INT90219

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Context Info
Confidence 0.20
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.47
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Lgals1) cytoplasm (Lgals1) signal transducer activity (Lgals1)
extracellular space (Lgals1) signal transduction (Lgals1) extracellular region (Lgals1)
Anatomy Link Frequency
leukocytes 1
stem cells 1
Lgals1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 50 100.00 Very High Very High Very High
Arthritis 108 98.40 Very High Very High Very High
Chronic pancreatitis 11 97.88 Very High Very High Very High
lidocaine 102 93.40 High High
rheumatoid arthritis 54 87.84 High High
fibrosis 4 75.60 Quite High
Inflammation 170 68.32 Quite High
cINOD 3 63.76 Quite High
cytokine 71 60.48 Quite High
chemokine 20 53.28 Quite High
Disease Link Frequency Relevance Heat
Arthritis 112 98.40 Very High Very High Very High
Pancreatitis 14 97.88 Very High Very High Very High
Cancer 38 90.40 High High
Rheumatoid Arthritis 54 87.84 High High
Cramps 11 86.76 High High
Apoptosis 36 85.76 High High
Pressure And Volume Under Development 6 78.68 Quite High
Colon Cancer 5 77.68 Quite High
Carcinoma 2 76.00 Quite High
Fibrosis 3 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies have shown that mesenchymal stem cells are inherently immunosuppressive through production of PGE-2, interleukin-10 and expression of the tryptophan catabolizing enzyme indoleamine 2,3,-dioxygenase as well as Galectin-1 [125,126].
Gene_expression (expression) of Galectin-1 in stem cells
1) Confidence 0.20 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 0.13 Pain Relevance 0
Through matrix-assisted laser desorption ionization time of flight mass spectrometry and then NCBInr and SWISS-PROT databases searching, 12 protein spots were finally identified including galectin-1, annexin A1, annexin IV, transcription factor BTF3A, calreticulin.
Gene_expression (identified) of galectin-1
2) Confidence 0.19 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 16584632 Disease Relevance 0.83 Pain Relevance 0.06
In addition, Galectin-1 prolongs exposure of phosphatidylserine on the surface of leukocytes, suggesting a role in promoting PMN clearance [24].
Gene_expression (prolongs) of Galectin-1 in leukocytes
3) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.43 Pain Relevance 0.66
Immunohistochemistry showed a distribution pattern of galectin-1 and galectin-3 similar to that described for in situ hybridization.
Gene_expression (pattern) of galectin-1
4) Confidence 0.13 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 10950114 Disease Relevance 0.88 Pain Relevance 0.75
We hypothesized, that the HIP/PAP (the lactose-binding protein) should bind minimally modified 18F-labeled lactose analogues with high affinity, and that this “receptor-ligand” type of an imaging approach should allow for visualization of peritumoral infiltrated pancreatic tissue that 130-fold over-expresses the HIP/PAP protein, as compared to normal pancreatic tissue.
Gene_expression (expresses) of lactose-binding protein associated with imagery
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776527 Disease Relevance 0.40 Pain Relevance 0.18
Other molecules that have been demonstrated to play a role in arthritis using gene transfer in various in vitro or animal models are Csk, cathepsin L, fibronectin, galectin-1, p16INK4A, p21Cip1, SOCS3, soluble CR1, superoxide dismutase and catalase, Ras, and prothymosin ?
Gene_expression (fibronectin) of galectin-1 associated with arthritis
6) Confidence 0.01 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 0.78 Pain Relevance 0.29

General Comments

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