INT90082

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Context Info
Confidence 0.04
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 6.09
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Degs1) oxidoreductase activity (Degs1) endoplasmic reticulum (Degs1)
lipid metabolic process (Degs1)
Degs1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 210 100.00 Very High Very High Very High
Dismenorea 15 93.60 High High
Clonidine 8 93.36 High High
agonist 1 72.40 Quite High
antidepressant 72 69.72 Quite High
Duloxetine 9 31.20 Quite Low
fluoxetine 18 28.04 Quite Low
sSRI 33 21.12 Low Low
Gabapentin 3 13.84 Low Low
sNRI 6 13.32 Low Low
Disease Link Frequency Relevance Heat
Depression 352 100.00 Very High Very High Very High
Endometriosis (extended) 144 96.84 Very High Very High Very High
Post-partum Depression 3 94.60 High High
Reprotox - General 1 18 93.60 High High
Recurrence 6 91.76 High High
Rigor 3 88.08 High High
Anxiety Disorder 27 86.48 High High
Psychosis 2 81.60 Quite High
Schizophrenia 1 80.08 Quite High
Reprotox - General 3 9 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence supports the contention that the perimenopause increases susceptibility to depression, particularly, but not necessarily, among women with life-long susceptibility to MDD, including those whose MDEs were induced by reproductive endocrine change (eg, during the premenstruum, pregnancy, or postpartum).


Positive_regulation (induced) of MDEs associated with depression
1) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971729 Disease Relevance 1.94 Pain Relevance 0.59
The increase in MDEs occurring at this time has been found to be linked to hormonal changes of the menopausal transition, namely increased FSH levels, rather than to social or environmental triggers, although changes in valued lifestyle factors associated with, for example, motherhood, family, fertility, or physical rigor and attractiveness, may precipitate depressive mood changes in predisposed or vulnerable women.
Positive_regulation (increase) of MDEs associated with depression, endometriosis (extended) and rigor
2) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971729 Disease Relevance 1.55 Pain Relevance 0.20
Evidence supports the contention that the perimenopause increases susceptibility to depression, particularly, but not necessarily, among women with life-long susceptibility to MDD, including those whose MDEs were induced by reproductive endocrine change (eg, during the premenstruum, pregnancy, or postpartum).


Positive_regulation (increases) of MDEs associated with depression
3) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971729 Disease Relevance 2.12 Pain Relevance 0.67
According to diagnostic categories, we found significantly lower GH stimulation in MDEs and in SADs compared to HCs or to SCZs.
Positive_regulation (stimulation) of MDEs
4) Confidence 0.02 Published 2000 Journal Psychoneuroendocrinology Section Abstract Doc Link 10938452 Disease Relevance 0.47 Pain Relevance 0.44

General Comments

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