INT90277

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 4.04
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Anatomy Link Frequency
plasma 1
PAG 1
brain 1
uterine 1
T cells 1
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
depression 31 99.92 Very High Very High Very High
abdominal pain 1 99.32 Very High Very High Very High
Morphine 22 99.18 Very High Very High Very High
Dismenorea 4 98.96 Very High Very High Very High
Eae 7 98.68 Very High Very High Very High
tolerance 46 98.24 Very High Very High Very High
antinociception 4 98.22 Very High Very High Very High
Dopamine 635 97.20 Very High Very High Very High
Antinociceptive 4 89.76 High High
alcohol 49 88.52 High High
Disease Link Frequency Relevance Heat
Depression 31 99.92 Very High Very High Very High
Abdominal Pain 1 99.32 Very High Very High Very High
Targeted Disruption 99 99.04 Very High Very High Very High
Dysmenorrhea 4 98.96 Very High Very High Very High
Urological Neuroanatomy 7 98.94 Very High Very High Very High
Vomiting 2 98.56 Very High Very High Very High
Impaired Glucose Tolerance 40 98.12 Very High Very High Very High
Diarrhoea 1 97.84 Very High Very High Very High
Hypothermia 3 94.88 High High
Aging 6 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Observation from our study also depicted downregulation of PP2A (PP2AA in particular without change in PP2AB) following acute ethanol challenge, the effect of which was augmented by the ADH transgene.
Negative_regulation (downregulation) of PP2A
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.03
Observation from our study also depicted downregulation of PP2A (PP2AA in particular without change in PP2AB) following acute ethanol challenge, the effect of which was augmented by the ADH transgene.
Negative_regulation (downregulation) of PP2AA
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.03
Because a-Syn Ser-129 phosphorylation reduced the a-Syn effect on TH and PP2A, a shift in a-Syn levels along with changes in the levels of Ser(P)-129 could dysregulate a-Syn-modulated proteins, especially in aging brain (62).
Negative_regulation (reduced) of PP2A in brain associated with aging
3) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.30 Pain Relevance 0.03
ERK phosphorylation was diminished in a-Syn cells compared with GFP-transfected MN9D controls, and furthermore, inhibition of PP2A increased ERK phosphorylation in our cells (data not shown), suggesting that only a-Syn interacting proteins were affected by a-Syn-mediated PP2A activation.
Negative_regulation (inhibition) of PP2A
4) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
Okadaic acid (OA), which inhibits protein phosphatase-1 (PP1) and PP2A, has been shown to alter uterine contractions.
Negative_regulation (inhibits) of PP2A in uterine associated with dismenorea
5) Confidence 0.38 Published 2000 Journal Biol. Reprod. Section Abstract Doc Link 10952921 Disease Relevance 0.19 Pain Relevance 0.19
When reaction (i) and (iii) are set to zero, the reduction in PKAc–PP2A and PKAc–phosphoThr75 complexes are smaller than in the control case.
Negative_regulation (reduction) of PKAc-PP2A
6) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.18
Opening reaction (i) eliminates the reduction of PKAc-PP2A by calcium, and opening reaction (iii) eliminates the reduction of PKAc-phosphoThr75 by calcium.
Negative_regulation (reduction) of PKAc-PP2A
7) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14
This decrease in PKAc–PP2A (Figure S1B) shifts the equilibrium of reaction (i), thus PKAc dissociates from PP2A.
Negative_regulation (decrease) of PKAc-PP2A
8) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.10
This was supported by the fact that the same treatment with okadaic acid blocked the increase in phosphatase activity in PAG of morphine tolerant mice indicating that selective inhibition of PP2A contributes to enhanced levels of morphine tolerance.
Negative_regulation (inhibition) of PP2A in PAG associated with tolerance, urological neuroanatomy and morphine
9) Confidence 0.36 Published 2007 Journal Brain Res. Section Abstract Doc Link 17582387 Disease Relevance 0.24 Pain Relevance 1.37
Acute morphine antinociception has been shown to be blocked by very low picogram doses of okadaic acid indicating that inhibition of protein phosphatase PP2A allows for increases in phosphorylation to inhibit antinociception.
Negative_regulation (inhibition) of PP2A associated with antinociception and morphine
10) Confidence 0.36 Published 2007 Journal Brain Res. Section Abstract Doc Link 17582387 Disease Relevance 0.16 Pain Relevance 0.68
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Negative_regulation (downregulation) of PP2A
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.41 Pain Relevance 0.08
Ethanol exposure led to glucose intolerance, elevated plasma insulin, compromised cardiac contractile and intracellular Ca2+ properties, downregulated protein phosphatase PP2A subunit and PPAR-?
Negative_regulation (downregulated) of PP2A in plasma associated with impaired glucose tolerance
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.35 Pain Relevance 0.15
First, it reduces the amount of unbound PP2A, and thus reduces the substrate available for PKAc binding.
Negative_regulation (reduces) of PP2A
13) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.10
The relative changes in the reaction flows are dependent on the biochemical reactions involving PKAc (Figure S1 further illustrates the quantitative role that PP2A substrate depletion and phosphoThr75 inhibition of free PKAc play in the feedback loop).
Negative_regulation (inhibition) of PP2A
14) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.04
Increased tau phosphorylation in non-transgenic mice has also been shown to be associated with decreased protein phosphatase 2A (PP2A) activity [18], [19].
Negative_regulation (decreased) of PP2A associated with targeted disruption and eae
15) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.56 Pain Relevance 0.26
OA is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A), enzymes that are known to be critical regulators of embryonic development.
Negative_regulation (inhibitor) of PP2A
16) Confidence 0.26 Published 2010 Journal Toxicon Section Abstract Doc Link 20026154 Disease Relevance 0.39 Pain Relevance 0.10
In mice lacking calcineurin or with expression of small t antigen of simian virus 40 inhibiting PP2A, LTD is selectively reduced.
Negative_regulation (inhibiting) of PP2A associated with depression
17) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 1.27 Pain Relevance 0.48
Treatment of 2C T cells with PP2 and Wortmannin, inhibitors of protein tyrosine kinases (PTKs) and phosphoinositide 3-kinase (PI3-K), respectively, dramatically reduced the level of pMV-absorption, while treatment with Pervanadate, a protein tyrosine phosphatase inhibitor, significantly elevated the level of pMV-absorption.
Negative_regulation (inhibitors) of PP2 in T cells
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.03

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