INT90276

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Context Info
Confidence 0.73
First Reported 2000
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 0.83
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Anatomy Link Frequency
myometrium 4
spinal cord 2
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 20 100.00 Very High Very High Very High
Spinal cord 36 99.68 Very High Very High Very High
Glutamate 93 99.36 Very High Very High Very High
long-term potentiation 24 97.32 Very High Very High Very High
Kinase C 15 95.42 Very High Very High Very High
agonist 4 95.28 Very High Very High Very High
Morphine 4 95.04 Very High Very High Very High
Dopamine 357 94.64 High High
sodium channel 111 94.40 High High
Potency 1 82.60 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 20 100.00 Very High Very High Very High
Apoptosis 3 56.48 Quite High
Nervous System Malformation 6 54.32 Quite High
Thyroid Disease 3 24.36 Low Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Convulsion 12 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, these studies have indicated 1) that PP1 is the primary myometrial OA-sensitive PP; 2) that inhibition of PP1 had no effect on spontaneous contractions, whereas it markedly inhibited OT-stimulated uterine contractions; and 3) that PP1 is differentially expressed in the circular and longitudinal myometrium in relation to sexual development.
Gene_expression (expressed) of PP1 in myometrium associated with dismenorea
1) Confidence 0.73 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.16 Pain Relevance 0.16
During the early prepubertal period PP1(alpha) was expressed in longitudinal myometrium and absent in circular myometrium; whereas, during the transition to sexual maturity PP1(alpha) was observed in both the longitudinal and circular myometrium.
Neg (absent) Gene_expression (expressed) of PP1 in myometrium
2) Confidence 0.73 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.08 Pain Relevance 0.15
In summary, these studies have indicated 1) that PP1 is the primary myometrial OA-sensitive PP; 2) that inhibition of PP1 had no effect on spontaneous contractions, whereas it markedly inhibited OT-stimulated uterine contractions; and 3) that PP1 is differentially expressed in the circular and longitudinal myometrium in relation to sexual development.
Gene_expression (expressed) of PP1 in myometrium associated with dismenorea
3) Confidence 0.64 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.17 Pain Relevance 0.17
Western blot analysis indicated the presence of PP1(alpha) and PP2A in immature and mature mice.
Gene_expression (presence) of PP1
4) Confidence 0.64 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.22 Pain Relevance 0.22
During the early prepubertal period PP1(alpha) was expressed in longitudinal myometrium and absent in circular myometrium; whereas, during the transition to sexual maturity PP1(alpha) was observed in both the longitudinal and circular myometrium.
Neg (absent) Gene_expression (absent) of PP1 in myometrium
5) Confidence 0.57 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.08 Pain Relevance 0.15
Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors.
Gene_expression (produced) of PP1 associated with glutamate and long-term potentiation
6) Confidence 0.31 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.74
CaMKII was included in the model as a buffer for CaM; therefore only three reactions are included: reversible binding of CaM to CaMKII; a slow autophosphorylation into CaMKIIp, in which CaM is trapped; and dephosphorylation of CaMKIIp by PP1.
Gene_expression (by) of PP1
7) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.12
The net effects of these different calcium inputs on the PKAc:PP1 balance are summarized in Figure S2B.
Gene_expression (balance) of PP1
8) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.03
Up-regulation of KEPI expression by morphine, an agonist at PKC-regulating G-protein-coupled mu receptors, provides a novel signaling paradigm in which the half-lives of serine/threonine phosphorylation events can be influenced by activities at G(i)/G(o)-coupled receptors that modulate KEPI expression, KEPI phosphorylation, and KEPI regulation of PP1 activity.
Gene_expression (expression) of PP1 associated with kinase c, agonist and morphine
9) Confidence 0.24 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11812771 Disease Relevance 0 Pain Relevance 0.57
Two serine/threonine phosphatases, PP2A and PP1, are both ubiquitously expressed in the zebrafish spinal cord at 48 hpf [17], a time when T4 rapidly regulates RB sodium current.
Gene_expression (expressed) of PP1 in spinal cord associated with spinal cord
10) Confidence 0.06 Published 2009 Journal Neural Dev Section Body Doc Link PMC2704202 Disease Relevance 0 Pain Relevance 0.12
In contrast, the IC50 for PP1 inhibition by OA is much higher (approximately 0.5 ?
Gene_expression (inhibition) of PP1
11) Confidence 0.05 Published 2009 Journal Neural Dev Section Body Doc Link PMC2704202 Disease Relevance 0 Pain Relevance 0.10
In the zebrafish embryo, MAPK (ERK1/2), MAPK (p38), and protein phosphatase (PP) subtypes PP1 and PP2A are all expressed in the spinal cord at 48 hours post-fertilization (hpf) [17], allowing for pharmacological assay of the effects of kinase and phosphatase inhibition on RB INa and embryonic T4 signaling.
Gene_expression (expressed) of PP1 in spinal cord associated with spinal cord
12) Confidence 0.05 Published 2009 Journal Neural Dev Section Body Doc Link PMC2704202 Disease Relevance 0.11 Pain Relevance 0.34

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