INT90117

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Jun, Nos1) cytosol (Jun, Nos1) nucleus (Jun, Nos1)
mitochondrion (Nos1) enzyme binding (Nos1) DNA binding (Jun)
Jun (Rattus norvegicus)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.20 Very High Very High Very High
Freund adjuvant 8 97.36 Very High Very High Very High
Spinal cord 1 74.52 Quite High
Neuronal nitric oxide synthase 1 53.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, we conclude that AP-1, NF-kappa B and Oct are crucial for the expression of c-Fos proteins at an early stage (at 3 h) and for the expression of nNOS at a late stage of hyperalgesia (48 h post-injection) induced by CFA.
AP-1 Regulation (crucial) of Gene_expression (expression) of nNOS associated with hyperalgesia and freund adjuvant
1) Confidence 0.21 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.39 Pain Relevance 0.76

General Comments

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