INT90240

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 10.00
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYOG) nucleus (MYOG) DNA binding (MYOG)
Anatomy Link Frequency
muscle cell 3
smooth muscle 3
skeletal muscle 3
satellite cells 2
muscle 2
MYOG (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 94.40 High High
Inflammation 71 91.84 High High
dexamethasone 10 87.52 High High
tetrodotoxin 2 82.12 Quite High
Pain 8 75.28 Quite High
imagery 73 73.92 Quite High
cytokine 26 38.68 Quite Low
vincristine 4 37.44 Quite Low
addiction 1 25.00 Low Low
positron emission tomography 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 141 100.00 Very High Very High Very High
Rhabdomyosarcoma 18 100.00 Very High Very High Very High
Cancer 93 99.84 Very High Very High Very High
Neuroblastoma 3 99.16 Very High Very High Very High
Muscular Dystrophy 72 98.56 Very High Very High Very High
Recurrence 12 98.32 Very High Very High Very High
Primitive Neuroectodermal Tumors 54 96.72 Very High Very High Very High
Diarrhoea 2 94.96 High High
Abdominal Pain 2 94.40 High High
Hot Flashes 2 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], alpha-smooth muscle actin 1/3 [focal], calponin [1/3], caldesmon [0/3], and myogenin [0/3]).
Gene_expression (expression) of myogenin in skeletal muscle
1) Confidence 0.75 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.37 Pain Relevance 0.33
Desmin, actin, Myf4, and MyoD1 were positive in tumor cells, and a diagnosis of rhabdomyosarcoma was eventually made.
Gene_expression (positive) of Myf4 associated with cancer and rhabdomyosarcoma
2) Confidence 0.74 Published 2007 Journal Pathol. Res. Pract. Section Abstract Doc Link 17905523 Disease Relevance 1.49 Pain Relevance 0.07
RT-PCR analysis revealed the expression of M-cadherin, Myf-5, Myogenin, Pax7, MyoD and MRF4 in normal and DMD CD133+CXCR4+CD34- cells after 7 days of co-culture.
Gene_expression (expression) of Myogenin associated with muscular dystrophy
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.25 Pain Relevance 0
In general, studies that have compared the expression of MRFs such as myogenic determination factor (myoD), myogenic regulatory factor 5, and myogenin in rats have found that expression of these factors is decreased in older compared to younger skeletal muscle [51].
Gene_expression (expression) of myogenin in skeletal muscle
4) Confidence 0.29 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.12 Pain Relevance 0
Another factor in the behavior of muscle satellite cells is myostatin, which is thought to suppress differentiation and proliferation of myocytes by suppressing the expression of MRFs such as myoD and myogenin [53].
Gene_expression (expression) of myogenin in myocytes
5) Confidence 0.29 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.15 Pain Relevance 0
At day 7 and day 14 total RNA was extracted for RT-PCR in order to investigate the expression of MyoD and myogenin respectively.
Spec (investigate) Gene_expression (expression) of myogenin
6) Confidence 0.29 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0.07
Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], alpha-smooth muscle actin 1/3 [focal], calponin [1/3], caldesmon [0/3], and myogenin [0/3]).
Gene_expression (expression) of myogenin in smooth muscle
7) Confidence 0.26 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.37 Pain Relevance 0.33
In general, studies that have compared the expression of MRFs such as myogenic determination factor (myoD), myogenic regulatory factor 5, and myogenin in rats have found that expression of these factors is decreased in older compared to younger skeletal muscle [51].
Gene_expression (expression) of myogenin in skeletal muscle
8) Confidence 0.23 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.11 Pain Relevance 0
In addition, amniotic membrane-isolated cells underwent in vitro osteogenic (von Kossa stain), adipogenic (Oil Red-O stain), chondrogenic (collagen type II immunohistochemichal detection) and myogenic (RT-PCR MyoD and Myogenin expression as well as desmin immunohistochemical detection) differentiation.
Gene_expression (expression) of Myogenin
9) Confidence 0.22 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
The muscle-specific helix-loop-helix (HLH) transcription factors myoD, myogenin, MRF4, and myf-5 are called the muscle regulatory factor family (MRF).
Gene_expression (called) of myogenin in muscle
10) Confidence 0.18 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10951440 Disease Relevance 0.06 Pain Relevance 0.06
Kir2.1 channel activity, which is responsible for this hyperpolarization, initiates myogenesis by triggering the expression of early transcription factors such as myogenin and myocyte enhancer factor (MEF2) [27].
Gene_expression (expression) of myogenin in myocyte
11) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2581599 Disease Relevance 0.07 Pain Relevance 0.08
The neoplastic cells were negative for CD43, ALK, CD30, EMA, smooth muscle actin, cytokeratin, desmin, myogenin, TTF1, CD99, CD1a, LMP-1, CD117, HMB45, and Mart-1/Melan A.
Gene_expression (negative) of myogenin in smooth muscle
12) Confidence 0.15 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.53 Pain Relevance 0
Some cells were positive for desmin and myogenin (figure 2b, 2c).
Gene_expression (positive) of myogenin
13) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1361803 Disease Relevance 0.70 Pain Relevance 0
In Trichinella infection, expression of Akt, MyoD, myogenin and p21 was greatly increased during 13–28 dpi [6,24-26].
Gene_expression (expression) of myogenin associated with infection
14) Confidence 0.04 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.24 Pain Relevance 0
Secondly, IGF induces differentiation of myoblast via the phosphatidylinositol 3-kinase (PI3-K) pathway, which activates Akt and subsequently modulates expression of terminal muscle differentiation markers, such as p21, MyoD, myogenin and MEF2 [74,75,77].
Gene_expression (expression) of myogenin in muscle
15) Confidence 0.04 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.18 Pain Relevance 0
On the other hand, she was negative for cytokeratin, epithelial membrane antigen, desmin, Myo D-1, myogenin and smooth muscle actin.
Neg (negative) Gene_expression (negative) of myogenin in smooth muscle
16) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Abstract Doc Link PMC2848680 Disease Relevance 1.03 Pain Relevance 0
Myogenic regulatory factors (MyoD and myogenin) were over-expressed in infected muscle tissue of both T. spiralis and T. pseudospiralis infection, and the MyoD factor is highly expressed in the satellite cells of infected muscle cells [6].
Gene_expression (expressed) of myogenin in satellite cells associated with infection
17) Confidence 0.04 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.23 Pain Relevance 0
Myogenic regulatory factors (MyoD and myogenin) were over-expressed in infected muscle tissue of both T. spiralis and T. pseudospiralis infection, and the MyoD factor is highly expressed in the satellite cells of infected muscle cells [6].
Gene_expression (expressed) of myogenin in satellite cells associated with infection
18) Confidence 0.04 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.22 Pain Relevance 0
The invasion of new born larvae induces the de-differentiation of infected muscle cell, with features of loss of muscle cell characteristics, change in muscle gene expression and up-regulated expression of cell differentiation related genes (such as MyoD, myogenin, MEF2, Pbx1, Numb, Pax7, Msx and NFAT) in infected muscle tissues [7,9,98-100].
Gene_expression (expression) of myogenin in muscle cell
19) Confidence 0.03 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.40 Pain Relevance 0
On the other hand, her tests for CK, EMA, desmin, Myo D-1, Myogenin and SMA were negative.
Neg (negative) Gene_expression (negative) of Myogenin
20) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2848680 Disease Relevance 0.69 Pain Relevance 0

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