (present) of caspase-1 in neurons
1) Confidence 0.76 Published 2001 Journal Neurosurgery Section Body Doc Link 11383749 Disease Relevance 0.17 Pain Relevance 0
Minocycline, a derivative of the antibiotic tetracycline, inhibits caspase-1 expression.
Gene_expression (expression) of caspase-1
2) Confidence 0.76 Published 2001 Journal Neurosurgery Section Abstract Doc Link 11383749 Disease Relevance 0.36 Pain Relevance 0.07
However, procaspase-1 was clearly detectable at the protein level in HCE-T cells, while no sign of its activation was observed, as also seen in unstimulated THP-1 cells (Figure 2C).
Gene_expression (detectable) of caspase-1 in T cells
3) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
and IL-18, it seems that caspase-1 action upon IL-33 produces an inactive form of this cytokine [17].
Gene_expression (action) of caspase-1 associated with cytokine
4) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.39 Pain Relevance 0.28
Recently, it was suggested that caspase-1 also metabolises another inflammatory mediator, IL-33; however, contrary to IL-1?
Gene_expression (metabolises) of caspase-1 associated with inflammation
5) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.35 Pain Relevance 0.25
By immunofluorescence or in situ fluorogenic substrate assay, caspase-1 and caspase-3 expression were detected in neuronal and non-neuronal cells following spinal cord injury.
Gene_expression (expression) of caspase-1 in neuronal associated with spinal cord
6) Confidence 0.63 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 1.00 Pain Relevance 0.43
The expression of caspase-1 was primarily observed in keratinocytes in the epidermal layer and in neutrophils deeper in the wounds.
Gene_expression (expression) of caspase-1 in keratinocytes
7) Confidence 0.60 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.11 Pain Relevance 0
Confocal microscopy was used to detect the expression of caspase-1 near the wounds.
Gene_expression (expression) of caspase-1
8) Confidence 0.60 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.17 Pain Relevance 0
can be cleaved by other proteases in addition to caspase-1, including elastase, proteinase 3 matrix metalloprotease 9 (MMP9), which are produced by neutrophils recruited to sites of tissue damage [20-23].
Gene_expression (produced) of caspase-1 in neutrophils
9) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.52 Pain Relevance 0.29
induced in the mice paw by carrageenin was similar in WT and casp1-/- (Figure 4D), the expression of mature IL-1?
Gene_expression (expression) of casp1 in paw
10) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.37 Pain Relevance 0.18
N-Benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone treated mice, and transgenic mice expressing a caspase-1 dominant negative mutant, demonstrated a significant improvement of motor function and a reduction of lesion size compared with vehicle-treated mice.
Neg (negative) Gene_expression (expressing) of caspase-1 associated with targeted disruption
11) Confidence 0.49 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 0.95 Pain Relevance 0.44
RT-PCR analysis showed increased expression of caspase-1, caspase-12 and caspase-8 genes in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve.
Gene_expression (expression) of caspase-1 in sciatic nerve associated with nervous system injury, urological neuroanatomy and sciatic nerve
12) Confidence 0.42 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.58 Pain Relevance 0.70
Microglia appear to be the earliest and major source of IL-1 after CNS injury, infection or inflammation, and they express caspase-1, the enzyme responsible for converting pro-IL-1?
Gene_expression (express) of caspase-1 in Microglia associated with inflammation, injury and infection
13) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.63 Pain Relevance 0.47
appeared to require two consecutive stimuli [29], with LPS stimulation in monocytes only producing pro-ICE and pro-IL-1?
Gene_expression (producing) of ICE in monocytes
14) Confidence 0.17 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.89 Pain Relevance 0.12
Microglia express ICE, and in response to injury are thought to produce both the initial burst and highest levels of IL-1 production [34].
Gene_expression (express) of ICE in Microglia associated with injury
15) Confidence 0.17 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 2.01 Pain Relevance 0.19
The cysteine protease, interleukin-converting enzyme (caspase-1), cleaves the 31–33 kDa precursor, proIL-1, to form the mature and biologically active IL-1?
Gene_expression (cysteine protease) of interleukin-converting enzyme
16) Confidence 0.16 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.09 Pain Relevance 0.21
The cysteine protease, interleukin-converting enzyme (caspase-1), cleaves the 31–33 kDa precursor, proIL-1, to form the mature and biologically active IL-1?
Gene_expression (cysteine protease) of caspase-1
17) Confidence 0.16 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.09 Pain Relevance 0.21
In addition, HCT1026 fed mice exhibited significantly reduced mRNA levels of pro-inflammatory cytokines, caspase-1, and iNOS in blood cells, with reduced number of CNS-infiltrating T cells [66].
Gene_expression (cytokines) of caspase-1 in T cells associated with inflammation and cytokine
18) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.96 Pain Relevance 0.17
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Gene_expression (producing) of ICE associated with targeted disruption
19) Confidence 0.15 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.78 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Gene_expression (producing) of ICE associated with targeted disruption
20) Confidence 0.15 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.78 Pain Relevance 0.13

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