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Context Info
Confidence 0.03
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 1.31

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oxidoreductase activity (CYP2D6, Cyp1a2) endoplasmic reticulum (CYP2D6, Cyp1a2) mitochondrion (CYP2D6)
small molecule metabolic process (CYP2D6) enzyme binding (Cyp1a2) response to stress (Cyp1a2)
CYP2D6 (Homo sapiens)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 8 100.00 Very High Very High Very High
fluoxetine 6 100.00 Very High Very High Very High
sSRI 1 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that cytochrome P450IID6 (CYP2D6), an enzyme that is strongly inhibited by FLX, preferentially metabolizes (R)-MTD, whereas CYP1A2, which is strongly inhibited by FLV, metabolizes both enantiomers.
CYP2D6 Binding (metabolizes) of CYP1A2 associated with methadone and fluoxetine
1) Confidence 0.03 Published 1997 Journal J Clin Psychopharmacol Section Abstract Doc Link 10950475 Disease Relevance 0.09 Pain Relevance 1.31

General Comments

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