INT90226

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Context Info
Confidence 0.65
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.94
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk9) mitochondrion (Mapk9) nucleus (Mapk9)
transcription factor binding (Mapk9) cytoplasm (Mapk9)
Anatomy Link Frequency
microglial cells 1
Mapk9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 13 98.40 Very High Very High Very High
Inflammation 4 97.84 Very High Very High Very High
Glutamate receptor 3 87.44 High High
anesthesia 1 85.64 High High
tetrodotoxin 3 80.48 Quite High
tolerance 3 80.36 Quite High
cytokine 4 71.68 Quite High
Central nervous system 13 64.24 Quite High
adenocard 12 59.56 Quite High
Neurotransmitter 12 49.56 Quite Low
Disease Link Frequency Relevance Heat
Stress 5 99.44 Very High Very High Very High
Hemorrhage 13 98.40 Very High Very High Very High
INFLAMMATION 5 97.84 Very High Very High Very High
Sepsis 1 68.96 Quite High
Apoptosis 4 65.20 Quite High
Neurological Disease 1 62.72 Quite High
Epilepsy 4 60.88 Quite High
Hypoxia 7 54.56 Quite High
Cv Unclassified Under Development 8 38.84 Quite Low
Brain Injury 1 21.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of p44/42 and SAPK/JNK was detected in all tissues following both sham and SLH, and this effect was significantly more pronounced following SLH (P < 0.05).
Gene_expression (detected) of SAPK associated with cva
1) Confidence 0.65 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 1.04 Pain Relevance 0.74
[133], the stress-activated protein kinases (SAPK)/JNK pathway [134], and the production of 2-arachidonoylglycerol, which is also involved in inflammation induction by microglial cells.
Gene_expression (production) of SAPK in microglial cells associated with stress and inflammation
2) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.72 Pain Relevance 0.26
Low basal expression of JNK-2 (SAPK-alpha) and JNK-3 (SAPK-beta) was seen in vivo and in vitro.
Gene_expression (expression) of SAPK-alpha
3) Confidence 0.06 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10950813 Disease Relevance 0.17 Pain Relevance 0.34

General Comments

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