INT90202

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Context Info
Confidence 0.94
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.47
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
ECM 2
myocytes 1
cartilage 1
brain 1
sclera 1
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 204 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 99.96 Very High Very High Very High
ischemia 27 99.68 Very High Very High Very High
COX-2 inhibitor 1 99.68 Very High Very High Very High
Snapping jaw 3 98.72 Very High Very High Very High
cva 18 95.60 Very High Very High Very High
Inflammation 70 95.36 Very High Very High Very High
Potency 3 95.28 Very High Very High Very High
aspirin 6 93.52 High High
Chronic pancreatitis 4 93.28 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 21 99.68 Very High Very High Very High
Diabetes Mellitus 5 99.40 Very High Very High Very High
Temporomandibular Joint Syndrome 2 98.72 Very High Very High Very High
Death 20 97.96 Very High Very High Very High
Rupture 6 97.88 Very High Very High Very High
Atherosclerosis 14 97.44 Very High Very High Very High
Pressure And Volume Under Development 3 96.88 Very High Very High Very High
Reperfusion Injury 3 96.76 Very High Very High Very High
Apoptosis 11 96.52 Very High Very High Very High
Cancer 39 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, this COX-2 inhibitor attenuated the degrading activity of MMP-2 as demonstrated by gelatin zymography.
Protein_catabolism (degrading) of MMP-2 associated with cox-2 inhibitor
1) Confidence 0.94 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.40 Pain Relevance 0.29
Dental amalgam conditioned buffer also inhibited the degradation of denatured type I collagen by purified MMP-2 on liquid phase assays.
Protein_catabolism (degradation) of MMP-2
2) Confidence 0.86 Published 2001 Journal Biomaterials Section Abstract Doc Link 11426881 Disease Relevance 0.20 Pain Relevance 0.21
Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process.
Protein_catabolism (degradation) of gelatinase B associated with diabetes mellitus
3) Confidence 0.82 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.49 Pain Relevance 0.46
Each group was compared with normal lung tissue with respect to tissue collagen and collagen degradation product content (hydroxyproline assay), gelatinolytic activity (zymography) and the expression of matrix metalloproteinases, MMP-2 and MMP-9 (Western immunoblot).
Protein_catabolism (degradation) of MMP-2 in lung associated with metalloproteinase
4) Confidence 0.73 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.65 Pain Relevance 0.38
During form deprivation in mammals (tree shrews and primates), the sclera weakens due to increased degradation and reduced synthesis of extracellular matrices (ECM) and collagens, and an increased synthesis of matrix metalloproteinase and gelatinase A in the sclera [20,21].
Protein_catabolism (degradation) of gelatinase A in sclera associated with metalloproteinase
5) Confidence 0.64 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994335 Disease Relevance 0.41 Pain Relevance 0.08
Our data suggest that MMP-2 plays an important role in fibrocartilage degradation in internal derangement of the temporomandibular joint.
Protein_catabolism (degradation) of MMP-2 in internal associated with snapping jaw and metalloproteinase
6) Confidence 0.57 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 10947247 Disease Relevance 0.53 Pain Relevance 0.53
The matrix-metalloprotease enzymes (MMP's 1,3,8) express collagenase type 2 activity which can degrade cartilage matrix (6).
Protein_catabolism (degrade) of collagenase type 2 in cartilage
7) Confidence 0.55 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529383 Disease Relevance 0.47 Pain Relevance 0.20
Recombinant human MMP-2 cleaved calcitonin gene-related peptide (CGRP) specifically at the Gly(14)-Leu(15) peptide bond and reduced the vasodilatory potency of CGRP by 20-fold.
Protein_catabolism (cleaved) of MMP-2 associated with metalloproteinase, potency and calcitonin gene-related peptide
8) Confidence 0.50 Published 2000 Journal Circ. Res. Section Abstract Doc Link 11029402 Disease Relevance 0.13 Pain Relevance 1.07
In this way, the propeptide of the pro-mmp-2 present in this ternary complex formed on the cell surface is cleaved by an adjacent active mt1-mmp.
Protein_catabolism (cleaved) of mmp-2
9) Confidence 0.48 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.06 Pain Relevance 0
There are many types of MMPs, the most known are MMP-2, a gelatinase capably to degrade type IV collagen, represented in the subendothelial basement membrane.
Protein_catabolism (degrade) of MMP-2 in basement membrane associated with metalloproteinase
10) Confidence 0.45 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 0.63 Pain Relevance 0.22
In addition to a direct loss of vessel wall integrity, MMP-2 mediated degradation of ECM components may lead to loss of specific ECM-integrin interactions resulting in apoptotic vascular cell death [40].
Protein_catabolism (degradation) of MMP-2 in ECM associated with apoptosis and death
11) Confidence 0.43 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1557842 Disease Relevance 1.30 Pain Relevance 0.54
In addition, MMP-12 can activate other MMPs, for example, MMP-2 and -3, leading to subsequent degradation of other ECM proteins [10].
Protein_catabolism (degradation) of MMP-2 associated with metalloproteinase
12) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.80 Pain Relevance 0.84
Since MMP-2 and MMP-9 are believed to be largely responsible for the degradation of the blood brain barrier and also involved in the signaling of neuronal cell death [24,25], the inhibition of the proteolytic cascade is a logical target for several models of brain injury that involve matrix degradation and vascular instability [26].
Protein_catabolism (degradation) of MMP-2 in brain associated with brain injury and death
13) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.95 Pain Relevance 0.14
The peroxynitrite-mediated activation of matrix metalloproteinase-2 (MMP-2) and subsequent cleavage of troponin I (TnI) in ventricular myocytes is a detrimental effect of ischemia/reperfusion injury.
Protein_catabolism (cleavage) of metalloproteinase-2 in myocytes associated with reperfusion injury, ischemia and metalloproteinase
14) Confidence 0.09 Published 2006 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16530785 Disease Relevance 0.19 Pain Relevance 0.37
Several factors affect degradability of collagen, for example, structure contraction caused by cell penetration, collagenase, gelatinase and other non-specific proteinases can digest collagen [50].
Protein_catabolism (degradability) of gelatinase
15) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956096 Disease Relevance 0.26 Pain Relevance 0.09

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