INT90097

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 6.14
Pain Relevance 6.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
retina 1
trophoblast cells 1
keratinocyte 1
mast cells 1
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 27 100.00 Very High Very High Very High
aspirin 2 100.00 Very High Very High Very High
COX2 10 99.90 Very High Very High Very High
cOX1 1 99.82 Very High Very High Very High
Inflammation 22 98.76 Very High Very High Very High
Morphine 166 98.60 Very High Very High Very High
spinal inflammation 11 97.98 Very High Very High Very High
Pain 26 96.68 Very High Very High Very High
addiction 6 96.32 Very High Very High Very High
rheumatoid arthritis 10 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 100.00 Very High Very High Very High
Colon Cancer 2 99.88 Very High Very High Very High
Anuria 2 98.94 Very High Very High Very High
Fever 3 98.44 Very High Very High Very High
Acute Renal Failure 3 98.20 Very High Very High Very High
Pyelonephritis 2 98.12 Very High Very High Very High
Low Back Pain 11 97.98 Very High Very High Very High
Pain 18 96.68 Very High Very High Very High
Syndrome 1 96.48 Very High Very High Very High
Rheumatoid Arthritis 10 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 selective inhibitors (COXIB or CSI) have been released with a fanfare as efficacious and safer alternatives to traditional non-steroidal anti-inflammatory drugs.
Localization (released) of Cyclooxygenase-2 associated with inflammation and cinod
1) Confidence 0.69 Published 2004 Journal Emerg Med Australas Section Abstract Doc Link 15239758 Disease Relevance 0.17 Pain Relevance 0.18
Cyclooxygenase-2 regulates renin-angiotensin secretion, and thereby glomerular filtration rate and sodium homeostasis.
Localization (secretion) of Cyclooxygenase-2
2) Confidence 0.61 Published 2001 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 11496053 Disease Relevance 0.09 Pain Relevance 0.07
In the presence of prostaglandin H synthetase, sulfite resulted in histamine release from mast cells.
Localization (presence) of prostaglandin H synthetase in mast cells
3) Confidence 0.57 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.48
Interestingly, reaction mixtures containing a typical peak morphine concentration (450 ng/ml) showed a significant increase in histamine release in the presence of prostaglandin H synthetase compared with no enzyme.
Localization (release) of prostaglandin H synthetase associated with morphine
4) Confidence 0.57 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 1.03
We suggest that the temporal relationship and subsequent co-localization of PGHS-2 and P450(C17)proteins in the uninucleate trophoblast cells of the placentomes are consistent with the possibility that placental PGs could act to enhance placental output of oestrogen leading to labour and delivery.
Localization (co-localization) of PGHS-2 in trophoblast cells
5) Confidence 0.52 Published 2000 Journal Placenta Section Abstract Doc Link 10940197 Disease Relevance 0.07 Pain Relevance 0.07
Various types of NSAIDs used in this study showed similar effects on the changes in PGD(2) release and PGHS-2 protein amounts, except those on PGHS activity in cell homogenates; while indomethacin, aspirin, and NS-398 inhibited it, but nimesulide and acetaminophen did not.
Localization (release) of PGHS-2 protein associated with aspirin, paracetamol and cinod
6) Confidence 0.47 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15256727 Disease Relevance 0.14 Pain Relevance 0.77
Therefore, we determined the cellular localization and temporal pattern of expression of P450(C17)and prostaglandin H synthase type 2 (PGHS-2), the primary PG synthetic enzyme, in intrauterine tissues from three groups of pregnant ewes at term; animals not in labour (NIL;n=5; 140-145 days of gestation), animals in early labour (EL;n=6; 143-149 days) and animals in active labour (L;n=6; 145-149 days).
Spec (determined) Localization (localization) of prostaglandin H synthase type 2
7) Confidence 0.46 Published 2000 Journal Placenta Section Abstract Doc Link 10940197 Disease Relevance 0.07 Pain Relevance 0.07
Therefore, we determined the cellular localization and temporal pattern of expression of P450(C17)and prostaglandin H synthase type 2 (PGHS-2), the primary PG synthetic enzyme, in intrauterine tissues from three groups of pregnant ewes at term; animals not in labour (NIL;n=5; 140-145 days of gestation), animals in early labour (EL;n=6; 143-149 days) and animals in active labour (L;n=6; 145-149 days).
Spec (determined) Localization (localization) of PGHS-2
8) Confidence 0.46 Published 2000 Journal Placenta Section Abstract Doc Link 10940197 Disease Relevance 0.07 Pain Relevance 0.07
BACKGROUND AND AIMS: Cyclooxygenase 2 (COX-2) is a target of aspirin and other non-steroidal anti-inflammatory drugs and is implicated in the pathogenesis of colorectal cancer.
Localization (implicated) of Cyclooxygenase 2 associated with aspirin, inflammation, colon cancer, cinod and cox2
9) Confidence 0.41 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15167166 Disease Relevance 0.35 Pain Relevance 0.20
Here, we report the case of a previously healthy woman with reversible acute renal failure associated with eight days of anuria following the administration of valdecoxib, a newly released selective cyclooxygenase-2 inhibitor, during an episode of acute febrile pyelonephritis.
Localization (released) of cyclooxygenase-2 associated with acute renal failure, anuria, pyelonephritis and fever
10) Confidence 0.22 Published 2005 Journal Clin. Nephrol. Section Abstract Doc Link 15786824 Disease Relevance 0.55 Pain Relevance 0.25
The recent release of selective cyclooxygenase-2 (COX-2) inhibitors has been associated with a decrease in adverse gastrointestinal effects.
Localization (release) of cyclooxygenase-2
11) Confidence 0.22 Published 2005 Journal Clin. Nephrol. Section Abstract Doc Link 15786824 Disease Relevance 0.46 Pain Relevance 0.26
The robust evidence of strong TRPV1 expression in keratinocytes9 has led to the belief that keratinocytes are capable of functioning as one of the main thermosensory receptors.19 Studies using cultured human epidermal keratinocytes have confirmed that expressed TRPV1 responds to heat and noxious stimuli20 and that activation of epidermal keratinocyte TRPV1 results directly in release of cyclooxygenase-2, one of the main mediators of inflammation.21
Localization (release) of cyclooxygenase-2 in keratinocyte associated with inflammation
12) Confidence 0.21 Published 2007 Journal Histopathology Section Body Doc Link PMC2121152 Disease Relevance 0.71 Pain Relevance 0.38
In AS, NSAIDs, potentially especially coxibs, may even prevent new bone formation due to their inhibitory effect on cyclooxygenase-2.
Localization (effect) of cyclooxygenase-2 associated with spinal inflammation and cinod
13) Confidence 0.14 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 19822062 Disease Relevance 2.03 Pain Relevance 1.50
Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina.
Localization (localization) of cyclooxygenase-2 in retina associated with cox1
14) Confidence 0.11 Published 2002 Journal J. Comp. Neurol. Section Title Doc Link 12355421 Disease Relevance 0.37 Pain Relevance 0.28
The recent release of the selective cyclooxygenase-2 (COX-2) enzyme inhibitors for the treatment of various inflammatory disorders and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects.
Localization (release) of cyclooxygenase-2 associated with pain, inflammation and syndrome
15) Confidence 0.06 Published 2001 Journal Int Urol Nephrol Section Abstract Doc Link 12452607 Disease Relevance 0.57 Pain Relevance 0.43
The observation that both the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthetase are markedly affected by GSH and GSH peroxidase [35], has catalyzed significant interest in connection with this process.
Localization (isoforms) of prostaglandin H2 synthetase
16) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.14 Pain Relevance 0.07
The question of how in the presence of adequate PUFA precursors the constitutive and inducible forms of prostaglandin H synthetase can be induced to generate the appropriate forms of prostaglandin required to maintain tissue homeostasis will rely on further understanding of the co-factors and feedback mechanisms involved.
Localization (forms) of prostaglandin H synthetase
17) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.17 Pain Relevance 0.09
[Clinical application of cyclooxygenase-2 inhibitors].
Localization (application) of cyclooxygenase-2 associated with cox2
18) Confidence 0.04 Published 2001 Journal Pol. Merkur. Lekarski Section Title Doc Link 11503270 Disease Relevance 0.18 Pain Relevance 0.43

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