INT90145

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1, OPRM1) signal transducer activity (OPRL1, OPRM1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1)
OPRL1 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 5 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
agonist 4 99.16 Very High Very High Very High
Enkephalin 1 96.08 Very High Very High Very High
antagonist 1 88.04 High High
qutenza 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 81.12 Quite High
Cough 1 75.00 Quite High
Neuroblastoma 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both mu-opioid and ORL1 receptor responses. beta-Funaltrexamine (beta-FNA) pretreatment also blocked both mu-opioid and ORL1 receptor responses, but only mu-opioid receptor binding was reduced.
ORL1 receptor Binding (binding) of mu-opioid receptor associated with orphanin, agonist, enkephalin, opioid receptor and opioid
1) Confidence 0.27 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.80
These compounds exhibit high affinity for the nociceptin receptor, moderate to excellent selectivity over the opioid mu receptor, and behave as full agonists.
nociceptin receptor Binding (affinity) of opioid mu receptor associated with orphanin, agonist and opioid
2) Confidence 0.21 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19339177 Disease Relevance 0.23 Pain Relevance 0.28

General Comments

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