INT90114

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 4
Speculated 7
Reported most in Abstract
Documents 18
Total Number 25
Disease Relevance 6.38
Pain Relevance 10.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
nucleus 6
neuronal 6
spinal 5
spinal cord 4
neurons 3
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 29 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 20 100.00 Very High Very High Very High
Clonidine 8 100.00 Very High Very High Very High
cva 8 100.00 Very High Very High Very High
intrathecal 7 100.00 Very High Very High Very High
Locus ceruleus 3 100.00 Very High Very High Very High
Pain 23 99.98 Very High Very High Very High
Analgesic 12 99.98 Very High Very High Very High
Spinal cord 23 99.84 Very High Very High Very High
spinal dorsal horn 7 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 24 100.00 Very High Very High Very High
Cv General 3 Under Development 7 100.00 Very High Very High Very High
Ganglion Cysts 6 99.76 Very High Very High Very High
Injury 19 99.72 Very High Very High Very High
Substance Withdrawal Syndrome 1 99.72 Very High Very High Very High
Depression 4 99.16 Very High Very High Very High
Pain 16 98.82 Very High Very High Very High
Cough 72 98.16 Very High Very High Very High
Hyperalgesia 24 97.68 Very High Very High Very High
Diabetes Mellitus 11 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined the effect of application of the alpha2-adrenoceptor agonist, clonidine hydrochloride, on nNOS expression in the rat jejunal myenteric plexus after splanchinic ganglionectomy.
Spec (examined) Regulation (effect) of Gene_expression (expression) of nNOS associated with ganglionectomy, agonist and clonidine
1) Confidence 0.62 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591128 Disease Relevance 0 Pain Relevance 0.68
AIM: To investigate the effects of different muscarinic receptor (M) subtypes in the spinal cord on the scores of naloxone-precipitated morphine-withdrawal symptoms and the changes of nNOS expression in locus coeruleus (LC).
Regulation (changes) of Gene_expression (expression) of nNOS in spinal cord associated with locus ceruleus, narcan, withdrawal, morphine and spinal cord
2) Confidence 0.62 Published 2002 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 12147190 Disease Relevance 0.10 Pain Relevance 0.49
To elucidate how glucocorticoids affect this mechanism, we studied the effects of intrathecal (it) injection of prednisolone acetate (PA) on a nociceptive stimulus and the changes of nNOS and NR2B subunit expression in the spinal dorsal horn of Sprague Dawley rats following chronic compression of the dorsal root ganglia (CCD).
Regulation (changes) of Gene_expression (expression) of nNOS in spinal associated with nociception, spinal dorsal horn and intrathecal
3) Confidence 0.61 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.34 Pain Relevance 0.68
However, rosuvastatin had no influence on nNOS mRNA and protein expression.
Neg (no) Regulation (influence) of Gene_expression (expression) of nNOS
4) Confidence 0.55 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513366 Disease Relevance 0.67 Pain Relevance 0.45
This study was conducted to investigate the effect of 5-HT(1B/1D) receptor activation on nitroglycerin (NTG)-induced cerebral hyperaemia and neuronal nitric oxide synthase (nNOS) expression in trigeminovascular neurones.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of neuronal nitric oxide synthase in neuronal associated with cva and neuronal nitric oxide synthase
5) Confidence 0.53 Published 2003 Journal Cephalalgia Section Abstract Doc Link 14510930 Disease Relevance 0.16 Pain Relevance 0.46
Effects of intrathecal injection of prednisolone acetate on expression of NR2B subunit and nNOS in spinal cord of rats after chronic compression of dorsal root ganglia.
Regulation (Effects) of Gene_expression (expression) of nNOS in spinal cord associated with spinal cord and intrathecal
6) Confidence 0.45 Published 2007 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 18000292 Disease Relevance 0.31 Pain Relevance 0.70
This study was conducted to investigate the effect of 5-HT(1B/1D) receptor activation on nitroglycerin (NTG)-induced cerebral hyperaemia and neuronal nitric oxide synthase (nNOS) expression in trigeminovascular neurones.
Spec (investigate) Regulation (effect) of Gene_expression (expression) of nNOS in neuronal associated with cva and neuronal nitric oxide synthase
7) Confidence 0.45 Published 2003 Journal Cephalalgia Section Abstract Doc Link 14510930 Disease Relevance 0.16 Pain Relevance 0.46
We conducted a study of whether treatment with glial cell line-derived neurotrophic factor (GDNF) initiated at 2 or 4 weeks after spinal-root avulsion could promote survival and regulate neuronal nitric oxide synthase (nNOS) expression in adult rat spinal motoneurons.
Regulation (regulate) of Gene_expression (expression) of nNOS in glial cell associated with neuronal nitric oxide synthase
8) Confidence 0.44 Published 2006 Journal J. Neurotrauma Section Abstract Doc Link 16774476 Disease Relevance 0.20 Pain Relevance 0.05
The expression of the nNOS gene in the SON did not change in the untreated, saline- and formalin-injected rats.
Neg (not) Regulation (change) of Gene_expression (expression) of nNOS gene in SON
9) Confidence 0.44 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.31 Pain Relevance 0.04
OBJECTIVE: To determine the effect of the 5-HT2A receptor in control of spinal nociception, cerebral circulation, and nitric oxide synthase (nNOS) expression in trigeminovascular neurons.
Regulation (control) of in spinal Gene_expression (expression) of nNOS in neurons associated with nociception
10) Confidence 0.42 Published 2002 Journal Headache Section Abstract Doc Link 12482207 Disease Relevance 0.17 Pain Relevance 0.07
In this paper, we attempted to investigate whether the transcription factors regulating the gene expression of c-fos and nNOS, including activator protein-1 (AP-1), nuclear factor kappa B (NF-kappa B), and octamer factors (Oct), are activated by CFA during the development of hyperalgesia.
Spec (whether) Regulation (regulating) of Gene_expression (expression) of nNOS associated with hyperalgesia and freund adjuvant
11) Confidence 0.41 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.26 Pain Relevance 0.56
Unlike that observed for iNOS, acetaminophen did not appear to affect the regulation of nNOS or eNOS expression (Figure 5B) suggesting perhaps that the normalization of Akt S-nitrosylation by acetaminophen may be dependent on the reduced expression of iNOS.
Regulation (regulation) of Gene_expression (expression) of nNOS associated with paracetamol
12) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.20 Pain Relevance 0.50
The expressions of nNOS and TTX-R Na channels were not changed with LY treatment.
Neg (not) Regulation (changed) of Gene_expression (expressions) of nNOS
13) Confidence 0.37 Published 2003 Journal Diabetes Section Abstract Doc Link 12882929 Disease Relevance 1.42 Pain Relevance 0.67
Neither COX-2 nor iNOS mRNAs were observed in the mucosa before and 1 hr after acidification, while the gene expression of COX-1 and nNOS was constitutively detected in the mucosa and appeared to be slightly up-regulated after the acid stimulation.
Regulation (appeared) of Gene_expression (expression) of nNOS
14) Confidence 0.34 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12353866 Disease Relevance 0 Pain Relevance 0.09
Nevertheless, given that nNOS expression was not assessed in the central terminals of cough receptors we cannot conclude definitively that NOS is not a neurotransmitter of cough receptors.
Regulation (given) of Gene_expression (expression) of nNOS associated with neurotransmitter and cough
15) Confidence 0.32 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.53 Pain Relevance 0.38
We examined the effects of nociceptive stimulation on the expression levels of neuronal nitric oxide synthase (nNOS) mRNA, heteronuclear (hn)RNA for AVP and AVP mRNA in the rat paraventricular nucleus (PVN) and supraoptic nucleus (SON), using in situ hybridization histochemistry.
Spec (examined) Regulation (effects) of Gene_expression (expression) of nNOS in nucleus associated with nociception and neuronal nitric oxide synthase
16) Confidence 0.26 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474546 Disease Relevance 0.35 Pain Relevance 0.05
Accordingly, the aim of the present experiments was to examine the effects of probenecid administration on the nitroglycerin-induced expressions of nNOS, CamKIIalpha and CGRP in the rat caudal trigeminal nucleus.
Spec (examine) Regulation (effects) of Gene_expression (expressions) of nNOS in nucleus associated with calcitonin gene-related peptide
17) Confidence 0.26 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19744475 Disease Relevance 0.10 Pain Relevance 0.42
If DRG neurons lack sGC and the capacity to mobilize the NO/sGC/cGMP pathway, it is likely that S-nitrosylation is the only mechanism by which NO activates KATP channels in these cells. nNOS expression in DRG neurons is markedly up-regulated after injury, especially in the small and medium sized neuronal population, enabling these neurons to produce endogenous NO [50,51].
Regulation (regulated) of Gene_expression (expression) of nNOS in neurons associated with injury
18) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.10 Pain Relevance 0.03
Recent studies have demonstrated that EA stimulation of hindlimb acupoints induces an up-regulation of neuronal nitric oxide synthase (nNOS)/NADPH diaphorase (NADPHd) expression in the gracile nucleus.
Regulation (regulation) of Gene_expression (expression) of nNOS in gracile nucleus associated with electroacupuncture and neuronal nitric oxide synthase
19) Confidence 0.25 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442119 Disease Relevance 0.09 Pain Relevance 1.52
[Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain].
Regulation (Effect) of Gene_expression (expression) of nNOS in spinal associated with pain, analgesic, spinal dorsal horn and intrathecal
20) Confidence 0.24 Published 2006 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 17062944 Disease Relevance 0.10 Pain Relevance 0.83

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