INT9011

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Context Info
Confidence 0.30
First Reported 1981
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 2.35
Pain Relevance 12.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 3
medulla 2
brain 2
urinary bladder 1
anterior 1
Nrtim1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
substance P 17 100.00 Very High Very High Very High
Dynorphin 12 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
Somatostatin 4 99.88 Very High Very High Very High
qutenza 31 99.84 Very High Very High Very High
Morphine 19 99.66 Very High Very High Very High
tramadol 32 99.28 Very High Very High Very High
Spinal cord 14 99.28 Very High Very High Very High
medulla 11 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Shock 2 99.48 Very High Very High Very High
Stress 8 98.16 Very High Very High Very High
Fever 3 97.16 Very High Very High Very High
Disease 3 96.32 Very High Very High Very High
Sudden Infant Death Syndrome 8 95.92 Very High Very High Very High
Nicotine Addiction 2 94.36 High High
Toxocariasis 2 93.48 High High
Injury 4 88.24 High High
Overactive Bladder 2 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.
Negative_regulation (loss) of immunoreactivity associated with qutenza and substance p
1) Confidence 0.30 Published 1999 Journal Life Sci. Section Title Doc Link 10210268 Disease Relevance 0 Pain Relevance 0.94
Pretreatment with capsaicin (2.5, 5 and 10 mg/kg, s.c.) induced the functional desensitization and the loss of substance P-like immunoreactivity (SP-LI) with a similar potency (ED50: 3.31 +/- 0.57 and 4.81 +/- 0.89 mg/kg, respectively) in isolated guinea-pig bronchi.
Negative_regulation (loss) of immunoreactivity associated with qutenza, potency and substance p
2) Confidence 0.30 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210268 Disease Relevance 0 Pain Relevance 0.64
The substance P-like immunoreactivity (SP-LI) of the urinary bladder of adult rats was depleted by capsaicin desensitization (50 mg/kg, s.c., 4 days before) or extrinsic denervation (pelvic ganglionectomy) thus indicating its neurogenic sensory origin.
Negative_regulation (depleted) of immunoreactivity in urinary bladder associated with qutenza, ganglionectomy and substance p
3) Confidence 0.30 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 2438608 Disease Relevance 0.16 Pain Relevance 0.43
Somatostatin-like immunoreactivity (SST-LI) of rat thymus, eluting in part as authentic SST, was unaffected both by capsaicin or 6-OHDA pretreatment.
Neg (unaffected) Negative_regulation (unaffected) of immunoreactivity in thymus associated with qutenza and somatostatin
4) Confidence 0.30 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2445006 Disease Relevance 0 Pain Relevance 0.75
We examined the ability of tramadol, its enantiomers, and morphine as reference to suppress c-fos-like immunoreactivity (c-fos-ir) in rat spinal cord and brain regions following a noxious stimulus (i.p. administration of 3.5% acetic acid). c-fos-ir was measured by immunocytochemistry and the stained cells in each region were counted 2 h after the acetic-acid injection (2:25 h after tramadol or morphine).
Negative_regulation (suppress) of immunoreactivity in brain associated with tramadol, spinal cord and morphine
5) Confidence 0.03 Published 1998 Journal Eur J Pain Section Abstract Doc Link 15102381 Disease Relevance 0 Pain Relevance 1.38
Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus.
Negative_regulation (suppress) of immunoreactivity in brain associated with tramadol and spinal cord
6) Confidence 0.03 Published 1998 Journal Eur J Pain Section Title Doc Link 15102381 Disease Relevance 0 Pain Relevance 1.29
Increasing doses of L-HCA injected into the anterior striatum resulted in dose-dependent reductions in both substance P-like immunoreactivity (SP-LI) and gamma-aminobutyric acid (GABA) while there was a relative sparing of both somatostatin-like immunoreactivity (SS-LI) and neuropeptide Y-like immunoreactivity (NPY-LI).
Negative_regulation (reductions) of immunoreactivity in anterior associated with gaba, neuropeptide, somatostatin and substance p
7) Confidence 0.01 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1689475 Disease Relevance 0.19 Pain Relevance 0.42
Tramadol and its enantiomers differentially suppress c-fos-like immunoreactivity in rat brain and spinal cord following acute noxious stimulus.
Negative_regulation (suppress) of immunoreactivity in spinal cord associated with tramadol and spinal cord
8) Confidence 0.01 Published 1998 Journal Eur J Pain Section Title Doc Link 15102381 Disease Relevance 0 Pain Relevance 1.29
We examined the ability of tramadol, its enantiomers, and morphine as reference to suppress c-fos-like immunoreactivity (c-fos-ir) in rat spinal cord and brain regions following a noxious stimulus (i.p. administration of 3.5% acetic acid). c-fos-ir was measured by immunocytochemistry and the stained cells in each region were counted 2 h after the acetic-acid injection (2:25 h after tramadol or morphine).
Negative_regulation (suppress) of immunoreactivity in spinal cord associated with tramadol, spinal cord and morphine
9) Confidence 0.01 Published 1998 Journal Eur J Pain Section Abstract Doc Link 15102381 Disease Relevance 0 Pain Relevance 1.38
A single injection (25 to 75 mg/kg, ip) or repeated injections (2.5 to 10 mg/kg/day for 10 days, ip) of chlordecone caused a time- and dose-related decrease in pituitary [Met5]-enkephalin-like immunoreactivity (ME-LI) in adult rats.
Negative_regulation (decrease) of immunoreactivity in pituitary associated with enkephalin
10) Confidence 0.01 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6204421 Disease Relevance 0 Pain Relevance 0.27
Chronic prenatal exposure to carbon monoxide results in a reduction in tyrosine hydroxylase-immunoreactivity and an increase in choline acetyltransferase-immunoreactivity in the fetal medulla: implications for Sudden Infant Death Syndrome.
Negative_regulation (reduction) of hydroxylase-immunoreactivity in medulla associated with medulla and sudden infant death syndrome
11) Confidence 0.01 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 10744060 Disease Relevance 0.43 Pain Relevance 0.15
Using immunohistochemistry and quantitative image analysis, examination of the medulla of CO-exposed fetuses revealed a significant decrease in tyrosine hydroxylase-immunoreactivity (TH-IR) in the nucleus tractus solitarius, dorsal motor nucleus of the vagus (DMV), area postrema, intermediate reticular nucleus, and the ventrolateral medulla (VLM), and a significant increase in choline acetyltransferase-immunoreactivity (ChAT-IR) in the DMV and hypoglossal nucleus compared with controls.
Negative_regulation (decrease) of hydroxylase-immunoreactivity in medulla associated with medulla and toxocariasis
12) Confidence 0.01 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10744060 Disease Relevance 0.40 Pain Relevance 0.28
Overall, bromocriptine treatment resulted in a significant decline in CRF-like immunoreactivity (CRF-ir).
Negative_regulation (decline) of immunoreactivity
13) Confidence 0.00 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2901903 Disease Relevance 0 Pain Relevance 0.36
Morphine given centrally (i.c.v.) or peripherally (i.v.) caused a marked dose-related reduction in Fos-like immunoreactivity (Fos-LI) in laminae I-II at the middle portions of subnucleus caudalis (mid-Vc) and at the subnucleus caudalis/upper cervical spinal cord (Vc/C2) transition.
Negative_regulation (reduction) of immunoreactivity in spinal cord associated with spinal cord and morphine
14) Confidence 0.00 Published 2000 Journal Pain Section Abstract Doc Link 10692604 Disease Relevance 0.51 Pain Relevance 1.07
Stimulation of the perforant path elicits a behavioral response, wet dog shakes (WDS), and reduction in hippocampal dynorphin A(1-8) immunoreactivity (DYN-IR) and prodynorphin mRNA (DYN mRNA) in rats.
Negative_regulation (reduction) of immunoreactivity associated with dynorphin
15) Confidence 0.00 Published 1991 Journal Brain Res. Section Abstract Doc Link 1685342 Disease Relevance 0 Pain Relevance 0.37
Three weeks after a 6-OHDA lesion, dynorphin A(1-8)-like immunoreactivity (DN-LI) and the level of mRNA encoding prodynorphin in the striatum on the lesioned side were decreased compared with the contralateral control side.
Negative_regulation (decreased) of immunoreactivity in striatum associated with dynorphin
16) Confidence 0.00 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1977070 Disease Relevance 0.06 Pain Relevance 0.53
Numerous fibres displayed immunoreactivity for dynorphin (DYN), enkephalin (ENK), gamma-aminobutyric acid (GABA), nitric oxide synthase (NOS), substance P (SP) and vasoactive intestinal peptide (VIP), but, in contrast to other gut regions, fibres showing immunoreactivity for gastrin-releasing peptide, galanin and neuropeptide Y were rare in the taenia.
Negative_regulation (displayed) of immunoreactivity in gut associated with gaba, dynorphin, neuropeptide, enkephalin and substance p
17) Confidence 0.00 Published 1992 Journal Cell Tissue Res. Section Abstract Doc Link 1384981 Disease Relevance 0 Pain Relevance 0.64
A 5-min foot-shock instigated a significant depression in the levels of beta-endorphin immunoreactivity (beta-EI) in both the hypothalamus and periventricular beta-endorphinergic fibre-containing tissue.
Negative_regulation (depression) of immunoreactivity in hypothalamus associated with depression and shock
18) Confidence 0.00 Published 1981 Journal Brain Res. Section Abstract Doc Link 6260287 Disease Relevance 0.60 Pain Relevance 0.41

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