INT90094

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 12.75
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Cytl1)
Anatomy Link Frequency
plasmas 1
leukocyte 1
neurons 1
spinal cord 1
Epithelial cells 1
Cytl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 116 100.00 Very High Very High Very High
COX2 2 99.82 Very High Very High Very High
allodynia 7 99.12 Very High Very High Very High
Paracetamol 166 98.84 Very High Very High Very High
Neurotransmitter 8 98.68 Very High Very High Very High
Spinal cord 5 98.08 Very High Very High Very High
Dopamine 37 87.08 High High
Inflammation 110 83.56 Quite High
tolerance 18 81.68 Quite High
Pain 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 216 100.00 Very High Very High Very High
Cancer 486 99.64 Very High Very High Very High
Leukemia 26 99.52 Very High Very High Very High
Glioma 10 99.14 Very High Very High Very High
Neuropathic Pain 8 99.12 Very High Very High Very High
Solid Tumor 10 98.96 Very High Very High Very High
Epstein-barr Virus 114 98.48 Very High Very High Very High
Malignant Neoplastic Disease 66 98.16 Very High Very High Very High
Disease 125 98.04 Very High Very High Very High
Obesity 124 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our experiments show that cortical neurons not only express the 2E1 isoform of cytochrome P-450, but also that AAP enhances its levels and activity after 18 h of treatment.
Gene_expression (express) of cyt in neurons associated with paracetamol
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000821 Disease Relevance 0.48 Pain Relevance 1.01
The aim of this study was to investigate whether transplantation of murine C17.2 NSCs alone or transfected with glial-derived neurotrophic factor (C17.2/GDNF) would induce allodynia in transplanted spinal cord-injured animals.
Gene_expression (transfected) of C17 in spinal cord associated with allodynia and spinal cord
2) Confidence 0.65 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16839548 Disease Relevance 0.76 Pain Relevance 0.64
Childhood glial tumor cells (but not normal cells) in the brain express the common leukocyte-associated antigen and Fas [273].
Gene_expression (express) of cyt in leukocyte associated with glioma
3) Confidence 0.58 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 2.24 Pain Relevance 0.06
Also, the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a regulator of the effector function of T cells, is expressed in various leukemias and solid tumors [304].
Gene_expression (expressed) of cyt in T cells associated with leukemia and solid tumor
4) Confidence 0.58 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 2.16 Pain Relevance 0.04
In contrast, low amounts of BART miRNAs were found in plasmas from mice carrying the C17 NPC.
Gene_expression (carrying) of C17 in plasmas associated with nasopharynx cancer
5) Confidence 0.21 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.38 Pain Relevance 0
High DNA copy numbers were obtained for C15, C666-1 and C17 but not CAPI mice (Table 1).
Neg (not) Gene_expression (obtained) of C17 associated with cancer
6) Confidence 0.21 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.39 Pain Relevance 0
Epithelial cells from the C15 and C17 NPC xenografts were dispersed by collagenase treatment and incubated in vitro for 48 h in order to produce conditioned culture media.
Gene_expression (xenografts) of C17 in Epithelial cells associated with nasopharynx cancer
7) Confidence 0.18 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.22 Pain Relevance 0
Therefore, we determined the cellular localization and temporal pattern of expression of P450(C17)and prostaglandin H synthase type 2 (PGHS-2), the primary PG synthetic enzyme, in intrauterine tissues from three groups of pregnant ewes at term; animals not in labour (NIL;n=5; 140-145 days of gestation), animals in early labour (EL;n=6; 143-149 days) and animals in active labour (L;n=6; 145-149 days).
Gene_expression (expression) of C17
8) Confidence 0.06 Published 2000 Journal Placenta Section Abstract Doc Link 10940197 Disease Relevance 0.06 Pain Relevance 0.06
Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P450(C17)in ovine placentomes with the natural onset of labour.
Gene_expression (expression) of C17 associated with cox2
9) Confidence 0.05 Published 2000 Journal Placenta Section Title Doc Link 10940197 Disease Relevance 0.07 Pain Relevance 0.12
Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease

Background

Gene_expression (overexpressing) of c17.2 in stem cells associated with disease
10) Confidence 0.03 Published 2007 Journal Mol Neurodegener Section Title Doc Link PMC2082017 Disease Relevance 0.68 Pain Relevance 0.03
NSCs expressing c17.2 and their derivatives constitutively secrete neurotrophic factors and partially differentiate into TH-positive cells
Gene_expression (expressing) of c17.2
11) Confidence 0.03 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2082017 Disease Relevance 0.08 Pain Relevance 0.08
In our previous work, we demonstrated that NTN-overexpressing c17.2 NSCs exerted dopaminergic neuroprotection in a rat model of PD.
Gene_expression (overexpressing) of c17.2 associated with disease
12) Confidence 0.03 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC2082017 Disease Relevance 0.71 Pain Relevance 0.03
However, in our study, c17.2 was transfected with NTN and Mock, which ranged from 5 to 9 passages and was not passaged at a comparably high confluence.
Gene_expression (transfected) of c17.2
13) Confidence 0.02 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2082017 Disease Relevance 0.13 Pain Relevance 0.30
Cytokine protein and prostaglandin E2 (PGE2) expression were measured by ELISA.
Gene_expression (expression) of Cytokine protein associated with cytokine
14) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2441623 Disease Relevance 1.39 Pain Relevance 0.44

General Comments

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