INT90213

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Context Info
Confidence 0.05
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 6.28
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mvk) mRNA binding (Mvk) peroxisome (Mvk)
cytoplasm (Mvk)
Mvk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Crohn's disease 1 94.96 High High
Arthritis 3 92.56 High High
abdominal pain 3 90.72 High High
headache 2 89.68 High High
Inflammation 7 25.00 Low Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 11 100.00 Very High Very High Very High
Cancer 1 99.88 Very High Very High Very High
Fever 35 99.68 Very High Very High Very High
Necrosis 1 99.64 Very High Very High Very High
Syndrome 11 97.60 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 2 97.20 Very High Very High Very High
Ulcers 2 95.48 Very High Very High Very High
Disease 4 94.64 High High
Lymphadenopathy 2 93.52 High High
Arthritis 3 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This new concept includes a broad number of disorders, but the spotlight has been focused for the past two years on periodic fevers (familial Mediterranean fever [FMF]; mevalonate kinase deficiency [MVK]; tumor necrosis factor [TNF] receptor-associated periodic syndrome [TRAPS]; cryopyrin-associated periodic syndrome [CAPS]), Crohn's disease and Blau syndrome, thanks to the recent understanding of their molecular basis.
Negative_regulation (deficiency) of MVK associated with mevalonate kinase deficiency, crohn's disease, syndrome, disease, fever, necrosis, cancer and tumor necrosis factor receptor-associated periodic syndrome
1) Confidence 0.05 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.47 Pain Relevance 0.15
Mevalonate kinase deficiency and Dutch type periodic fever.
Negative_regulation (deficiency) of Mevalonate kinase associated with mevalonate kinase deficiency and fever
2) Confidence 0.03 Published 2000 Journal Clin. Exp. Rheumatol. Section Title Doc Link 10949735 Disease Relevance 2.32 Pain Relevance 0.21
DPF is caused by a deficiency of the enzyme mevalonate kinase (MK).
Negative_regulation (deficiency) of mevalonate kinase associated with fever
3) Confidence 0.03 Published 2000 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 10949735 Disease Relevance 2.49 Pain Relevance 0.23

General Comments

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