INT90228

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.14
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
feces 1
liver 1
urine 1
CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 4 98.96 Very High Very High Very High
Calcium channel 10 79.84 Quite High
tolerance 10 61.84 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 98.78 Very High Very High Very High
Pulmonary Hypertension 154 88.84 High High
Pressure Volume 2 Under Development 4 81.64 Quite High
Increased Venous Pressure Under Development 16 77.28 Quite High
Apoptosis 2 32.92 Quite Low
Reprotox - General 2 30 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Thrombosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the predicted rates combined with published rates for in vivo CYP3A degradation, our model predicts that fluoxetine, clarithromycin, and the primary metabolite of diltiazem reduce the steady-state concentration of liver CYP3A4 to approximately 72, 39, or 21% of initial levels, respectively.
Protein_catabolism (degradation) of CYP3A in liver associated with fluoxetine
1) Confidence 0.22 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10950845 Disease Relevance 0 Pain Relevance 0.32
Tadalafil is predominantly metabolized by the liver by CYP3A and eliminated primarily in the feces and urine.50,51 Unlike sildenafil, it is recommended that patients with mild-to-moderate renal or hepatic dysfunction undergo a dose adjustment to 20 mg daily.31 As tadalafil is metabolized by CYP3A, inhibitors of the enzyme such as clarithromycin may lead to elevated serum concentrations.50 Combined usage of bosentan and tadalafil has been shown to lead to a 41.5% decrease in the serum levels of tadalafil with no effect on bosentan.52 Similar effects of combined use of tadalafil and ambrisentan have not been observed.53

PDE-5 inhibition for the treatment of PAH

Protein_catabolism (metabolized) of CYP3A in urine associated with pulmonary hypertension and hepatotoxicity
2) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868348 Disease Relevance 0.57 Pain Relevance 0.07
Tadalafil is predominantly metabolized by the liver by CYP3A and eliminated primarily in the feces and urine.50,51 Unlike sildenafil, it is recommended that patients with mild-to-moderate renal or hepatic dysfunction undergo a dose adjustment to 20 mg daily.31 As tadalafil is metabolized by CYP3A, inhibitors of the enzyme such as clarithromycin may lead to elevated serum concentrations.50 Combined usage of bosentan and tadalafil has been shown to lead to a 41.5% decrease in the serum levels of tadalafil with no effect on bosentan.52 Similar effects of combined use of tadalafil and ambrisentan have not been observed.53

PDE-5 inhibition for the treatment of PAH

Protein_catabolism (metabolized) of CYP3A in feces associated with pulmonary hypertension and hepatotoxicity
3) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868348 Disease Relevance 0.57 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox