INT90242

Context Info Confidence 0.34 First Reported 2000 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.46 Pain Relevance 0.22

nucleoplasm (MYOG) nucleus (MYOG) DNA binding (MYOG)

Anatomy Link Frequency satellite cells 1 MYOG (Homo sapiens)

Pain Link Frequency Relevance Heat withdrawal 2 89.92 addiction 1 89.44 tetrodotoxin 1 85.20 Sciatic nerve 1 30.00 cytokine 5 5.00 lidocaine 2 5.00 Central nervous system 1 5.00 anesthesia 1 5.00 alcohol 1 5.00 Neuropeptide 1 5.00

Disease Link Frequency Relevance Heat Hypertrophy 11 99.92 Recurrence 10 98.32 Glycogen Storage Disease 1 90.28 Malignant Neoplastic Disease 3 89.16 Blastoma 36 87.44 Diabetes Mellitus 4 87.00 Glioma 1 85.28 Paralysis 1 83.20 Necrosis 1 79.20 Obesity 2 75.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This notion is strengthened by our observations that IL-6 protein is evident in 80% of satellite cells at T24 and less than 10% of satellite cells at T72 corresponding to increases in MRF4 and Myogenin (myogenic regulatory factors responsible for the initiation of differentiation) observed at T72 previously [39].

Positive_regulation (increases) of Myogenin in satellite cells

1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.12 Pain Relevance 0.09

Myogenin was upregulated in the 6-hour comparison, and this observation was validated in the published [8] rat RE study (Figure 4).

Positive_regulation (upregulated) of Myogenin

2) Confidence 0.19 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.55 Pain Relevance 0

These changes in the ubiquitously expressed HLH factors might have important functional implications for downstream gene expression, but in comparison, myogenin mRNA was increased 10-fold.

Positive_regulation (increased) of myogenin mRNA

3) Confidence 0.18 Published 2000 Journal Muscle Nerve Section Abstract Doc Link 10951440 Disease Relevance 0.08 Pain Relevance 0.13

Some cells were positive for desmin and myogenin (figure 2b, 2c).

Positive_regulation (positive) of myogenin

4) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1361803 Disease Relevance 0.70 Pain Relevance 0

General Comments

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