INT90272

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 18
Total Number 25
Disease Relevance 4.69
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Anatomy Link Frequency
myocardium 3
cerebellum 2
blood 1
NMJ 1
olfactory 1
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
depression 37 99.92 Very High Very High Very High
Dopamine 339 96.48 Very High Very High Very High
tolerance 82 94.80 High High
Eae 14 92.04 High High
Migraine 24 90.92 High High
long-term potentiation 34 90.08 High High
Dismenorea 4 88.92 High High
Calcium channel 3 83.04 Quite High
nMDA receptor 169 82.24 Quite High
ischemia 52 79.52 Quite High
Disease Link Frequency Relevance Heat
Depression 37 99.92 Very High Very High Very High
Drug Induced Neurotoxicity 4 96.72 Very High Very High Very High
Impaired Glucose Tolerance 80 95.44 Very High Very High Very High
Anxiety Disorder 42 93.68 High High
Disease 96 93.08 High High
Headache 13 90.92 High High
Migraine With Aura 10 89.36 High High
Dysmenorrhea 4 88.92 High High
Targeted Disruption 171 88.36 High High
Death 26 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PP2A is widely expressed in all cells of olfactory bulb, whereas TH is expressed only in periglomerular dopaminergic neurons, which make up less than 10% of all olfactory cells.
Gene_expression (expressed) of PP2A in olfactory
1) Confidence 0.68 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.07 Pain Relevance 0
As a negative control, we evaluated cerebellum from WT-Syn++ and Non-Tg mice in which immunoblots showed that TH and PP2A levels were identical, and human a-Syn was undetected (not shown).
Gene_expression (levels) of PP2A in cerebellum
2) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
To verify this by non-pharmacological means, we transiently overexpressed the wild type PP2A catalytic domain (PP2A-WT) (52) in MN9D cells and then measured TH-Ser(P)-19 in comparison to mock-transfected MN9D cells.
Gene_expression (overexpressed) of PP2A
3) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
To verify this by non-pharmacological means, we transiently overexpressed the wild type PP2A catalytic domain (PP2A-WT) (52) in MN9D cells and then measured TH-Ser(P)-19 in comparison to mock-transfected MN9D cells.
Gene_expression (overexpressed) of PP2A
4) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Overexpression of PP2A-WT did not alter total TH levels; however, TH-Ser(P)-19 levels were measurably reduced (Fig. 2C).
Gene_expression (Overexpression) of PP2A
5) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Immunoblots with equal protein loading had equivalent levels of TH and PP2A in A53T and control mice (not shown).
Gene_expression (levels) of PP2A
6) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Our findings in ASKO mice demonstrated that a loss of a-Syn produced the opposite effect on TH and PP2A imply that enzymatic dysregulation can also occur by a loss of soluble a-Syn, as those mice express normal levels of ?
Gene_expression (effect) of PP2A
7) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.12 Pain Relevance 0.06
We confirmed the absence of a-Syn in ASKO mice and noted equivalent total TH and PP2A levels in ASKO and Non-Tg controls on immunoblots with equal protein loading (not shown).
Gene_expression (levels) of PP2A
8) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.04
As previously mentioned, PP2A is the main TH phosphatase.
Gene_expression (mentioned) of PP2A
9) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
TH activity was not measurable in cerebellar homogenates, and PP2A activity in WT-Syn++ and Non-Tg cerebellum was not significantly different (WT-Syn++, 0.92 ± 0.07 pmol of PO4/min/?
Gene_expression (activity) of PP2A in cerebellum
10) Confidence 0.59 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Western blot analysis indicated the presence of PP1(alpha) and PP2A in immature and mature mice.
Gene_expression (presence) of PP2A
11) Confidence 0.59 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.22 Pain Relevance 0.22
To further explore the mechanism of action behind ADH and/or ethanol-induced response in AMPK activation, expression of protein phosphatase PP2A (both PP2AA and PP2AB) and PP2C was examined in FVB and ADH myocardium with or without acute ethanol challenge.
Spec (examined) Gene_expression (expression) of PP2AA in myocardium
12) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Neither acute ethanol exposure nor ADH affected the expression of PP2AB.
Gene_expression (expression) of PP2AB
13) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Our findings suggest that the phosphorylation of AMPK at Thr172 may be influenced by the expression of PP2A but less likely PP2C?
Gene_expression (expression) of PP2A
14) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.30 Pain Relevance 0.04
Interestingly, expression of PP2AA was significantly downregulated by acute ethanol exposure, the effect of which was intensified by ADH.
Gene_expression (expression) of PP2AA
15) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
To further explore the mechanism of action behind ADH and/or ethanol-induced response in AMPK activation, expression of protein phosphatase PP2A (both PP2AA and PP2AB) and PP2C was examined in FVB and ADH myocardium with or without acute ethanol challenge.
Spec (examined) Gene_expression (expression) of PP2AB in myocardium
16) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
The main findings from these simulations suggest that the presence of the PKA–PP2A–phosphoThr75 loop causes increased formation of free PKAc as well as phosphoThr34 if a dopamine input is paired with a transient calcium elevation.
Gene_expression (presence) of PP2A associated with dopamine
17) Confidence 0.43 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.07
In addition, ADH transgene itself did not affect the expression of PP2AA and PP2C?
Gene_expression (expression) of PP2AA
18) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
To further explore the mechanism of action behind ADH and/or ethanol-induced response in AMPK activation, expression of protein phosphatase PP2A (both PP2AA and PP2AB) and PP2C was examined in FVB and ADH myocardium with or without acute ethanol challenge.
Spec (examined) Gene_expression (expression) of PP2A in myocardium
19) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
To monitor the change in the AMPK degrading phosphatase, expression of protein phosphatase 2A (PP2A) and protein phosphatase 2C?
Gene_expression (expression) of PP2A
20) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.58 Pain Relevance 0.07

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